■为了研究开放性脊髓发育不良(OSD)胎儿队列中透明隔(SP)异常的患病率,并确定这种情况是否继发于阻塞性脑室肥大,因此,产前颅内低血压(PICH)综合征自然史的一部分。
■分析了OSD胎儿的磁共振成像(MRI)研究。使用胎儿大脑的轴向和冠状T2加权图像评估SP,并将其分类为完整,部分缺席,或者完全缺席。此外,SP的存在或不存在与侧脑室大小之间的相关性,小脑扁桃体突出程度,第四脑室的塌陷,并对椎间角进行了研究。
■共研究了32例OSD胎儿。胎儿MRI时的平均胎龄为25.5±3.9周(范围,19-35),平均心室大小为16.2±4.2mm(范围,8-26).23例(71.9%)胎儿患有小脑扁桃体疝。IPA完全崩溃23例(71.9%),减少了七个(21.9%),和不可读的两个(6.3%)。20例(62.5%)胎儿出现完整的SP,10(31.3%)部分无SP(不完全开窗),和两个(6.3%)完全没有SP(完全开窗)。SP的开窗与心室肥大程度显着相关(Pearson的相关系数=0.459;p=.01)。然而,与IPA没有相关性,第四脑室的塌陷,小脑扁桃体疝.
■超过三分之一的OSD胎儿有SP开窗。最可能的病因是脑室内压力增加,导致SP局部坏死。由于SP的开窗是与PICH综合征相关的次要事件,这种情况不应被视为宫内修复脊柱缺损的禁忌症。相反,应将其视为脑室内压严重程度的指标.
UNASSIGNED: To study the prevalence of abnormalities of the septi pellucidi (SP) in a cohort of fetuses with open spinal dysraphism (OSD) and to determine whether this condition is secondary to obstructive ventriculomegaly and, therefore, part of the natural history of prenatal intracranial hypotension (PICH) syndrome.
UNASSIGNED: Magnetic resonance imaging (MRI) studies from fetuses with OSD were analyzed. The SP were assessed using axial and coronal T2-weighted images of the fetal brain and classified as intact, partially absent, or completely absent. Additionally, the correlation between the presence or absence of the SP and the size of the lateral ventricles, degree of cerebellar tonsillar herniation, collapse of the fourth ventricle, and interpeduncular angle was investigated.
UNASSIGNED: A total of 32 fetuses with OSD were studied. Mean gestational age at the time of the fetal MRI was 25.5 ± 3.9 weeks (range, 19-35) and mean ventricular size was 16.2 ± 4.2 mm (range, 8-26). Twenty-three (71.9%) fetuses had cerebellar tonsillar herniation. The IPA was completely collapsed in 23 cases (71.9%), reduced in seven (21.9%), and unreadable in two (6.3%). Twenty (62.5%) fetuses presented with intact SP, 10 (31.3%) with partially absent SP (incomplete fenestration), and two (6.3%) with completely absent SP (complete fenestration). Fenestration of the SP correlated significantly with the degree of ventriculomegaly (Pearson\'s correlation coefficient =0.459; p = .01). However, there was no correlation with the IPA, collapse of the fourth ventricle, and cerebellar tonsillar herniation.
UNASSIGNED: More than one-third of the fetuses with OSD had fenestration of the SP. The most probable etiology is increased intraventricular pressure leading to local necrosis of the SP. As fenestration of the SP is a secondary event associated with PICH syndrome, this condition should not be considered a contraindication for intrauterine repair of the spinal defect. Instead, it should be seen as an indicator of the severity of the intraventricular pressure.