{Reference Type}: Case Reports {Title}: Porokeratosis of the scrotum: a case report and literature review. {Author}: Zhang X;Chen B;Yang J; {Journal}: Front Med (Lausanne) {Volume}: 10 {Issue}: 0 {Year}: 2023 {Factor}: 5.058 {DOI}: 10.3389/fmed.2023.1274635 {Abstract}: Porokeratosis, a keratinizing disorder of unknown etiology, exhibits an autosomal dominant inheritance pattern or manifests as an isolated acquired dermatosis. This condition can occur at any site on the skin; however, scrotal lesions are extremely rare. Only 18 cases of scrotal lesions were identified through a comprehensive review of the relevant literature. Herein, we present a case of a 19-year-old patient with porokeratosis of the scrotum. Additionally, we provide a summary of the etiologies, clinical manifestations, and histopathology of scrotal porokeratosis, and present differential diagnoses by reviewing the related literature.