在人类中很少见感染流感链球菌,目前对感染的临床表现和药敏试验的研究还很有限。这里,我们从湖南省人民医院膀胱癌患者的尿液中分离出了流球菌,这是从尿液中分离出的第一例河豚。全自动微生物鉴定系统和基质辅助激光解吸/电离飞行时间质谱(MALDI-TOFMS)将该细菌鉴定为流感阴道球菌,置信水平为99.9%。VITEK-2Compact全自动微生物药敏分析系统表明,它对替加环素最敏感,万古霉素,quinupristin/dalfopristin,利奈唑胺,对红霉素有中度敏感性,左氧氟沙星,环丙沙星,氨苄西林/舒巴坦,还有四环素.此外,当与高水平庆大霉素和万古霉素联合使用时,它表现出协同作用,显示敏感性。然而,它对青霉素和呋喃的活性较差。据我们所知,这是第一个从膀胱癌患者的尿液中分离和鉴定流球菌的研究,并且系统回顾了其他报道的人的阴道球菌感染,为指导临床治疗和诊断感染的临床合理用药及相关致病机制研究提供了实验依据。同时,我们已经系统地审查了其他报告。
Vagococcus fluvialis infection is
rare in humans, and there is limited research on the clinical manifestations and antimicrobial susceptibility testing of Vagococcus fluvialis infection. Here, We isolated Vagococcus fluvialis from the urine samples of bladder cancer patients at Hunan Provincial People\'s Hospital, and it is the first reported case of Vagococcus fluvialis isolated from the urine. The fully automated microbial identification system and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) identified the bacterium as Vagococcus fluvialis with a confidence level of 99.9%. The VITEK-2Compact fully automated microbial susceptibility analysis system indicated that it was most sensitive to tigecycline, vancomycin, quinupristin/dalfopristin, linezolid, and showed moderate sensitivity to erythromycin, levofloxacin, ciprofloxacin, ampicillin/sulbactam, and tetracycline. Additionally, it exhibited synergy when combined with high-level gentamicin and vancomycin, showing sensitivity. However, it displayed poor activity against penicillin and furanth. According to our knowledge, this is the first study to isolate and identify Vagococcus fluvialis from the urine of bladder cancer patients and the systematically reviewed other reported Vagococcus infections on human, which provide an experimental basis for guiding the rational use of drugs in the clinical treatment and diagnose of Vagococcus fluvialis infection and related pathogenic mechanism research. Meanwhile, we have systematically reviewed other reported.