%0 Case Reports %T Porokeratosis of the scrotum: a case report and literature review. %A Zhang X %A Chen B %A Yang J %J Front Med (Lausanne) %V 10 %N 0 %D 2023 %M 38259830 %F 5.058 %R 10.3389/fmed.2023.1274635 %X Porokeratosis, a keratinizing disorder of unknown etiology, exhibits an autosomal dominant inheritance pattern or manifests as an isolated acquired dermatosis. This condition can occur at any site on the skin; however, scrotal lesions are extremely rare. Only 18 cases of scrotal lesions were identified through a comprehensive review of the relevant literature. Herein, we present a case of a 19-year-old patient with porokeratosis of the scrotum. Additionally, we provide a summary of the etiologies, clinical manifestations, and histopathology of scrotal porokeratosis, and present differential diagnoses by reviewing the related literature.