背景:环境细颗粒物(PM2.5)和臭氧(O3)对焦虑症(AD)的短期不利影响仍然没有定论。
方法:我们应用了一项个体水平的时间分层病例交叉研究,其中包括2019-2021年广东省ADs门诊126112次,中国将调查短期PM2.5和O3暴露与ADs门诊就诊的关系,并估计华南地区的超额门诊量。通过从经过验证的数据集中提取网格数据(空间分辨率:1km×1km)来进行每日住宅空气污染物暴露评估。我们采用条件逻辑回归模型来量化关联和超额门诊量。
结果:单污染物模型的结果表明,PM2.5和O3暴露量每增加10μg/m3,与3.14%显着相关(95%置信区间:2.47%,3.81%)和0.88%(0.49%,1.26%)AD的门诊就诊几率增加,分别。这些关联在2-污染物模型中保持稳健。由PM2.5和O3暴露引起的门诊就诊比例分别高达7.20%和8.93%,分别。老年人似乎更容易接触PM2.5,尤其是在凉爽的季节,反复门诊就诊的受试者更容易受到O3暴露的影响。
结论:由于我们的研究对象来自中国的一家医院,在将我们的发现推广到其他地区时,应该谨慎。
结论:短期暴露于环境PM2.5和O3与ADs门诊就诊的几率显着相关,这可能导致大量的门诊就诊。
BACKGROUND: The short-term adverse effects of ambient fine particulate matter (PM2.5) and ozone (O3) on anxiety disorders (ADs) remained inconclusive.
METHODS: We applied an individual-level time-stratified case-crossover study, which including 126,112 outpatient visits for ADs during 2019-2021 in Guangdong province,
China, to investigate the association of short-term exposure to PM2.5 and O3 with outpatient visits for ADs, and estimate excess outpatient visits in South
China. Daily residential air pollutant exposure assessments were performed by extracting grid data (spatial resolution: 1 km × 1 km) from validated datasets. We employed the conditional logistic regression model to quantify the associations and excess outpatient visits.
RESULTS: The results of the single-pollutant models showed that each 10 μg/m3 increase of PM2.5 and O3 exposures was significantly associated with a 3.14 % (95 % confidence interval: 2.47 %, 3.81 %) and 0.88 % (0.49 %, 1.26 %) increase in odds of outpatient visits for ADs, respectively. These associations remained robust in 2-pollutant models. The proportion of outpatient visits attributable to PM2.5 and O3 exposures was up to 7.20 % and 8.93 %, respectively. Older adults appeared to be more susceptible to PM2.5 exposure, especially in cool season, and subjects with recurrent outpatient visits were more susceptible to O3 exposure.
CONCLUSIONS: As our study subjects were from one single hospital in
China, it should be cautious when generalizing our findings to other regions.
CONCLUSIONS: Short-term exposure to ambient PM2.5 and O3 was significantly associated with a higher odds of outpatient visits for ADs, which can contribute to considerable excess outpatient visits.