PDF(Pubmed)
Abstract：
UNASSIGNED: Elevated ambient pollution exposure is potentially linked to thromboembolism. However, the mechanisms by which particulate matter (PM) interferes with the balance of hemostatic system remain unclear. This study investigates PM-mediated hemostatic changes in individuals across unique seasonal variations of ambient pollution.
UNASSIGNED: This prospective study was conducted between February and July 2020 during alterations in ambient pollution in Chiang Mai, Thailand. Blood tests from 30 healthy subjects were assessed at four-week intervals, four times in total. Various coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (aPTT), von Willebrand factor (vWF), platelet count, and platelet functions, were evaluated. A mixed-effects model was used to analyze the impact of high PM2.5 and PM10 on hemostatic parameters.
UNASSIGNED: Thirty male subjects with mean age of 38.9 ± 8.2 years, were included. High levels of PM2.5 and PM10 were significantly associated with PT shortening, with no such effect observed in aPTT. PM2.5 and PM10 values also positively correlated with vWF function, while vWF antigen levels remained unchanged. Soluble P-selectin showed a strong positive association with PM2.5 and PM10 levels. Platelet function analysis revealed no correlation with PM values.
UNASSIGNED: Short-term exposure to elevated PM2.5 and PM10 concentrations was linked to shortened PT and enhanced vWF function in healthy individuals. Exploring the impact of these changes on clinically relevant thrombosis is crucial. Additional studies on the pathogenesis of pollution-related thrombosis are warranted for maintaining good health.
UNASSIGNED: This prospective study was conducted between February and July 2020 during alterations in ambient pollution in Chiang Mai, Thailand. Blood tests from 30 healthy subjects were assessed at four-week intervals, four times in total. Various coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (aPTT), von Willebrand factor (vWF), platelet count, and platelet functions, were evaluated. A mixed-effects model was used to analyze the impact of high PM2.5 and PM10 on hemostatic parameters.
UNASSIGNED: Thirty male subjects with mean age of 38.9 ± 8.2 years, were included. High levels of PM2.5 and PM10 were significantly associated with PT shortening, with no such effect observed in aPTT. PM2.5 and PM10 values also positively correlated with vWF function, while vWF antigen levels remained unchanged. Soluble P-selectin showed a strong positive association with PM2.5 and PM10 levels. Platelet function analysis revealed no correlation with PM values.
UNASSIGNED: Short-term exposure to elevated PM2.5 and PM10 concentrations was linked to shortened PT and enhanced vWF function in healthy individuals. Exploring the impact of these changes on clinically relevant thrombosis is crucial. Additional studies on the pathogenesis of pollution-related thrombosis are warranted for maintaining good health.
摘要：
■增加的环境污染暴露可能与血栓栓塞有关。然而,颗粒物（PM）干扰止血系统平衡的机制尚不清楚。这项研究调查了在环境污染的独特季节变化中，PM介导的个体止血变化。
■这项前瞻性研究是在2020年2月至7月期间在清迈的环境污染变化期间进行的，泰国。每隔四周对30名健康受试者的血液检查进行评估，总共四次。各种凝血试验,包括凝血酶原时间（PT），活化部分凝血活酶时间（aPTT），血管性血友病因子(vWF)，血小板计数,和血小板功能，进行了评估。采用混合效应模型分析高PM2.5和PM10对止血参数的影响。
■30名男性受试者，平均年龄38.9±8.2岁，包括在内。高水平的PM2.5和PM10与PT缩短显著相关，在aPTT中没有观察到这种效果。PM2.5和PM10值也与vWF函数呈正相关，而vWF抗原水平保持不变。可溶性P-选择素与PM2.5和PM10水平呈显著正相关。血小板功能分析显示与PM值无相关性。
■短期暴露于升高的PM2.5和PM10浓度与健康个体的PT缩短和vWF功能增强有关。探索这些变化对临床相关血栓形成的影响至关重要。需要对与污染相关的血栓形成的发病机理进行更多研究，以保持良好的健康状态。
■这项前瞻性研究是在2020年2月至7月期间在清迈的环境污染变化期间进行的，泰国。每隔四周对30名健康受试者的血液检查进行评估，总共四次。各种凝血试验,包括凝血酶原时间（PT），活化部分凝血活酶时间（aPTT），血管性血友病因子(vWF)，血小板计数,和血小板功能，进行了评估。采用混合效应模型分析高PM2.5和PM10对止血参数的影响。
■30名男性受试者，平均年龄38.9±8.2岁，包括在内。高水平的PM2.5和PM10与PT缩短显著相关，在aPTT中没有观察到这种效果。PM2.5和PM10值也与vWF函数呈正相关，而vWF抗原水平保持不变。可溶性P-选择素与PM2.5和PM10水平呈显著正相关。血小板功能分析显示与PM值无相关性。
■短期暴露于升高的PM2.5和PM10浓度与健康个体的PT缩短和vWF功能增强有关。探索这些变化对临床相关血栓形成的影响至关重要。需要对与污染相关的血栓形成的发病机理进行更多研究，以保持良好的健康状态。
