肠道菌群对口服药物生物利用度的影响。
关键词: 5-ASA, 5-aminosalicylic acid AA, ascorbic acid ABC, ATP-binding cassette ACS, amphipathic chitosan derivative AMI, amiodarone AQP4, aquaporin 4 AR, azoreductase ASP, amisulpride BBR, berberine BCRP, breast cancer resistance protein BCS, biopharmaceutics classification system BDDCS, the biopharmaceutics drug disposition classification system BDEPT, the bacteria-directed enzyme prodrug therapy BSH, bile salt hydrolase Bioavailability CA, cholic acid CDCA, chenodeoxycholic acid CPP, cell-penetrating peptide CS, chitosan Colon-specific drug delivery system DCA, deoxycholic acid DRPs, digoxin reduction products EcN, Escherichia coli Nissle 1917 FA, folate FAO, Food and Agriculture Organization of the United Nations GCDC, glycochenodeoxycholate GL, glycyrrhizic acid Gut microbiota HFD, high fat diet HTC, hematocrit IBD, inflammatory bowel disease LCA, lithocholic acid LPS, lipopolysaccharide MATEs, multidrug and toxin extrusion proteins MDR1, multidrug resistance gene 1 MDR1a, multidrug resistance protein-1a MKC, monoketocholic acid MPA, mycophenolic acid MRP2, multidrug resistance-associated protein 2 NEC, necrotizing enterocolitis NMEs, new molecular entities NRs, nitroreductases NSAIDs, non-steroidal anti-inflammatory drugs NaDC, sodium deoxycholate NaGC, sodium glycholate OATs, organic anion transporters OCTNs, organic zwitterion/cation OCTs, organic cation transporters Oral drugs P-gp, P-glycoprotein PD, Parkinson's disease PPIs, proton pump inhibitors PT, pectin PWSDs, poorly water-soluble drugs Probiotics RA, rheumatoid arthritis RBC, red blood cell SCFAs, short-chain fatty acids SGLT-1, sodium-coupled glucose transporter 1 SLC, solute carrier SLN, solid lipid nanoparticle SP, sulfapyridine SSZ, sulfasalazine SVCT-1/2, the sodium-dependent vitamin C transporter-1/2 T1D, type 1 diabetes T1DM, type 1 diabetes mellitus T2D, type 2 diabetes TCA, taurocholate TCDC, taurochenodeoxycholate TDCA, taurodeoxycholate TLCA, taurolithocholate TME, the tumor microenvironment UDC, ursodeoxycholic acid WHO, World Health Organization an OTC drug, an over-the-counter drug cgr operon, cardiac glycoside reductase operon dhBBR, dihydroberberine pKa, dissociation constant the GI tract, the gastrointestinal tract
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DOI:10.1016/j.apsb.2020.09.013
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