■在过去的十年中,胆道系统疾病的发病率一直在不断增加。胆道系统疾病给人类和社会带来了沉重的负担。然而,具体病因和发病机制尚不清楚。胆道系统,作为肝脏和肠道之间的桥梁,在维持机体的生理代谢中起着不可或缺的作用。因此,胆道疾病的预防和治疗至关重要。值得注意的是,微生物参与胆管的脂质代谢,尤其是肠道细菌所占比例最大。
■我们系统回顾了胆结石(GS)患者的肠道菌群,非结石性胆道炎症,和胆道癌(BTC)。搜索了Pubmed,Embase和Webofscience的研究报告发表于2023年11月。
■我们发现GS中粪杆菌属的丰度降低,原发性硬化性胆管炎(PSC),原发性胆汁性胆管炎(PBC)和BTC。Veillonella,乳酸菌,链球菌和肠球菌属在PSC中显著增加,PBC和BTC。有趣的是,我们发现梭菌的相对丰度在GS中普遍降低,PBC和BTC。然而,梭菌在PSC中通常增加。
■现有研究大多集中在探索细菌靶向单一疾病的机制上。缺乏多种疾病和疾病过程中细菌变化的比较。我们希望为胆道系统疾病的早期诊断提供生物标志物,并为肠道菌群在胆道疾病中的作用机制提供新的方向。
UNASSIGNED: The incidence of biliary system diseases has been continuously increasing in the past decade. Biliary system diseases bring a heavy burden to humanity and society. However, the specific etiology and pathogenesis are still unknown. The biliary system, as a bridge between the liver and intestine, plays an indispensable role in maintaining the physiological metabolism of the body. Therefore, prevention and treatment of biliary diseases are crucial. It is worth noting that the microorganisms participate in the lipid metabolism of the bile duct, especially the largest proportion of intestinal bacteria.
UNASSIGNED: We systematically reviewed the intestinal microbiota in patients with gallstones (GS), non-calculous biliary inflammatory, and biliary tract cancer (BTC). And searched Pubmed, Embase and Web of science for research studies published up to November 2023.
UNASSIGNED: We found that the abundance of Faecalibacterium genus is decreased in GS, primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC) and BTC. Veillonella, Lactobacillus, Streptococcus and Enterococcus genus were significantly increased in PSC, PBC and BTC. Interestingly, we found that the relative abundance of Clostridium was generally reduced in GS, PBC and BTC. However, Clostridium was generally increased in PSC.
UNASSIGNED: The existing research mostly focuses on exploring the mechanisms of bacteria targeting a single disease. Lacking comparison of multiple diseases and changes in bacteria during the disease process. We hope to provide biomarkers forearly diagnosis of biliary system diseases and provide new directions for the mechanism of intestinal microbiota in biliary diseases.