背景:轻度认知障碍(MCI)是由于生理老化引起的认知下降与神经退行性疾病如阿尔茨海默病(AD)中出现的严重程度下降之间的阶段,这是以认知障碍为特征的最常见的神经退行性疾病之一。MCI患者患AD的风险增加。虽然MCI和AD是无法治愈的,营养干预可能会延迟或阻止其发病。因此,用于减缓或缓解老年人认知障碍进展的有效干预措施是老年护理的重要焦点.鉴于营养对健康的协同作用,评估营养补充剂或膳食组合物在预防MCI或AD方面的有效性对于制定干预策略至关重要.
目的:我们的研究旨在评估各种营养干预措施的有效性,包括特殊的饮食类型,饮食模式,特定的食物,营养摄入,和营养补充剂,在预防诊断为MCI或AD的患者中认知功能下降。为了实现这一点,我们将采用全面的方法,包括网络荟萃分析,成对荟萃分析,和随机对照试验(RCTs)的系统评价。
方法:审查将遵循人口,干预,比较,结果(PICO)模型和PRISMA-P(系统评价和荟萃分析方案的首选报告项目)指南。两名调查人员将以电子方式独立搜索PubMed。数据提取将遵循纳入标准,数据将使用修订后的工具评估偏倚风险。此外,将使用建议分级来评估证据质量,评估,发展和评价(等级)框架。感兴趣的结果是评估MCI或AD患者的认知结果。将进行系统的文献检索,研究这些营养干预对MCI和AD患者认知功能下降的影响的随机对照试验。然后,网络荟萃分析(随机效应模型)和成对荟萃分析将估计不同营养干预措施的相对有效性。
结果:我们纳入了51项研究,发表于1999年至2023年(27项AD研究和24项MCI研究),涉及8420名参与者。到2023年12月,我们完成了所有51项研究的数据提取。目前,我们积极参与数据分析和稿件准备工作。我们计划在2024年底完成手稿并公布综合结果。
结论:考虑到MCI和AD患者的AD患病率上升以及营养干预对认知功能的潜在影响,我们的研究具有显著的临床意义。通过调查这种关系,我们的研究旨在为MCI和AD预防策略的制定提供循证决策.预计这些结果将有助于为MCI或AD管理建立可靠的建议,在该领域提供实质性支持。
背景:PROSPEROCRD4202231173;http://tinyurl.com/3snjp7a4。
■PRR1-10.2196/47196。
BACKGROUND: Mild cognitive impairment (MCI) is the stage between cognitive decline due to physiological aging and the severity of decline seen in neurodegenerative disorders like Alzheimer disease (AD), which is among the most prevalent neurodegenerative disorders characterized by cognitive impairment. People with MCI are at increased risk of developing AD. Although MCI and AD are incurable, nutritional interventions can potentially delay or prevent their onset. Consequently, effective interventions used to decelerate or alleviate the progress of cognitive impairment in older people are a significant focus in geriatric care. Given the synergistic effects of nutrition on health, assessing the effectiveness of nutritional supplements or dietary composition in preventing MCI or AD is essential for developing interventional strategies.
OBJECTIVE: Our study aims to assess the effectiveness of various nutritional interventions, including special dietary types, dietary patterns, specific foods, nutritional intake, and nutritional supplements, in preventing cognitive decline among patients diagnosed with MCI or AD. To achieve this, we will use a comprehensive approach, including network meta-analysis, pairwise meta-analysis, and systematic review of randomized controlled trials (RCTs).
METHODS: The review will follow the Population, Intervention, Comparison, Outcome (PICO) model and the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) guidelines. Two investigators will independently search PubMed electronically. Data extraction will follow the inclusion criteria, and data will be assessed for risk of bias using a revised tool. Additionally, evidence quality will be evaluated using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework. The outcomes of interest are assessing the cognitive outcomes in patients with MCI or AD. A systematic literature search will be conducted, identifying randomized controlled trials that investigate the impact of these nutritional interventions on cognitive function decline in individuals with MCI and AD. Network meta-analyses (random-effects model) and pairwise meta-analyses will then estimate the relative effectiveness of different nutritional interventions.
RESULTS: We included 51 studies, published between 1999 and 2023 (27 studies for AD and 24 studies for MCI) and involving 8420 participants. We completed data extraction for all 51 studies by December 2023. Currently, we are actively engaged in data analysis and manuscript preparation. We plan to finalize the manuscript and publish the comprehensive results by the end of 2024.
CONCLUSIONS: Our study holds significant clinical relevance given the rising prevalence of AD and the potential influence of nutritional interventions on cognitive function in individuals with MCI and AD. By investigating this relationship, our research aims to inform evidence-based decision-making in the development of prevention strategies for MCI and AD. The outcomes are expected to contribute to the establishment of reliable recommendations for MCI or AD management, providing substantial support in the field.
BACKGROUND: PROSPERO CRD42022331173; http://tinyurl.com/3snjp7a4.
UNASSIGNED: PRR1-10.2196/47196.