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Abstract：
Long non-coding RNAs (LncRNAs) are a class of RNA molecules with nucleic acid lengths ranging from 200 bp to 100 kb that cannot code for proteins, which are diverse and widely expressed in both animals and plants. Scholars have found that lncRNAs can regulate human physiological processes at the gene and protein levels, mainly through the regulation of epigenetic, transcriptional and post-transcriptional levels of genes and proteins, as well as in the immune response by regulating the expression of immune cells and inflammatory factors, and thus participate in the occurrence and development of a variety of diseases. From the downstream targets of lncRNAs, we summarize the new research progress of lncRNA mechanisms other than miRNA sponges in recent years, aiming to provide new ideas and directions for the study of lncRNA mechanisms.
摘要：
长链非编码RNA（LncRNA）是一类RNA分子，其核酸长度范围为200bp至100kb，不能编码蛋白质，在动物和植物中广泛表达。学者们发现lncRNAs可以在基因和蛋白质水平上调节人体生理过程，主要通过表观遗传的调节，基因和蛋白质的转录和转录后水平，以及在免疫应答中通过调节免疫细胞和炎症因子的表达,从而参与各种疾病的发生发展。从lncRNAs的下游靶标中，我们总结了近年来除miRNA海绵外的lncRNA机制的新研究进展，旨在为lncRNA机制的研究提供新的思路和方向。
