布鲁氏菌病的流行病学和临床分析对于公共卫生领导者加强疾病监测和病例管理策略至关重要。
■在这项研究中,我们旨在分析1,590例人类布鲁氏菌病的流行病学和临床特征。
■约72.08%(1,146)的患者为男性,27.92%(444)的患者为女性。至少88.18%(1,402/1,590)的患者有与绵羊/山羊和牛接触的历史,被确定为感染的主要危险因素。受影响最常见的年龄组是30-69岁,占所有病例的83.90%,平均年龄为47.3岁。同时,75.03%(1,193/1,590)的患者是农民,其次是工人(10.50%,167/1,590)。临床表现的范围各不相同,主要症状为疲劳(42.96%),关节痛(37.30%),和发烧(23.33%)。989名患者被诊断为关节炎,469例患者诊断为脊柱炎,至少53.96%(858/1,590)的患者出现外生殖器并发症。此外,约41.25%(625/1,515)和24.53%(390/1,590)的病例显示CRP和D-二聚体水平升高,分别。相反,纤维蛋白原显著下降,总蛋白质,和白蛋白水平,影响48.36%(769/1,590),77.30%(1,226/1,586),和91.80%(1,456/1,586)的患者,分别。这些数据表明,布鲁氏菌病是一种严重的消耗性疾病,导致营养代谢失衡和免疫力下降。总的来说,86.73%(1,379/1,590)的患者使用抗生素治疗后表现出改善,而13.27%(211/1,590)的患者经历了复发或治疗失败。
布鲁氏菌病通常表现为非特异性症状和实验室检查结果,伴随着多器官入侵,也是诊断和治疗的重要挑战;因此,必须高度怀疑布鲁氏菌病,以便及时诊断和治疗。本研究为制定针对性的对策以遏制其进一步传播提供了基础数据和资源。
UNASSIGNED: Epidemiological and clinical analyses of brucellosis are vital for public health leaders to reinforce disease surveillance and case management strategies.
UNASSIGNED: In this study, we aimed to analyse the epidemiology and clinical features of 1,590 cases of human brucellosis.
UNASSIGNED: Approximately 72.08% (1,146) of the patients were male and 27.92% (444) were female. At least 88.18% (1,402/1,590) of the patients had a history of contact with sheep/goats and cattle, which was identified as the main risk factor for infection. The most common age group affected was 30-69 years, comprising 83.90% of all cases, with a median age of 47.3 years. Meanwhile, 75.03% (1,193/1,590) of the patients were farmers, followed by workers (10.50%, 167/1,590). The spectrum of clinical manifestations varied, and the major symptoms were fatigue (42.96%), joint pain (37.30%), and fever (23.33%). Arthritis was diagnosed in 989 patients, spondylitis was diagnosed in 469 patients, and external genital complications were found in at least 53.96% (858/1,590) of patients. In addition, approximately 41.25% (625/1,515) and 24.53% (390/1,590) of cases exhibited elevated CRP and D-dimer levels, respectively. Conversely, a significant decrease was observed in fibrinogen, total protein, and albumin levels, affecting 48.36% (769/1,590), 77.30% (1,226/1,586), and 91.80% (1,456/1,586) of the patients, respectively. These data demonstrate that brucellosis is a severe wasting disease that leads to an imbalance in nutritional metabolism and a decline in immunity. In total, 86.73% (1,379/1,590) of patients showed improvement with antibiotic therapy, while 13.27% (211/1,590) of patients experienced relapses or treatment failure.
UNASSIGNED: Brucellosis often presents with non-specific symptoms and laboratory findings, accompanied by multiple organ invasions, as well as being a vital challenge for diagnosis and treatment; thus, it is essential for a high degree of suspicion to be placed on brucellosis for a timely diagnosis and treatment. This study provides basic data and resources for developing tailored countermeasures to curb its further spread.