月经停止(MC)后,脂质分布受到影响。我们旨在评估戈舍瑞林诱导的MC和随后的月经恢复(MR)对脂质代谢的影响。经组织学证实的子宫内膜异位症的绝经前妇女(n=15)每月接受戈舍瑞林治疗6个月(6mo),导致MC,并在MR(12mo)后再随访6个月。血清总胆固醇(TC),甘油三酯(TG),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C),载脂蛋白A1(ApoA1),载脂蛋白B(ApoB),脂蛋白a([Lp(a)]和脂质组学在基线测量,6mo和12mo。在脂质类别的水平上确定了猎枪定量的深层脂质组学,子类,物种,和脂肪酰基链长度和饱和度。TC(p=0.006),LDL-C(p=0.028),HDL-C(p=0.002),在戈舍瑞林诱导的MC期间,apoA1(p=0.013)增加,在MR期间几乎保持不变。TG,apoB,Lp(a)没有改变。从深层脂质组学分析,多变量统计分析表明,MC的脂质种类发生了深刻的变化,而没有统计有效的模型可以适用于恢复期。总之,GnRH类似物诱导的MC在不同水平改变血脂谱,从标准血脂和脂蛋白谱到脂质组学分析检测到的几种脂质。MR后变化至少持续6m。
The lipid profile is affected following menstrual cessation (MC). We aimed to evaluate the effects of goserelin-induced MC and subsequent menstrual restoration (MR) on lipid metabolism. Premenopausal women with histologically verified endometriosis (n = 15) received goserelin monthly for 6 months (6mο), resulting in MC, and were followed-up for another 6 months after MR (12mο). Serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), lipoprotein a ([Lp(a)] and lipidomics were measured at baseline, 6mo and 12mo. Shotgun quantitative deep lipidomics were determined at the level of lipid class category, subclass, species, and fatty acyl chain lengths and degree of saturation. TC (p = 0.006), LDL-C (p = 0.028), HDL-C (p = 0.002), and apoA1 (p = 0.013) increased during goserelin-induced MC and remained practically unchanged during MR. TG, apoB, and Lp(a) did not change. From the deep lipidomics analysis, multivariate statistical analysis demonstrated profound alterations in lipid species with MC, whereas no statistically valid models could be fitted for the restoration period. In conclusion, GnRH-analog-induced MC alters lipid profiles at various levels, from standard blood lipid and lipoprotein profiles to several lipid species as detected by lipidomics analysis. Changes largely persist for at least 6 m after MR.