目的:听力在我们控制语音的能力中起着重要作用,听觉反馈的扰动会导致声音产生的补偿性变化。听觉皮层(AC)已被提出作为这种行为的重要媒介,但缺乏因果证据.我们在动物模型中测试了这个,假设AC是声乐自我监测和反馈依赖控制所必需的,在发声过程中改变AC的活动会干扰声音控制。
方法:我们用双侧AC电极阵列植入了两只猴(Callithrixjacchus)。在发声的随机子集期间,在改变声音反馈或电刺激AC的同时,从发声的marmosets中记录声学信号。反馈通过实时频移改变,并通过耳机和传递到各个电极的电刺激呈现。我们分析了录音,以测量在移位反馈和刺激过程中声乐声学的变化,并确定它们的相互作用。结果与刺激部位的位置和频率调谐相关。
结果:与以前的结果一致,我们发现电刺激会引起声乐产生的变化。右半球的结果更强,但随着较低的电流或重复刺激而下降。同时刺激和移位的反馈显着改变了部分部位的声音控制,一些人减少反馈补偿,另一些人增加反馈补偿。在靠近声音频率的位置,抑制补偿的可能性更大。
结论:结果提供了因果证据,证明AC参与了反馈依赖的声音控制,这足以也可能是必要的,以推动声乐制作的变化。
方法:N/A喉镜,133:1-10,2023年。
Hearing plays an important role in our ability to control voice, and perturbations in auditory feedback result in compensatory changes in vocal production. The auditory cortex (AC) has been proposed as an important mediator of this behavior, but causal evidence is lacking. We tested this in an animal model, hypothesizing that AC is necessary for vocal self-monitoring and feedback-dependent control, and that altering activity in AC during
vocalization will interfere with vocal control.
We implanted two marmoset monkeys (Callithrix jacchus) with bilateral AC electrode arrays. Acoustic signals were recorded from vocalizing marmosets while altering vocal feedback or electrically stimulating AC during random subsets of vocalizations. Feedback was altered by real-time frequency shifts and presented through headphones and electrical stimulation delivered to individual electrodes. We analyzed recordings to measure changes in vocal acoustics during shifted feedback and stimulation, and to determine their interaction. Results were correlated with the location and frequency tuning of stimulation sites.
Consistent with previous results, we found electrical stimulation alone evoked changes in vocal production. Results were stronger in the right hemisphere, but decreased with lower currents or repeated stimulation. Simultaneous stimulation and shifted feedback significantly altered vocal control for a subset of sites, decreasing feedback compensation at some and increasing it at others. Inhibited compensation was more likely at sites closer to vocal frequencies.
Results provide causal evidence that the AC is involved in feedback-dependent vocal control, and that it is sufficient and may also be necessary to drive changes in vocal production.
N/A Laryngoscope, 133:1-10, 2023.