由于其安全性,便利性,低成本和良好的合规性,口服给药引起了很多关注。然而,许多口服药物的功效仅限于其在胃肠道中不令人满意的生物利用度。关键和最被忽视的因素之一是共生的肠道微生物群,它可以通过参与口服药物的生物转化来调节口服药物的生物利用度,影响药物运输过程并改变一些胃肠道特性。在这次审查中,我们总结了肠道菌群与口服药物生物利用度之间可能关系的现有研究,这可能为新型药物递送系统的设计或个性化医疗的实现提供了很好的思路和有用的指导。
Due to its safety, convenience, low cost and good compliance, oral administration attracts lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory bioavailability in the gastrointestinal tract. One of the critical and most overlooked factors is the symbiotic gut microbiota that can modulate the bioavailability of oral drugs by participating in the biotransformation of oral drugs, influencing the drug transport process and altering some gastrointestinal properties. In this review, we summarized the existing research investigating the possible relationship between the gut microbiota and the bioavailability of oral drugs, which may provide great ideas and useful instructions for the design of novel drug delivery systems or the achievement of personalized medicine.