在二倍体生物中,每个细胞中一半的染色体来自父亲,一半来自母亲。通过以往的研究,发现父系染色体和母系染色体可以独立调节和表达,导致等位基因特异性表达(ASE)的出现。在这项研究中,我们基于RNA测序数据分析了高海拔人群和正常人群中等位基因的差异表达。通过基因簇分析和蛋白质相互作用网络分析,我们发现基因水平发生了一些变化,和一些负面影响。在研究期间,我们意识到钙调蛋白同源域可能与高海拔地区的长期生存有一定的相关性。高原环境以缺氧为特征,低气压,强烈的紫外线辐射,和低温。因此,适应过程中的遗传变化主要体现在这些特征上。高海拔一代的生活也与癌症高度相关,免疫性疾病,心血管疾病,神经系统疾病,内分泌疾病,和其他疾病。因此,高海拔地区的医疗系统应该更加关注这些疾病。
In diploid organisms, half of the chromosomes in each cell come from the father and half from the mother. Through previous studies, it was found that the paternal chromosome and the maternal chromosome can be regulated and expressed independently, leading to the emergence of allele specific expression (ASE). In this
study, we analyzed the differential expression of alleles in the high-altitude population and the normal population based on the RNA sequencing data. Through gene cluster analysis and protein interaction network analysis, we found some changes occurred at the gene level, and some negative effects. During the
study, we realized that the calmodulin homology domain may have a certain correlation with long-term survival at high altitude. The plateau environment is characterized by hypoxia, low air pressure, strong ultraviolet radiation, and low temperature. Accordingly, the genetic changes in the process of adaptation are mainly reflected in these characteristics. High altitude generation living is also highly related to cancer, immune disease, cardiovascular disease, neurological disease, endocrine disease, and other diseases. Therefore, the medical system in high altitude areas should pay more attention to these diseases.