PDF(Pubmed)
Abstract：
Like the ovaries and prostate, the thyroid exhibits characteristic hormone secretion and regulation. Thyroid cancer (TC), especially differentiated thyroid carcinoma, has typical sex-specific and age-specific hormone-driven clinical features. Previous research has primarily focused on the effects of thyroid stimulating hormone, thyroid hormones, and estrogens on the onset and progression of TC, while the roles of growth hormone (GH), androgens, and glucocorticoids have largely been overlooked. Similarly, few studies have investigated the interactions between hormones and hormone systems. In fact, numerous studies of patients with acromegaly have shown that serum levels of GH and insulin-like growth factor-1 (IGF-1) may be associated with the onset and progression of TC, although the influences of age, sex, and other risk factors, such as obesity and stress, remain unclear. Sex hormones, the GH/IGF axis, and glucocorticoids are likely involved in the onset and progression of TC by regulating the tumor microenvironment and metabolism. The aim of this review was to clarify the roles of hormones and hormone systems in TC, especially papillary thyroid carcinoma, as references for further investigations.
摘要：
像卵巢和前列腺一样，甲状腺表现出特征性的激素分泌和调节。甲状腺癌(TC),尤其是分化型甲状腺癌,具有典型的性别特异性和年龄特异性激素驱动的临床特征。以前的研究主要集中在促甲状腺激素的作用上，甲状腺激素,和雌激素对TC的发病和进展，而生长激素（GH）的作用，雄激素,糖皮质激素在很大程度上被忽视了。同样，很少有研究调查激素和激素系统之间的相互作用。事实上,大量肢端肥大症患者的研究表明，血清GH和胰岛素样生长因子-1（IGF-1）水平可能与TC的发生和进展有关，虽然年龄的影响，性别,和其他风险因素，比如肥胖和压力，仍然不清楚。性激素,GH/IGF轴，糖皮质激素可能通过调节肿瘤微环境和代谢参与TC的发生和发展。这篇综述的目的是阐明激素和激素系统在TC中的作用。尤其是甲状腺乳头状癌,作为进一步调查的参考。
