目的:这项回顾性研究旨在显示在7年的时间内,在涉及肾静脉的下腔静脉平滑肌肉瘤(IVCL)的根治性切除术中保留肾功能的做法。
方法:2009年2月至2017年2月,在北京协和医院手术治疗了10例(6例女性,中位年龄49岁)累及肾静脉的IVCL患者。所有患者均进行了整体切除,使用一种新方法:肾孔静脉成形术(VRO)保留了8例患者的肾脏流出。有关患者详细信息的数据,术前准备,外科手术,术后恢复,并对随访结果进行回顾性分析。
结果:计算机断层扫描和术中检查显示,除患者4外,所有病例均涉及肾静脉汇合,但未侵犯。所有患者均接受了根治性整块肿瘤切除术;仅对一名肿瘤侵犯右肾静脉的患者(患者4)进行了右肾切除术。平均手术时间为358分钟,平均失血量为1935mL。在中位随访54.5个月时,5年局部复发,远处转移,总生存率,无病生存率为20%,10%,68.6%,38.1%,分别。
结论:肾孔静脉成形术是保留肾静脉和重建肾流出道的有效方法。
OBJECTIVE: This retrospective study aimed to show the practice of preserving renal function during curative resection of inferior vena cava leiomyosarcoma (IVCL) involving the renal veins at a single institution over a 7 year period.
METHODS: From February 2009 to February 2017, 10 patients (6 women; median age 49 years) with IVCL involving the renal veins were treated surgically at Peking Union Medical College Hospital. En bloc resections were performed in all patients, and the renal outflows were preserved in eight patients using a new method: venoplasty of the renal ostia (VRO). Data regarding patient details, pre-operative preparation, surgical procedures, post-operative recovery, and follow-up results were obtained and reviewed retrospectively.
RESULTS: Computed tomography and intra-operative examinations revealed that renal vein confluences were involved but not invaded in all cases except Patient 4. All patients underwent curative en bloc tumour excision; a right nephrectomy was performed in only one patient (Patient 4) whose tumour invaded the right renal vein. The mean operation time was 358 min and the mean blood loss 1935 mL. At a median follow-up of 54.5 months, the 5 year local recurrence, distant metastasis, overall survival, and disease-free survival rates were 20%, 10%, 68.6%, and 38.1%, respectively.
CONCLUSIONS: Venoplasty of the renal ostia is an effective method of preserving the renal veins and reconstructing renal outflow.