背景:儿童时期的睡眠呼吸障碍(SDB)很常见,包括从原发性打鼾(PS)到阻塞性睡眠呼吸暂停综合征(OSAS)的一系列呼吸异常。研究表明,不仅OSAS,还有PS,最初被认为是无害的,可能会导致心血管疾病,认知,行为,和心理社会问题。许多研究集中在OSA与血脂水平的关系上。然而,很少有研究关注儿童PS和血脂水平。我们评估了血清脂质(总胆固醇(TC),甘油三酯(TG),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C))浓度与SDB的特定成分有关,包括氧还原指数,最低氧饱和度,平均氧饱和度。我们探讨了血脂水平是否与不同程度的睡眠障碍(PS和OSA组)和肥胖有关。
方法:这是一项横断面研究。在SDB组中收集了监护人抱怨习惯性打鼾和(或)口呼吸的儿童。对照组与没有睡眠问题的正常儿童相匹配。SDB组的受试者接受多导睡眠图。所有儿童的血脂谱包括TC,TG,通过适当的酶测定法测量HDL-C和LDL-C浓度。
结果:共有241例呼吸暂停/呼吸不足指数≥5(AHI)被分配到OSAS组,其余155例AHI正常被分配到PS组。TC的值,TG,OSAS组LDL-C和LDL/HDL显著高于PS组,PS组的数值明显高于对照组。多元回归分析显示血清TG仅与最低血氧饱和度呈负相关。在所有1310名儿童(P=0.031)和SDB396名儿童(P=0.012)中,体重指数-z评分对TG均有积极影响。肥胖组血清TG水平明显高于非肥胖组。
结论:SDB对血脂有非常明显的影响,而PS无呼吸暂停和缺氧。肥胖仅影响TG的聚集。
背景:ChiCTR1900026807(2019.10.23)。
BACKGROUND: Sleep-disordered breathing (SDB) during childhood is common and includes a range of breathing abnormalities that range from primary snoring (PS) to obstructive sleep apnea syndrome (OSAS).Studies have shown that not only OSAS, but also PS, which is originally considered harmless, could cause cardiovascular, cognitive, behavioral, and psychosocial problems. Many researches are focused on the relation of OSA and serum lipid levels. However, little studies are focused on PS and serum lipid levels in children.We evaluated whether serum lipid (total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C)) concentrations were associated with specific components of SDB, including indices of oxygen reduction index, lowest oxygen saturation, mean oxygen saturation. And we explored whether serum lipid levels were associated with different degree sleep disordered (PS and OSA group) and obese.
METHODS: This was a cross-sectional study. Children who were complained by their guardians with habitual snoring and(or) mouth breathing were collected in the SDB group. Normal children without sleep problem were matched in the control group. Subjects in the SDB group underwent polysomnography. The serum lipid profiles of all the children included TC, TG, HDL-C and LDL-C concentrations were measured by appropriate enzymatic assays.
RESULTS: A total of 241 with Apnea/Hypopnea Index ≥ 5 (AHI) were assigned to the OSAS group and the remaining 155 with normal AHI were assigned to the PS group. The values of TC, TG, LDL-C and LDL/HDL were significantly higher in the OSAS group than in the PS group, and the values in the PS group were significantly higher than the control group. Multiple regression analysis revealed serum TG only correlated negatively with lowest oxygen saturation. Body mass index-z score has a positive effect on TG in all the 1310 children (P = 0.031) and in SDB 396 children(P = 0.012). The level of serum TG in obese group was significantly higher than that in non-obese group.
CONCLUSIONS: SDB had a very obvious effect on blood lipids, whereas PS without apnea and hypoxia. Obese only affects the aggregation of TG.
BACKGROUND: ChiCTR1900026807(2019.10.23).