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Abstract：
OBJECTIVE: This study aims to compare the clinical and radiographic outcomes after complete versus incomplete removal of granulation tissue (GT) during modified minimally invasive surgical technique (M-MIST) for management of periodontitis patients with deep pockets associated with infra-bony defects.
METHODS: Ten patients with a total of 14 deep non-resolving pockets (≥ 5 mm) associated with a vertical infra-bony defect were recruited for this study. They were randomized into 2 groups; a test group with incomplete removal of GT and a control group with complete removal of GT. Clinical parameters of clinical attachment level (CAL), residual probing depth (rPD) and buccal recession (Rec.) were recorded every 3 months. Radiographic periapicals were taken at baseline, 6 and 9 months. The significance level was set to 0.05.
RESULTS: None of the results showed statistical significance between the 2 groups (p > 0.05). The test group showed less CAL gain (2 ± 0.87 mm, p = 0.062), more reduction in rPD (3.1 ± 0.96 mm, p = 0.017) and more recession (0.857 ± 0.26 mm, p = 0.017) than control group CAL gain (2.4 ± 0.58 mm, p = 0.009), rPD reduction (2.9 ± 0.3 mm, p = 0.001) and recession (0.5 ± 0.34 mm, p = 0.203) respectively. Control group had linear reduction in depth defect (DD) (0.68 ± 0.287, p = 0.064) compared to an increase in DD in test group (-0.59 ± 0.5, p = 0.914).
CONCLUSIONS: No statistical significance were observed in healing parameters between complete removal of GT in M-MIST and incomplete (partial) removal of GT of deep pockets with infra-bony defects both clinically and radiographically. Further studies with larger samples are needed to confirm the results.
METHODS: Ten patients with a total of 14 deep non-resolving pockets (≥ 5 mm) associated with a vertical infra-bony defect were recruited for this study. They were randomized into 2 groups; a test group with incomplete removal of GT and a control group with complete removal of GT. Clinical parameters of clinical attachment level (CAL), residual probing depth (rPD) and buccal recession (Rec.) were recorded every 3 months. Radiographic periapicals were taken at baseline, 6 and 9 months. The significance level was set to 0.05.
RESULTS: None of the results showed statistical significance between the 2 groups (p > 0.05). The test group showed less CAL gain (2 ± 0.87 mm, p = 0.062), more reduction in rPD (3.1 ± 0.96 mm, p = 0.017) and more recession (0.857 ± 0.26 mm, p = 0.017) than control group CAL gain (2.4 ± 0.58 mm, p = 0.009), rPD reduction (2.9 ± 0.3 mm, p = 0.001) and recession (0.5 ± 0.34 mm, p = 0.203) respectively. Control group had linear reduction in depth defect (DD) (0.68 ± 0.287, p = 0.064) compared to an increase in DD in test group (-0.59 ± 0.5, p = 0.914).
CONCLUSIONS: No statistical significance were observed in healing parameters between complete removal of GT in M-MIST and incomplete (partial) removal of GT of deep pockets with infra-bony defects both clinically and radiographically. Further studies with larger samples are needed to confirm the results.
摘要：
目的：本研究旨在比较改良的微创外科技术（M-MIST）治疗牙周炎患者的骨下缺损时，肉芽组织（GT）完全和不完全切除后的临床和影像学结果。
方法：本研究招募了10名患者，这些患者共有14个与垂直骨下缺损相关的深度非分辨口袋（≥5mm）。他们被随机分为2组；测试组完全去除GT，对照组完全去除GT。临床依恋水平（CAL）的临床参数，残余探测深度(rPD)和颊部衰退(Rec.)每3个月记录一次。在基线时进行放射照相，6和9个月。显著性水平设定为0.05。
结果：两组间无统计学意义（p>0.05）。实验组显示较少的CAL增益（2±0.87mm，p=0.062),rPD减少更多(3.1±0.96毫米，p=0.017)和更多的衰退(0.857±0.26毫米，p=0.017）比对照组CAL增益（2.4±0.58mm，p=0.009),rPD减少(2.9±0.3mm,p=0.001)和衰退(0.5±0.34毫米，p=0.203)。与测试组的DD增加（-0.59±0.5，p=0.914）相比，对照组的深度缺陷（DD）线性减少（0.68±0.287，p=0.064）。
结论：在临床和影像学上，在M-MIST中完全去除GT和不完全（部分）去除具有骨下缺损的深口袋GT之间的愈合参数没有观察到统计学意义。需要对更大样本进行进一步研究以确认结果。
方法：本研究招募了10名患者，这些患者共有14个与垂直骨下缺损相关的深度非分辨口袋（≥5mm）。他们被随机分为2组；测试组完全去除GT，对照组完全去除GT。临床依恋水平（CAL）的临床参数，残余探测深度(rPD)和颊部衰退(Rec.)每3个月记录一次。在基线时进行放射照相，6和9个月。显著性水平设定为0.05。
结果：两组间无统计学意义（p>0.05）。实验组显示较少的CAL增益（2±0.87mm，p=0.062),rPD减少更多(3.1±0.96毫米，p=0.017)和更多的衰退(0.857±0.26毫米，p=0.017）比对照组CAL增益（2.4±0.58mm，p=0.009),rPD减少(2.9±0.3mm,p=0.001)和衰退(0.5±0.34毫米，p=0.203)。与测试组的DD增加（-0.59±0.5，p=0.914）相比，对照组的深度缺陷（DD）线性减少（0.68±0.287，p=0.064）。
结论：在临床和影像学上，在M-MIST中完全去除GT和不完全（部分）去除具有骨下缺损的深口袋GT之间的愈合参数没有观察到统计学意义。需要对更大样本进行进一步研究以确认结果。
