目的:探讨RBP4rs3758539基因型与代谢综合征危险因素之间的联系,以及这种遗传变异的影响是否显示出任何潜在的种族差异。
方法:此荟萃分析遵循PRISMA指南,并在PROSPERO注册(注册号:CRD42023407999)。PubMed,WebofScience,Embase,科克伦图书馆,谷歌学者,Airiti图书馆和CINAHL数据库用于研究搜索,直到2023年10月。我们使用JoannaBriggs研究所检查表评估了方法学质量,并使用随机效应荟萃分析确定了相关性。
结果:结果表明,rs3758539GA/AA基因型的个体具有更高的风险特征,包括较低的高密度脂蛋白水平[相关性:-0.045,95%置信区间(CI):-0.080至-0.009,p=.015,I2=46.9%]和较高的体重指数(相关性:0.117,95%CI:0.036-0.197,p=.005,I2=82.0%),体脂(相关性:0.098,95%CI:0.004-0.191,p=0.041,I2=64.0%),和低密度脂蛋白水平(相关性:0.074,95%CI:0.010-0.139,p=0.024,I2=0%),与GG基因型相比,正在发展的代谢综合征。亚组分析保持rs3758539GA/AA基因型与体重指数之间的显着正相关(相关性:0.163,95%CI:0.031-0.289,p=0.016,I2=88.9%),但与高密度脂蛋白水平呈负相关(相关性:-0.047,95%CI:-0.087至-0.006,p=0.025,I2=65.7%)。
结论:当前的荟萃分析支持RBP4rs3758539GA/AA基因型与代谢综合征之间的显著联系。
OBJECTIVE: To explore the link between the RBP4 rs3758539 genotype and metabolic syndrome risk factors and whether the impact of this genetic variation displays any potential race discrepancy.
METHODS: This meta-analysis followed the PRISMA guidelines and was registered with PROSPERO (registration no. CRD42023407999). PubMed, Web of Science, Embase, Cochrane Library, Google Scholar, Airiti Library and CINAHL databases were used for the study search until October 2023. We evaluated the methodological quality using the Joanna Briggs Institute checklist and determined the correlation using a random-effects meta-analysis.
RESULTS: The results indicated that individuals with the rs3758539 GA/AA genotype had a higher risk profile, including lower high-density lipoprotein levels [correlation: -0.045, 95% confidence interval (CI): -0.080 to -0.009, p = .015, I2 = 46.9%] and higher body mass index (correlation: 0.117, 95% CI: 0.036-0.197, p = .005, I2 = 82.0%), body fat (correlation: 0.098, 95% CI: 0.004-0.191, p = .041, I2 = 64.0%), and low-density lipoprotein levels (correlation: 0.074, 95% CI: 0.010-0.139, p = .024, I2 = 0%), of developing metabolic syndrome than those with the GG genotype. The subgroup analysis maintained a significantly positive correlation between the rs3758539 GA/AA genotype and body mass index (correlation: 0.163, 95% CI: 0.031-0.289, p = .016, I2 = 88.9%) but a negative correlation with high-density lipoprotein levels (correlation: -0.047, 95% CI: -0.087 to -0.006, p = .025, I2 = 65.7%) in the Asian group only.
CONCLUSIONS: The current meta-analysis supports a significant link between the RBP4 rs3758539 GA/AA genotype and the metabolic syndrome.