目的:肝炎病毒感染正在影响全球数百万人,导致死亡,残疾,和相当大的支出。丙型肝炎病毒(HCV)的慢性感染可导致严重的公共卫生问题,因为它们的高患病率和不良的长期临床结果。因此,研究了在记忆效应的影响下涉及部分免疫的丙型肝炎病毒的分数阶流行模型,以了解HCV感染的传播方式和患病率。研究HCV的传播动力学使该问题更加有趣。在这项研究中检查了HCV流行模型和全球动态。使用下一代矩阵技术计算HCV模型的基本复制数。我们使用再现数确定模型的全球动态,Lyapunov函数方法,和劳斯-赫维兹标准。模型的繁殖数显示了疾病的进展。
方法:建立了HCV感染的分数微分方程模型。最大相关参数,比如分数幂,HCV传播率,再现数,等。,影响动态过程,已被合并。使用分数阶Adams方法获得模型的数值解。最后,数值模拟支持理论结论,显示了两者之间的伟大协议。
结果:在分数阶HCV感染模型中,记忆效应,这在经典模型中是看不到的,在图表上显示,以便可以看到疾病动力学和矢量区室。我们发现分数阶HCV感染模型比常规衍生物具有更多的自由度。分数阶导数,这可能是最好和最可靠的,比经典秩序更好地解释了身体方法。
结论:本研究建模并分析了分数阶HCV感染模型。目前的方法导致更好地了解HCV在人群中的传播,这导致了对其传播和控制的重要见解,如不同年龄组更好的治疗剂量,确定最佳控制措施,改善健康,延长寿命,降低HCV传播的风险,有效提高HCV患者的生活质量。分数阶HCV感染模型的建立,这提供了对HCV传播动力学的更好理解,并导致对更好的治疗剂量的重要见解,最佳控制措施的识别,并最终改善HCV患者的生活质量,是这项研究的主要结果。
OBJECTIVE: Hepatitis virus infections are affecting millions of people worldwide, causing death, disability, and considerable expenditure. Chronic infection with hepatitis C virus (HCV) can cause severe public health problems because of their high prevalence and poor long-term clinical outcomes. Thus a fractional-order epidemic model of the hepatitis C virus involving partial immunity under the influence of memory effect to know the transmission patterns and prevalence of HCV infection is studied. Investigating the transmission dynamics of HCV makes the issue more interesting. The HCV epidemic model and worldwide dynamics are examined in this study. Calculate the basic reproduction number for the HCV model using the next-generation matrix technique. We determine the model\'s global dynamics using reproduction numbers, the Lyapunov functional approach, and the Routh-Hurwitz criterion. The model\'s reproduction number shows how the disease progresses.
METHODS: A fractional differential equation model of HCV infection has been created. Maximum relevant parameters, such as fractional power, HCV transmission rate, reproduction number, etc., influencing the dynamic process, have been incorporated. The model\'s numerical solutions are obtained using the fractional Adams method. Finally, numerical simulations support the theoretical conclusions, showing the great agreement between the two.
RESULTS: In the fractional-order HCV infection model, the memory effect, which is not seen in the classical model, was shown on graphs so that disease dynamics and vector compartments could be seen. We found that the fractional-order HCV infection model has more stages of freedom than regular derivatives. Fractional-order derivations, which may be the best and most reliable, explained bodily approaches better than classical order.
CONCLUSIONS: The current study modeled and analyzed a fractional-order HCV infection model. The current approach results in a much better understanding of HCV transmission in a population, which leads to important insights into its spread and control, such as better treatment dosage for different age groups, identifying the best control measure, improving health, prolonging life, reducing the risk of HCV transmission, and effectively increasing the quality of life of HCV patients. The creation of a fractional-order HCV infection model, which provides a better understanding of HCV transmission dynamics and leads to significant insights for better treatment dosages, identification of optimal control measures, and ultimately improvement of the quality of life for HCV patients, is the study\'s major outcome.