化妆品,药品和化妆品之间的桥梁,含有生物活性成分,可以改善皮肤的整体外观。作为市场,可访问性,药妆品的受欢迎程度越来越高,了解此类产品的安全性和有效性至关重要。本系统评价旨在检查已发表的涉及使用药妆抗衰老的临床研究,以提供基于现有疗效和安全性数据的循证建议。PubMed,Embase,和Cochrane于2023年1月1日使用PRISMA指南进行了系统搜索。使用牛津循证医学中心指南对证据强度进行分级。根据现有文献的质量提出临床建议。总共鉴定了153篇关于使用药妆来治疗抗衰老的文章。经过标题筛选,摘要,和全文,涉及1236名患者的32项研究符合纳入标准,包括20项维生素C随机对照试验(RCTs)和12项非随机开放标签临床试验,视黄醇,Bakuchol,四氢茉莉酸,生长因子,雌二醇丙酸甲酯,知母皂苷A-III(TA-III),原儿茶酸,特殊银杏,和茉莉米穗提取物。用于抗衰老的视黄醇和维生素C获得了A级推荐。雌二醇丙酸甲酯,bakuchiol,四氢茉莉酸,生长因子的推荐等级为C。由于缺乏证据,其余成分被指定为不确定的推荐等级。纳入审查的药效药具有良好的安全性,很少发生重大不良事件。该评论分析了许多不同的成分,为消费者和医生使用药妆来抗衰老提供了基于证据的决策方法。我们审查的局限性包括数量有限的随机对照试验,以及需要关于每种药效药的疗效和安全性的长期数据。需要未来的研究来确定药妆的长期有效性和安全性。
Cosmeceuticals, the bridge between pharmaceuticals and cosmetics, contain biologically active ingredients that may improve the skin\'s overall appearance. As the market, accessibility, and popularity of cosmeceuticals increase, it is essential to understand the safety and efficacy of such products. This systematic
review aims to examine published clinical studies involving the use of cosmeceuticals for antiaging to provide evidence-based recommendations based on available efficacy and safety data. PubMed, Embase, and Cochrane were systematically searched on January 1, 2023 using PRISMA guidelines. Strength of evidence was graded using the Oxford Centre for Evidence-Based Medicine guidelines. Clinical recommendations were made based on the quality of the existing literature. A total of 153 articles regarding the use of cosmeceuticals for treatment of antiaging were identified. After screening of titles, abstracts, and full text, 32 studies involving 1236 patients met inclusion criteria, including 20 randomized controlled trials (RCTs) and 12 non-randomized open-label clinical trials for Vitamin C, Retinol, Bakuchiol, Tetrahydrojasmonic acid, Growth Factors, Methyl Estradiolpropanoate, Timosaponin A-III (TA-III), Protocatechuic acid, Grammatophyllum speciosum, and Jasmine rice panicle extract. Retinol and vitamin C for antiaging received a Grade A for recommendation. Methyl estradiolpropanoate, bakuchiol, tetrahydrojasmonic acid, and growth factors received a recommendation grade of C. The remaining ingredients were assigned an inconclusive grade of recommendation due to lack of evidence. Cosmeceuticals included in the
review had favorable safety profiles with few significant adverse events. The
review analyzes numerous different ingredients to provide an evidence-based approach to decision-making for consumers and physicians on the use of cosmeceuticals for antiaging. Limitations to our
review include a limited number of randomized controlled trials and a need for long-term data on each cosmeceutical\'s efficacy and safety. Future research is needed to establish the long-term effectiveness and safety of cosmeceuticals.