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Abstract：
Background and objectives Obesity is a major global health concern linked with increased risk of chronic diseases. This study aimed to assess the levels of fibroblast growth factor 21 (FGF21) in subjects with obesity after gastric sleeve surgery and explore its correlation with lipid and glycemic parameters. Methods This retrospective cohort study included 28 obese male subjects aged 25 to 50 years, undergoing gastric sleeve surgery. Plasma levels of FGF21 were measured by enzyme-linked immunosorbent assay (ELISA) before and six to 12 months after surgery. Other parameters including body mass index (BMI), fasting glucose, lipid profile, and insulin were also assessed and homeostatic model assessment (HOMA) was used to estimate insulin resistance. Results There was a significant increase in systemic FGF21 levels after surgery (45.12 vs. 126.16 pg/mL, p = 0.007). There was also a notable reduction in BMI (51.55 vs. 39.14, p < 0.001), insulin levels (20.06 vs. 8.85 mIU/L, p < 0.001), HOMA scores (6.94 to 2.49, p < 0.001), and glucose levels (7.33 vs. 6.08, p = 0.039). Lipid profile analysis post-surgery showed an increase in total cholesterol (4.38 vs. 5.09 mmol/L, p < 0.001) and high-density lipoprotein (HDL) (0.88 vs. 1.52 mmol/L, p < 0.001), with a decrease in triglycerides (1.75 vs. 1.01 mmol/L, p = 0.007). FGF21 positively correlated with growth hormone (GH), p = 0.0015, r = 0.59, and with insulin like growth factor 1 (IGF-1), p = 0.03, r = 0.431. Conclusion FGF21 levels were increased following gastric sleeve surgery in obese male patients and were positively correlated with growth hormone and insulin IGF-1. These findings provide insights into the metabolic alterations following bariatric surgery and highlight the potential role of FGF21 as an important molecule in obesity management and treatment.
摘要：
背景和目的肥胖是与慢性疾病风险增加相关的主要全球健康问题。本研究旨在评估胃袖套手术后肥胖患者的成纤维细胞生长因子21（FGF21）水平，并探讨其与血脂和血糖参数的相关性。方法本回顾性队列研究包括28例25～50岁肥胖男性受试者,正在进行胃袖手术。术前及术后6～12个月采用酶联免疫吸附试验(ELISA)检测血浆FGF21水平。其他参数包括体重指数（BMI），空腹血糖,血脂谱,我们还评估了胰岛素,并使用稳态模型评估(HOMA)来评估胰岛素抵抗.结果术后全身FGF21水平显著升高（45.12vs.126.16pg/mL,p=0.007)。BMI也显着降低（51.55vs.39.14，p<0.001)，胰岛素水平（20.06vs.8.85mIU/L，p<0.001)，HOMA得分（6.94至2.49，p<0.001），和葡萄糖水平（7.33vs.6.08，p=0.039）。术后血脂分析显示总胆固醇升高（4.38vs.5.09mmol/L,p<0.001）和高密度脂蛋白（HDL）（0.88vs.1.52mmol/L,p<0.001)，随着甘油三酯的减少（1.75vs.1.01mmol/L,p=0.007)。FGF21与生长激素（GH）呈正相关，p=0.0015，r=0.59，与胰岛素样生长因子1（IGF-1），p=0.03,r=0.431。结论肥胖男性患者胃袖套术后FGF21水平升高,且与生长激素、胰岛素IGF-1呈正相关。这些发现为减肥手术后的代谢改变提供了见解，并强调了FGF21作为肥胖管理和治疗中重要分子的潜在作用。
