尤因肉瘤(EWS)是一种高度侵袭性的恶性骨肿瘤,主要影响青少年和年轻人。尽管在某些情况下放化疗有效,转移性和复发性疾病患者的治愈率仍然很低。因此,迫切需要创新的治疗方法来应对与EWS治疗相关的挑战.表观遗传调控,生理过程中的一个关键因素,在控制细胞增殖中起着重要作用,保持基因完整性,和调节转录。最近的研究强调了异常表观遗传调控在EWS的启动和进展中的重要性。全面了解EWS与异常表观遗传调控之间的复杂相互作用对于推进临床药物开发至关重要。这篇综述旨在全面概述EWS中涉及的两个表观遗传靶标,整合各种治疗方式,为EWS的临床诊断和治疗提供创新的观点。
Ewing\'s sarcoma (EWS) is a highly aggressive malignant bone tumor primarily affecting adolescents and young adults. Despite the efficacy of chemoradiotherapy in some cases, the cure rate for patients with metastatic and recurrent disease remains low. Therefore, there is an urgent need for innovative therapeutic approaches to address the challenges associated with EWS treatment.
Epigenetic regulation, a crucial factor in physiological processes, plays a significant role in controlling cell proliferation, maintaining gene integrity, and regulating transcription. Recent studies highlight the importance of abnormal
epigenetic regulation in the initiation and progression of EWS. A comprehensive understanding of the intricate interactions between EWS and aberrant
epigenetic regulation is essential for advancing clinical drug development. This review aims to provide a comprehensive overview of both
epigenetic targets implicated in EWS, integrating various therapeutic modalities to offer innovative perspectives for the clinical diagnosis and treatment of EWS.