PDF(Pubmed)
Abstract：
BACKGROUND: Perioperative anaphylaxis (POA) can lead to significant complications. Therefore, accurate identification of allergens for POA patients is critical to ensure the safety of future surgical and anaesthetic procedures. Existing perioperative allergen detection methods face challenges in sensitivity and specificity. The passive mast cell activation test (pMAT) has recently emerged as a potential diagnostic tool. Our study aims to evaluate the diagnostic efficacy of pMAT for identifying perioperative allergens, with a focus on non-depolarising neuromuscular blocking agents, the most common culprits of POA.
METHODS: This prospective diagnostic accuracy study will measure the diagnostic accuracy of pMAT in POA patients. Participants will undergo skin testing (ST), basophil activation testing (BAT) and pMAT. The diagnostic validity of pMAT will be assessed based on the results of ST and BAT. The assessment of diagnostic accuracy will include sensitivity, specificity, likelihood ratios, and false-positive and false-negative rates while measurement of the consistency rate will assess reliability.
BACKGROUND: This study has been approved by the Institutional Review Board of China-Japan Friendship Hospital (2023-KY-247). Results will be disseminated through academic presentations and peer-reviewed journal publications and will provide valuable scientific data and some new insights into the diagnostic accuracy of pMAT.
METHODS: This prospective diagnostic accuracy study will measure the diagnostic accuracy of pMAT in POA patients. Participants will undergo skin testing (ST), basophil activation testing (BAT) and pMAT. The diagnostic validity of pMAT will be assessed based on the results of ST and BAT. The assessment of diagnostic accuracy will include sensitivity, specificity, likelihood ratios, and false-positive and false-negative rates while measurement of the consistency rate will assess reliability.
BACKGROUND: This study has been approved by the Institutional Review Board of China-Japan Friendship Hospital (2023-KY-247). Results will be disseminated through academic presentations and peer-reviewed journal publications and will provide valuable scientific data and some new insights into the diagnostic accuracy of pMAT.
摘要：
背景：围手术期过敏反应（POA）可导致严重的并发症。因此,准确识别POA患者的过敏原对于确保未来手术和麻醉程序的安全性至关重要。现有的围手术期过敏原检测方法在敏感性和特异性方面面临挑战。被动肥大细胞激活测试（pMAT）最近已成为潜在的诊断工具。我们的研究旨在评估pMAT对围手术期过敏原的诊断功效，专注于非去极化神经肌肉阻断剂，最常见的POA罪魁祸首。
方法：这项前瞻性诊断准确性研究将测量pMAT在POA患者中的诊断准确性。参与者将接受皮肤测试（ST），嗜碱性粒细胞激活测试（BAT）和pMAT。将根据ST和BAT的结果评估pMAT的诊断有效性。诊断准确性的评估将包括灵敏度，特异性，似然比，以及假阳性和假阴性率，而一致性率的测量将评估可靠性。
背景：本研究已获得中日友好医院机构审查委员会（2023-KY-247）的批准。结果将通过学术演讲和同行评审的期刊出版物进行传播，并将提供有价值的科学数据以及对pMAT诊断准确性的一些新见解。
方法：这项前瞻性诊断准确性研究将测量pMAT在POA患者中的诊断准确性。参与者将接受皮肤测试（ST），嗜碱性粒细胞激活测试（BAT）和pMAT。将根据ST和BAT的结果评估pMAT的诊断有效性。诊断准确性的评估将包括灵敏度，特异性，似然比，以及假阳性和假阴性率，而一致性率的测量将评估可靠性。
背景：本研究已获得中日友好医院机构审查委员会（2023-KY-247）的批准。结果将通过学术演讲和同行评审的期刊出版物进行传播，并将提供有价值的科学数据以及对pMAT诊断准确性的一些新见解。
