背景:药物超敏反应是一个主要的全球公共卫生问题,在人群中患病率显著增加。这里,我们深入了解药物超敏反应领域的前沿热点和未来方向。
方法:基于使用CiteSpace的WebofScienceCoreCollection中与药物超敏反应相关的出版物来描绘知识图谱。国家的共现关系,研究所,作者,期刊,参考文献,和关键字构造。根据共生关系,热点和未来趋势概述。
结果:美国位居世界第一,中国是世界上唯一的发展中国家。Torres,马约加,和布兰卡是高产的作家。哈佛大学是研究出版物最多的机构。关键词共现分析建议在新兴原因中的应用,潜在机制,和临床诊断成为研究热点和发展前沿。
结论:关于药物超敏反应的研究正处于快速发展阶段,并且发现了聚乙二醇过敏反应报道的新趋势。开发算法以了解罪魁祸首药物的标准化过程,临床表现,和诊断方法将是未来的重点方向。此外,需要更好地理解具有免疫学精确表型定义和高通量平台的罪魁祸首药物的机制.
BACKGROUND: Drug hypersensitivity is a major global public health issue with a significant increase in prevalence in populations. Here, we provide a deep insight into the frontier hotspot and future direction in the field of drug hypersensitivity.
METHODS: A knowledge map is portrayed based on publications related to drug hypersensitivity from Web of Science Core Collection using CiteSpace. Co-occurrence relationships of countries, institutes, authors, journals, references, and keywords are constructed. According to the co-occurrence relationships, hotspots and future trends are overviewed.
RESULTS: The United States ranked first in the world and
China with the second highest publications was the only developing country. Torres, Mayorga, and Blanca were highly productive authors. Harvard University was the institution with the most research publications. Keywords co-occurrence analysis suggested applications in emerging causes, potential mechanisms, and clinical diagnosis as the research hotspots and development frontiers.
CONCLUSIONS: Research on drug hypersensitivity is in a rapid development stage and an emerging trend in reports of
anaphylaxis to polyethylene glycols is identified. Developing algorithms for understanding the standardization process of culprit drugs, clinical manifestations, and diagnostic methods will be the focus of future direction. In addition, a better understanding of the mechanisms to culprit drugs with immunological precise phenotypic definitions and high-throughput platforms is needed.