关键词： 5-ASA, 5-aminosalicylic acid AA, ascorbic acid ABC, ATP-binding cassette ACS, amphipathic chitosan derivative AMI, amiodarone AQP4, aquaporin 4 AR, azoreductase ASP, amisulpride BBR, berberine BCRP, breast cancer resistance protein BCS, biopharmaceutics classification system BDDCS, the biopharmaceutics drug disposition classification system BDEPT, the bacteria-directed enzyme prodrug therapy BSH, bile salt hydrolase Bioavailability CA, cholic acid CDCA, chenodeoxycholic acid CPP, cell-penetrating peptide CS, chitosan Colon-specific drug delivery system DCA, deoxycholic acid DRPs, digoxin reduction products EcN, Escherichia coli Nissle 1917 FA, folate FAO, Food and Agriculture Organization of the United Nations GCDC, glycochenodeoxycholate GL, glycyrrhizic acid Gut microbiota HFD, high fat diet HTC, hematocrit IBD, inflammatory bowel disease LCA, lithocholic acid LPS, lipopolysaccharide MATEs, multidrug and toxin extrusion proteins MDR1, multidrug resistance gene 1 MDR1a, multidrug resistance protein-1a MKC, monoketocholic acid MPA, mycophenolic acid MRP2, multidrug resistance-associated protein 2 NEC, necrotizing enterocolitis NMEs, new molecular entities NRs, nitroreductases NSAIDs, non-steroidal anti-inflammatory drugs NaDC, sodium deoxycholate NaGC, sodium glycholate OATs, organic anion transporters OCTNs, organic zwitterion/cation OCTs, organic cation transporters Oral drugs P-gp, P-glycoprotein PD, Parkinson's disease PPIs, proton pump inhibitors PT, pectin PWSDs, poorly water-soluble drugs Probiotics RA, rheumatoid arthritis RBC, red blood cell SCFAs, short-chain fatty acids SGLT-1, sodium-coupled glucose transporter 1 SLC, solute carrier SLN, solid lipid nanoparticle SP, sulfapyridine SSZ, sulfasalazine SVCT-1/2, the sodium-dependent vitamin C transporter-1/2 T1D, type 1 diabetes T1DM, type 1 diabetes mellitus T2D, type 2 diabetes TCA, taurocholate TCDC, taurochenodeoxycholate TDCA, taurodeoxycholate TLCA, taurolithocholate TME, the tumor microenvironment UDC, ursodeoxycholic acid WHO, World Health Organization an OTC drug, an over-the-counter drug cgr operon, cardiac glycoside reductase operon dhBBR, dihydroberberine pKa, dissociation constant the GI tract, the gastrointestinal tract

来  源：   DOI：10.1016/j.apsb.2020.09.013   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
Due to its safety, convenience, low cost and good compliance, oral administration attracts lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory bioavailability in the gastrointestinal tract. One of the critical and most overlooked factors is the symbiotic gut microbiota that can modulate the bioavailability of oral drugs by participating in the biotransformation of oral drugs, influencing the drug transport process and altering some gastrointestinal properties. In this review, we summarized the existing research investigating the possible relationship between the gut microbiota and the bioavailability of oral drugs, which may provide great ideas and useful instructions for the design of novel drug delivery systems or the achievement of personalized medicine.
摘要：
由于其安全性,便利性，低成本和良好的合规性，口服给药引起了很多关注。然而,许多口服药物的功效仅限于其在胃肠道中不令人满意的生物利用度。关键和最被忽视的因素之一是共生的肠道微生物群，它可以通过参与口服药物的生物转化来调节口服药物的生物利用度，影响药物运输过程并改变一些胃肠道特性。在这次审查中,我们总结了肠道菌群与口服药物生物利用度之间可能关系的现有研究，这可能为新型药物递送系统的设计或个性化医疗的实现提供了很好的思路和有用的指导。
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