PDF(Pubmed)
Abstract：
Photoaging, the primary cause of skin aging damage, results from chronic ultraviolet (UV) exposure, leading to dryness and wrinkle formation. Nutritional intervention has emerged as a practical approach for preventing and addressing the effect of skin photoaging. The primary aromatic compound isolated from clove oil, isoeugenol (IE), has antibacterial, anti-inflammatory, and antioxidant qualities that work to effectively restrict skin cancer cell proliferation. This investigation delved into the advantages of IE in alleviating skin photoaging using UVB-irradiated skin fibroblasts and female SKH-1 hairless mouse models. IE alleviated UVB-induced photodamage in Hs68 dermal fibroblasts by inhibiting matrix metalloproteinase secretion and promoting extracellular matrix synthesis. In photoaged mice, dietary IE reduced wrinkles, relieved skin dryness, inhibited epidermal thickening, and prevented collagen loss. Additionally, the intestinal dysbiosis caused by prolonged UVB exposure was reduced with an IE intervention. The results of Spearman\'s analysis showed a strong correlation between skin photoaging and gut microbiota. Given the almost unavoidable UVB exposure in contemporary living, this research demonstrated the efficacy of dietary IE in reversing skin photoaging, presenting a promising approach to tackle concerns related to extrinsic skin aging.
摘要：
光老化,皮肤老化损伤的主要原因,慢性紫外线（UV）暴露的结果，导致干燥和皱纹的形成。营养干预已成为预防和解决皮肤光老化影响的实用方法。从丁香油中分离出的伯芳族化合物，异丁香酚（IE），具有抗菌性，抗炎,和抗氧化品质，有效地限制皮肤癌细胞的增殖。这项研究探讨了IE在使用UVB照射的皮肤成纤维细胞和雌性SKH-1无毛小鼠模型缓解皮肤光老化方面的优势。IE通过抑制基质金属蛋白酶分泌和促进细胞外基质合成减轻UVB诱导的Hs68真皮成纤维细胞光损伤。在光老化的小鼠中，饮食IE减少皱纹，缓解皮肤干燥，抑制表皮增厚，并防止胶原蛋白流失。此外,通过IE干预，由长期UVB暴露引起的肠道生态失调减少。Spearman分析结果显示皮肤光老化与肠道菌群之间存在很强的相关性。鉴于当代生活中几乎不可避免的UVB暴露，这项研究证明了饮食IE在逆转皮肤光老化方面的功效，提出了一种有希望的方法来解决与外在皮肤老化有关的问题。
