■光老化表现为较深的皱纹和较大的毛孔。已经尝试使用各种激光来恢复光老化皮肤的活力,包括分馏激光器,这是一种流行的光子嫩肤疗法。嫩肤的一个新突破是1927nm分数thulium光纤激光器(FTL),基于激光和光的治疗选择。尽管FTL具有有效性和安全性,但其治疗光老化的临床数据有限。本研究旨在评估FTL的临床有效性和安全性。
■FitzpatrickII-IV型皮肤具有轻度至中度光老化征象的受试者参加了这项前瞻性研究。每隔一个月,患者接受了三次全脸治疗。皱纹,斑点,纹理,毛孔,黑色素指数,红斑指数(MI和EI),用非侵入性工具测量皮肤弹性和水合作用。比较基线和所有治疗后一个月的表皮厚度和超声检查的真皮密度。在基线和最终随访时,两名独立评估者对光老化量表(GSP)的全球评分进行了评估。次要结果包括10点视觉模拟量表(VAS)的患者疼痛评分,以及总体满意度。每次治疗后,观察到不良事件.
■共有27名受试者(24名女性和3名男性)患有FitzpatrickII至IV型皮肤,平均年龄为44.41(范围33-64)。结果表明,治疗后表皮厚度明显改善。黑色素指数的显著改善,注意到皮肤弹性和皱纹。对12名受试者的分析报告(44%)表明他们的皮肤感觉更亮。未观察到炎症后色素沉着过度改变或不良事件。70%的患者报告“满意”或“非常满意”。
■在这项研究中,发现FTL是治疗光老化的安全有效的治疗选择。
UNASSIGNED: Photoaging manifests as deeper
wrinkles and larger pores. It has been tried to rejuvenate photoaging skin using a variety of lasers, including fractionated lasers, which are a popular photorejuvenation treatment. A new breakthrough for skin rejuvenation is the 1927 nm fractional thulium fiber laser (FTL), a laser and light-based treatment option. Clinical data regarding the FTL for treating photoaging are limited despite its effectiveness and safety. This study is aim to evaluate FTL\' clinical effectiveness and safety.
UNASSIGNED: Fitzpatrick skin types II-IV subjects with mild to moderate photoaging signs were enrolled in this prospective study. At intervals of one month, patients received three full face treatments.
Wrinkles, spots, texture, pores, melanin index, erythema index (MI and EI), skin elasticity and hydration were measured with non-invasive tool. The epidermal thickness and dermal density on ultrasonography were compared between baseline and one month after all treatment sessions. The Global Score for Photoaging scale (GSP) was rated by two independent evaluators at the baseline and final follow-up visit. Secondary outcomes included patient-rated pain on a 10-point visual analog scale (VAS), as well as overall satisfaction. Following each treatment, adverse events were noted.
UNASSIGNED: Totally 27 subjects (24 females and 3 males) with Fitzpatrick skin types II to IV and a mean age of 44.41 (range33-64) were enrolled. Results suggests that the epidermal thickness has significantly improved after treatment. Statistically significant improvements in melanin index, skin elasticity and
wrinkles were noted. An analysis of 12 subjects\' reports (44%) suggested their skin felt brighter. No post-inflammatory hyperpigmentation changes or adverse events were observed. 70% patients reporting \"satisfied\" or \"extremely satisfied\".
UNASSIGNED: In this study, FTL was found to be a safe and effective treatment option for treating photoaging.