■射精受中枢神经系统调节。然而,原发性阴道内射精(PIAJ)的中枢病理生理学尚不清楚.本研究旨在检查PIAJ基础上的区域大脑活动和功能连通性的变化。从2020年9月至2022年9月,共有20名PIAJ患者和16名健康对照(HCs)在男科注册,南京鼓楼医院(南京,中国)。从所有参与者获取磁共振成像数据,然后进行预处理。低频波动(fALFF)的分数振幅测量,区域同质性(ReHo),计算并比较各组间的功能连接(FC).与HC相比,PIAJ患者的左前肌fALFF值增加。此外,PIAJ患者显示左前肌ReHo值增加,左中央后回,左侧枕上回,左钙裂缝,右前叶,右颞中回,左顶叶下回的ReHo值降低,与HCs相比。最后,在PIAJ患者中fALFF和ReHo值改变的脑区显示FC增加,皮质区域广泛,其中包括额叶,顶叶,temporal,和枕骨区域,与HCs相比。总之,增加了顶叶的局部大脑活动,temporal,和枕骨区域,这些大脑区域之间的FC增加,可能与PIAJ事件有关。
UNASSIGNED: Ejaculation is regulated by the central nervous system. However, the central pathophysiology of primary intravaginal anejaculation (PIAJ) is unclear. The present study aimed to examine the changes in regional brain activity and functional connectivity underlying PIAJ. A total of 20 PIAJ patients and 16 healthy controls (HCs) were enrolled from September 2020 to September 2022 in the Department of Andrology, Nanjing Drum Tower Hospital (Nanjing,
China). Magnetic resonance imaging data were acquired from all participants and then were preprocessed. The measures of fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and functional connectivity (FC) were calculated and compared between the groups. PIAJ patients showed increased fALFF values in the left precuneus compared with HCs. Additionally, PIAJ patients showed increased ReHo values in the left precuneus, left postcentral gyrus, left superior occipital gyrus, left calcarine fissure, right precuneus, and right middle temporal gyrus, and decreased ReHo values in the left inferior parietal gyrus, compared with HCs. Finally, brain regions with altered fALFF and ReHo values in PIAJ patients showed increased FC with widespread cortical regions, which included the frontal, parietal, temporal, and occipital regions, compared with HCs. In conclusion, increased regional brain activity in the parietal, temporal, and occipital regions, and increased FC between these brain regions, may be associated with PIAJ occurrence.