空气污染物与肝胆胰腺疾病之间的关系仍然没有定论。这项研究分析了来自英国生物银行的多达247,091名白人欧洲血统的参与者(招募时年龄在37至73岁之间),开放获取的大规模前瞻性队列。空气污染评分用于评估PM2.5,PM2.5-10,PM10,NO2和NOX对总肝胆胰腺疾病的综合影响。肝脏疾病,胆囊疾病,和胰腺疾病。采用Cox比例风险模型来评估空气污染物与这些疾病发生率之间的关系。限制性三次样条回归用于检查空气污染物与肝胆胰腺疾病风险之间的剂量反应关系。我们确定了4865例全肝胆胰疾病,中位随访时间为10.86年。空气污染评分与肝脏疾病风险增加中度相关(HR=1.009,95%CI:1.004,1.014),但不是胆囊和胰腺疾病。在单个空气污染物中,PM2.5(HR=1.069,95%CI:1.025,1.115)和PM10(HR=1.036,95%CI:1.011,1.061)显著增长肝病风险。男性发现PM2.5有较高的肝病风险(HR=1.075,95%CI:1.015,1.139)。此外,超重个体(HR=1.125,95%CI:1.052,1.203),年龄≥60且≤73(HR=1.098,95%CI:1.028,1.172),酒精摄入量≥14单位/周(HR=1.078,95%CI:1.006,1.155)在高度暴露于PM2.5时发生肝病的风险更高。这项研究表明,长时间暴露于环境空气污染物可能会增加肝脏疾病的风险。
The association between air pollutants and hepatobiliary pancreatic diseases remains inconclusive. This study analyzed up to 247,091 participants of White European ancestry (aged 37 to 73 years at recruitment) from the UK Biobank, a large-scale prospective cohort with open access. An air pollution score was utilized to assess the combined effect of PM2.5, PM2.5-10, PM10, NO2, and NOX on total hepatobiliary pancreatic diseases, liver diseases, cholecyst diseases, and pancreatic diseases. Cox proportional hazard models were employed to evaluate the relationships between air pollutants and the incidence of these diseases. Restricted cubic spline regressions were used to examine the dose-response association between air pollutants and the risk of hepatobiliary pancreatic diseases. We identified 4865 cases of total hepatobiliary pancreatic diseases, over a median follow-up of 10.86 years. The air pollution scores were moderately associated with increased liver disease risk (HR = 1.009, 95 % CI: 1.004, 1.014), but not with cholecyst and pancreatic diseases. Among the individual air pollutants, PM2.5 (HR = 1.069, 95 % CI: 1.025, 1.115) and PM10 (HR = 1.036, 95 % CI: 1.011, 1.061) significantly increased liver disease risk. Males showed a higher risk of liver diseases with PM2.5 (HR = 1.075, 95 % CI: 1.015, 1.139). Additionally, individuals with overweight (HR = 1.125, 95 % CI: 1.052, 1.203), age ≥ 60 and ≤73 (HR = 1.098, 95 % CI: 1.028, 1.172), and alcohol intake ≥ 14 unit/week (HR = 1.078, 95 % CI: 1.006, 1.155) had a higher risk of developing liver diseases at high expose to PM2.5. This study suggests that prolonged exposure to ambient air pollutants may elevate the risk of liver diseases.