种植牙修复是修复缺牙的有效方法。慢性牙周炎患者牙周种植失败率与牙周菌群有关,炎症,慢性牙周炎引起的长期牙周骨吸收。然而,种植牙修复对慢性牙周炎患者炎症的治疗作用尚未得到解决。这项研究的目的是评估炎症的风险指标,慢性牙周炎患者的骨丢失和种植失败。共纳入284例种植牙修复患者,分为牙周健康患者(n=128)和慢性牙周炎患者(n=156)。牙周指数包括探测深度(PD),沟出血指数(SBI),菌斑指数(PLI),比较两组牙龈出血(GIL)和探查出血(BOP)。炎性细胞因子包括肿瘤坏死因子-α(TNF-α),白细胞介素-6(IL-6),白细胞介素-1(IL-1),基线时的基质金属蛋白酶-2(MMP-2)和基质金属蛋白酶-9(MMP-9)水平,手术后6个月和12个月,手术后12个月的植入物存活率,以及与牙种植体失败相关的危险因素也被评估。结果表明,慢性牙周炎组患者的牙周指数高于牙周健康组。慢性牙周炎组的所有炎症参数均高于牙周健康组,并且与慢性牙周炎患者的慢性牙周指数(CPI)呈负相关。慢性牙周炎患者的黏膜炎和种植体周围炎的患病率高于健康牙周炎患者。植入物直径,对于接受牙种植的慢性牙周炎患者,长度和设计与种植失败的风险相关.慢性牙周炎患者术后12个月的累积种植失败率和种植骨折发生率分别为12.10%和7.23%(p<0.05),分别,而在健康性牙周炎患者中则较低。位置,直径,种植体设计,即刻负荷和骨缺损是种植牙患者骨丢失的风险指标。慢性牙周炎患者种植牙失败的危险因素高于牙周健康组(14.25%vs.4.92%,p<0.05)。总之,当前研究中的数据表明炎症是骨丢失的风险指标,慢性牙周炎患者的种植体骨折和种植体失败。
Dental implant restoration shows an effective method for the rehabilitation of missing teeth. The failure rate of periodontal implants in patients with chronic periodontitis is associated with periodontal flora, inflammation, and long-term periodontal bone resorption caused by chronic periodontitis. However, the therapeutic effects of dental implant restoration on inflammation in patients with chronic periodontitis have not addressed. The purpose of this study is to evaluate the risk indicators for inflammation, bone loss and implant failure in patients with chronic periodontitis. A total of 284 patients with dental implant restoration were recruited and divided into periodontally healthy patients (n = 128) and chronic periodontitis patients (n = 156). Periodontal indices including probing depth (PD), sulcus bleeding index (SBI), plaque index (PLI), gingival bleeding (GIL) and bleeding on probing (BOP) were compared in two groups. Inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1 (IL-1), matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) levels at baseline, 6 and 12 months after surgery, and the implant survival rate at 12 months after surgery, as well as the risk factors associated with failure of dental implant were also assessed. Outcomes demonstrated that patients in the chronic periodontitis group had higher values of periodontal indices than those in the periodontally healthy group. All inflammatory parameters in the chronic periodontitis group were higher than those in the periodontally healthy group and negatively associated with the chronic periodontal index (CPI) in chronic periodontitis patients. Chronic periodontitis patients had higher the prevalence of mucositis and peri-implantitis than patients with healthy periodontium. Implant diameter, length and design was associated with the risk of implant failure for chronic periodontitis patients receiving dental implant. The cumulative implant failure rate and incidence of implant fractures for chronic periodontitis patients at 12 months after surgery were 12.10% and 7.23% (p < 0.05), respectively, while were lower in the heathy periodontitis patients. Location, diameter, implant design, immediate loading and bone defect were risk indicators for bone loss for dental implant patients. The risk factors associated with failure of dental implant was higher in chronic periodontitis patients than patients in the periodontally healthy group (14.25% vs. 4.92%, p < 0.05). In conclusion, data in the current study indicate that inflammation is a risk indicator bone loss, implant fracture and implant failure in patients with chronic periodontitis.