是否可以刺激涉及笑声的大规模大脑网络来补救情感症状的想法的实用性，即抑郁症,仍然难以捉摸。
在这项研究中,在静息状态下通过21通道定量脑电图（qEEG）设置对25名健康个体进行了测试，并提交了标准化的有趣视频剪辑（由两名行为神经科学家和一名经过验证的专家喜剧演员，变得中性和温和到非常有趣)。我们通过Nuldos面部分析软件评估了每个刺激的效价和强度的个人面部表情。该研究还采用了眼动追踪装置来检查注视，gaze,和每个任务的扫视运动。此外,在静息状态和使用4通道Nexus测谎仪设置暴露于剪辑后,监测测谎仪参数的变化.
快乐的面部表情分析，作为一个功能的评价有趣的剪辑，与中性视频有显著差异(p<0.001)。就测谎仪的变化而言，暴露于有趣vs.中性视频（p<0.5）。平均瞳孔大小和固定漂移明显较高和较低，分别,在接触有趣的视频（p<0.01）。qEEG数据显示，在暴露于有趣的剪辑后，位于左额颞叶网络（FTN）中的alpha频带的电流源密度（CSD）最高。此外,左FTN获得了θ相干性z分数的最高值，而测试版CSD主要落在显着性网络(SN)上。
这些初步数据支持这样的观点，即左FTN可以作为非侵入性神经调节的皮质中枢作为临床治疗情感障碍的单一或辅助疗法。需要进一步的研究来检验从本报告得出的假设。
The practicality of the idea whether the laughter-involved large-scale brain networks can be stimulated to remediate affective symptoms, namely depression, has remained elusive.
In this study, 25 healthy individuals were tested through 21-channel quantitative electroencephalography (qEEG) setup upon resting state and while submitted to standardized funny video clips (corated by two behavioral neuroscientists and a verified expert comedian, into neutral and mildly to highly funny). We evaluated the individuals\' facial expressions against the valence and intensity of each stimulus through the Nuldos face analysis software. The study also employed an eye-tracking setup to examine fixations, gaze, and saccadic movements upon each task. In addition, changes in polygraphic parameters were monitored upon resting state and exposure to clips using the 4-channel Nexus polygraphy setup.
The happy facial expression analysis, as a function of rated funny clips, showed a significant difference against neutral videos (p < 0.001). In terms of the polygraphic changes, heart rate variability and the trapezius muscle surface electromyography measures were significantly higher upon exposure to funny vs. neutral videos (p < 0.5). The average pupil size and fixation drifts were significantly higher and lower, respectively, upon exposure to funny videos (p < 0.01). The qEEG data revealed the highest current source density (CSD) for the alpha frequency band localized in the left frontotemporal network (FTN) upon exposure to funny clips. Additionally, left FTN acquired the highest value for theta coherence z-score, while the beta CSD predominantly fell upon the salience network (SN).
These preliminary data support the notion that left FTN may be targeted as a cortical hub for noninvasive neuromodulation as a single or adjunct therapy in remediating affective disorders in the clinical setting. Further studies are needed to test the hypotheses derived from the present report.
