背景:在患有心脏疾病的猫中已经证实了高凝状态。然而,止血参数,在患有动脉血栓栓塞症(ATE)的猫中,尚未报道包括粘弹性凝血监测(VCM)。
目的:比较急性心源性ATE猫和对照猫的VCM参数。
方法:16只带有ATE的猫和30只对照猫。
方法:基于多中心大学的前瞻性研究。心源性ATE是根据体格检查和超声诊断的左心房扩大诊断的。粘弹性凝血监测分析,CBC,在患有ATE的猫入院时进行血清生化谱和凝血谱。使用通过直接静脉穿刺收集的血液进行来自健康对照猫的分析。我们的目的是比较VCM参数凝块时间(CT),凝块形成时间(CFT),α角(Angle),最大凝块形成(MCF),ATE和对照猫之间在10和20分钟时的振幅(分别为A10和A20)和在30和45分钟时的凝块溶解指数(分别为LI30和LI45)。
结果:与对照猫相比,患有ATE的猫的角度减小,中位数(范围)为43°(30-48°),而47°(14-59°;P=.01)。与对照猫相比,ATE猫的参数A10,A20和MCF降低,中位数(范围)为19个单位(8-32),而22个单位(6-38)。24.5个单位(11-40)与29个单位(10-47)相比,29.5个单位(13-44)与33.5个单位(14-53)相比,分别(P=.01、.01和.01)。参数CT,CFT,LI30和LI45组间相似(P分别为.22、.09、.62和.34)。
结论:与健康猫相比,患有心源性ATE猫的VCM参数与低凝性一致。
BACKGROUND: Hypercoagulability has been documented in cats with cardiac disease. However, hemostatic parameters, including viscoelastic coagulation monitoring (VCM) have not been reported in cats with arterial thromboembolism (ATE).
OBJECTIVE: Compare VCM parameters in cats with acute cardiogenic ATE and in control cats.
METHODS: Sixteen cats with ATE and 30 control cats.
METHODS: Multicenter university-based prospective study. Cardiogenic ATE was diagnosed based on physical examination and by ultrasonographically-diagnosed left atrial enlargement. Viscoelastic coagulation monitor analysis, CBC, serum biochemistry profile and coagulation profile were performed at admission in cats with ATE. Analysis from healthy control cats was performed using blood collected by direct venipuncture. Our objective was comparison of VCM parameters clot time (CT), clot formation time (CFT), alpha angle (Angle), maximum clot formation (MCF), amplitude at 10 and 20 minutes (A10 and A20, respectively) and clot lysis index at 30 and 45 minutes (LI30 and LI45, respectively) between ATE and control cats.
RESULTS: Cats with ATE had a decreased angle compared to control cats, with a median (range) of 43° (30-48°) compared to 47° (14-59°; P = .01). The parameters A10, A20 and MCF were decreased in ATE cats compared to control cats with a median (range) of 19 units (8-32) compared to 22 units (6-38), 24.5 units (11-40) compared to 29 units (10-47) and 29.5 units (13-44) compared to 33.5 units (14-53), respectively (P = .01, .01 and .01, respectively). The parameters CT, CFT, LI30 and LI45 were similar between groups (P = .22, .09, .62 and .34, respectively).
CONCLUSIONS: Cats with cardiogenic ATE cats have VCM parameters consistent with hypocoagulability compared with healthy cats.