Platelet indices

血小板指数
  • 文章类型: Journal Article
    血小板在免疫和炎症的先天和适应性过程中起着重要作用。炎症性肠病(IBD)是一种自身免疫性疾病,被广泛认为是由遗传易感性的组合引起的,异常的免疫反应,等。
    为了检查基因确定的血小板指数与IBD之间的关系,我们进行了孟德尔随机化(MR)研究.与血小板计数(PLT)相关的数据,平均血小板体积(MPV),血小板分布宽度(PDW),plateletcrit(PCT)来自英国生物银行。结果数据,包括IBD,克罗恩病(CD),溃疡性结肠炎(UC),来自FinnGen数据库。逆方差加权(IVW),MR-Egger,加权中位数方法用于MR分析.
    来自IVW方法的MR估计显示PLT和IBD之间的重要联系。同样,PCT和IBD遵循IVW和MR-Egger方法。虽然PLT和PCT与CD有很强的关系,根据这三种方法的研究结果。然而,PDW是UC的唯一相关指标。唯一显著的结果是IVW。
    我们的发现表明,血小板指标的波动在IBD的发展中具有重要意义。PLT和PCT与IBD和CD密切相关,分别;PDW仅与UC连接。血小板在IBD的进展中起重要作用(UC,CD)。
    UNASSIGNED: Platelets play a significant role in the innate and adaptive processes of immunity and inflammation. Inflammatory bowel disease (IBD) is an autoimmune disease that is widely understood to be caused by a combination of genetic predisposition, aberrant immune responses, etc.
    UNASSIGNED: To examine the relationships between genetically determined platelet indices and IBD, we conducted a Mendelian randomization (MR) study. Data associated with platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) were used from the UK Biobank. The outcome data, including IBD, Crohn\'s disease (CD), ulcerative colitis (UC), were from the FinnGen database. The inverse variance-weighted (IVW), MR-Egger, weighted median methods were used for MR analyses.
    UNASSIGNED: The MR estimations from the IVW approach show a significant connection between PLT and IBD. Similarly, PCT and IBD have a relationship following the IVW and MR-Egger approaches. While PLT and PCT have strong relationships with CD, according to the findings of all three approaches respectively. Nevertheless, PDW was the only relevant indicator of UC. The only significant result was IVW\'s.
    UNASSIGNED: Our findings suggest that the fluctuation of platelet indicators is of great significance in the development of IBD. PLT and PCT have a close association with IBD and CD, respectively; PDW only has a connection with UC. Platelets play an important role in the progression of IBD (UC, CD).
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  • 文章类型: Journal Article
    以前的工作表明,血液系统可能会受到铅接触的影响;然而,在金属污染地区的人群中,多种金属对血小板的影响仍然难以捉摸。因此,这项研究招募了609名参与者,396来自金属暴露区域,213来自控制区域。血小板计数(PLT),平均血小板体积(MPV),血小板增多症(PCT),血小板与大细胞比率(P-LCR),选择血小板分布宽度(PDW)评价血小板功能。逐步回归和Lasso回归用于确定最有影响力的金属。此外,广义线性模型(GLM),贝叶斯核机回归(BKMR)模型,和分位数g计算用于评估12种尿金属和血小板指数之间的个体或综合效应关联。结果显示除了钒以外的所有金属,铜,锶,和钼在暴露组中明显更高。GLM模型表明尿金属,包括铅,锑,还有砷,展示了与PLT的关联,MPV,P-LCR,和PDW。分位数g计算和BKMR证明了金属混合物与MPV以及PDW之间的负相关。总之,该研究强调了多种金属暴露与血小板指数之间的关联,这表明金属混合物水平升高可能会阻碍金属污染地区人群的血小板活化。
    Previous works have shown that hematological system can be affected by exposure to lead; however, the effects of multiple metals on platelets remain elusive within the population from metal-contaminated areas. Hence, the study enrolled 609 participants, with 396 from a metal-exposed area and 213 from a control area. Platelet count (PLT), mean platelet volume (MPV), thrombocytocrit (PCT), platelet to large cell ratio (P-LCR), and platelet distribution width (PDW) were selected to evaluate platelet function. Stepwise regression and Lasso regression were utilized to identify the most influential metals. Moreover, the generalized linear model (GLM), Bayesian kernel machine regression (BKMR) models, and quantile g-computation were employed to estimate the individual or combined effects associations between 12 urinary metals and platelet indices. The results revealed all metals except vanadium, copper, strontium, and molybdenum were significantly higher in the exposed group. The GLM models indicated that urinary metals, including lead, antimony, and arsenic, exhibited associations with PLT, MPV, P-LCR, and PDW. Quantile g-computation and BKMR demonstrated negative correlations between metal mixtures and MPV as well as PDW. In conclusion, the study highlights the associations between multiple metal exposures and platelet indices, suggesting that elevated levels of the metal mixture may impede platelet activation in the population in metal-contaminated areas.
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  • 文章类型: Journal Article
    血小板指数(PI)是指示数字的血液学参数,形态学,和血小板的活化。尽管一些临床试验表明PI与卒中风险之间存在关联,缺乏确凿的证据归因于混杂效应和反向因果关系.
    本研究旨在通过孟德尔随机化(MR)评估PI与卒中风险之间的关联,同时探索血压在这种关联中的中介作用。
    我们确定了与PI相关的遗传变异,包括血小板计数(PLT),血小板分布宽度(PDW),平均血小板体积(MPV),和血小板暴动(PCT),在英国生物库(n=350,474)。利用相关的全基因组关联研究来收集与感兴趣的性状有关的汇总统计数据。我们主要使用逆方差加权分析来获得个体因果力的估计。
    我们观察到基因预测的PCT水平增加与卒中发作之间呈正相关[PCT:OR(95CI)=1.113(1.047,1.183),p<0.001]。然而,PLT之间没有发现显著的因果关系,PDW,MPV和卒中风险[PLT:OR(95CI)=1.037(0.979,1.098),p=0.221;PDW:OR(95CI)=0.973(0.923,1.024),p=0.294;MPV:OR(95CI)=0.990(0.945,1.038),p=0.675]。多变量MR分析和中介分析发现,收缩压(SBP)介导的比例为23.71%[95CI(10.85-33.31%)],舒张压(DBP)介导的比例为28.09%[95CI(12.92-39.63%)]。
    这项大型MR研究提供了PCT水平与缺血性卒中风险之间潜在因果关系的证据。这可能是由血压介导的。
    UNASSIGNED: Platelet indices (PIs) are hematological parameters that indicate the number, morphology, and activation of platelets. Although some clinical trials suggest an association between PIs and the risk of stroke, the lack of robust evidence is attributed to confounding effects and reverse causation.
    UNASSIGNED: This study aimed to evaluate the association between PIs and stroke risk through Mendelian randomization (MR) while exploring the mediating effect of blood pressure in this association.
    UNASSIGNED: We identified genetic variants associated with PIs, including platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), and platelet crit (PCT), in the UK Biobank (n = 350,474). Relevant genome-wide association studies were utilized to gather summary statistics pertaining to the traits of interest. We primarily used the inverse-variance weighted analysis to obtain estimates for individual causal power.
    UNASSIGNED: We observed a positive correlation between genetically predicted increases in PCT levels with the stroke onset [PCT: OR (95%CI) = 1.113(1.047, 1.183), p < 0.001]. However, no significant causal relationship was found between PLT, PDW, and MPV and the risk of stroke [PLT: OR (95%CI) = 1.037(0.979, 1.098), p = 0.221; PDW: OR (95%CI) = 0.973(0.923, 1.024), p = 0.294; MPV: OR (95%CI) = 0.990(0.945, 1.038), p = 0.675]. Multivariable MR analyses and mediation analysis found that the proportion mediated by systolic blood pressure (SBP) is 23.71% [95%CI (10.85-33.31%)] and the proportion mediated by diastolic blood pressure (DBP) is 28.09% [95%CI (12.92-39.63%)].
    UNASSIGNED: This large MR study presents evidence for the potential causal relationship between the PCT level and the risk of ischemic stroke, which might be mediated by blood pressure.
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  • 文章类型: Journal Article
    背景:血小板指数是反映血小板活化的基于血液的参数。先前的研究已经确定了血小板指数与血压(BP)之间的关联。然而,因果推断容易因混淆效应和反向因果关系而产生偏差。我们进行了孟德尔随机化(MR)研究,以比较遗传确定的血小板指数和BP水平之间的因果关系。
    方法:与血小板计数(PLT)相关的单核苷酸多态性(SNP),plateletcrit(PCT),平均血小板体积(MPV),血小板分布宽度(PDW),在英国生物库的全基因组显著性水平(p<5×10-8)和BP被用作工具变量。在双向单变量MR分析中,逆方差加权(IVW),埃格先生,和加权中位数方法用于获得个体因果力的估计。此外,我们进行了异质性和敏感性分析,以检查效应估计值的多效性.最后,进行了多变量MR分析,以弄清四种血小板指数对BP的比较影响。
    结果:在单变量MR分析中,PLT和PCT水平升高与较高的BP相关,仅PDW与较高的DBP相关。在相反的方向,SBP对PLT和PCT影响较小。在多变量MR分析中,PDW和PLT显示出独立的效应,而共线校正后PCT和MPV的关联不显著。
    结论:这些发现提示血小板和血压可能相互影响。PDW和PLT是影响BP的独立血小板指标。血小板活化和聚集增加可能与高血压的发病机制有关。这可能为评估高BP患者的血栓栓塞事件提供见解。在高血压人群中开始抗血小板治疗的必要性需要进一步研究。
    BACKGROUND: Platelet indices are blood-based parameters reflecting the activation of platelets. Previous studies have identified an association between platelet indices and blood pressure (BP). However, causal inferences are prone to bias by confounding effects and reverse causation. We performed a Mendelian randomization (MR) study to compare the causal roles between genetically determined platelet indices and BP levels.
    METHODS: Single-nucleotide polymorphisms (SNPs) associated with platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV), platelet distribution width (PDW), and BP at the level of genome-wide significance (p < 5 × 10- 8) in the UK Biobank were used as instrumental variables. In bidirectional univariable MR analyses, inverse variance-weighted (IVW), MR‒Egger, and weighted median methods were used to obtain estimates for individual causal power. In addition, heterogeneity and sensitivity analyses were performed to examine the pleiotropy of effect estimates. Finally, multivariable MR analyses were undertaken to disentangle the comparative effects of four platelet indices on BP.
    RESULTS: In the univariable MR analyses, increased levels of PLT and PCT were associated with higher BP, and PDW was associated with higher DBP alone. In the reverse direction, SBP had a minor influence on PLT and PCT. In multivariable MR analysis, PDW and PLT revealed an independent effect, whereas the association for PCT and MPV was insignificant after colinear correction.
    CONCLUSIONS: These findings suggest that platelets and BP may affect each other. PDW and PLT are independent platelet indices influencing BP. Increased platelet activation and aggregation may be involved in the pathogenesis of hypertension, which may provide insights into evaluating thromboembolic events in people with high BP. The necessity of initiating antiplatelet therapy among hypertension groups needs further investigation.
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  • 文章类型: Journal Article
    背景:妊娠相关病理并发症(PPCs)增加产后出血(PPH)的风险,血小板活化和破坏是PPC的预期结果。本研究旨在比较非妊娠(NP)育龄妇女的血小板指数,健康孕妇(HP),和有PPC的女性,并研究这些指标在PPH预测中的应用。
    方法:这项回顾性临床研究包括260名NP育龄妇女和119名孕妇。在119名怀孕的病人中,69人患有HP,50人患有PPC。Further,50例患者给予PPH。我们比较了血小板计数(PC),平均血小板体积(MPV),血小板分布宽度(PDW),plateletcrits(Pcts),MPV比率(PC/MPV和Pct/MPV),α角(角度),使用SysmexXN10血液分析仪和TEG5000止血分析仪系统,分别。
    结果:除了PDW,NP的血小板参数存在显著差异,HP,和PPC患者(P<0.05)。组间比较结果显示,NP患者与HP和PPC患者在年龄方面存在显著差异,MA,PC,Pct,Pct/MPV(P<0.0125)。Further,HP和PPC患者在Pct方面存在显着差异,MPV,PC/MPV,Pct/MPV(P<0.0125)。此外,单因素分析表明,在PPC患者中,低MPV值与PPH强相关[比值比(OR)=0.012,P=0.003;OR=0.331,P=0.047].
    结论:患有PPC的女性PC明显降低,Pct,PC/MPV和Pct/MPV值,但显著高于MA和MPV值。PPHs与PPC和低MPV值密切相关。及时准确的诊断和评估MPV值可能有助于预测PPH。
    BACKGROUND: Pregnancy-related pathological complications (PPCs) increase the risk of postpartum hemorrhage (PPH), Platelet activation and destruction are expected outcomes of PPCs. This study sought to compare the platelet indices of non-pregnant (NP) child-bearing aged women, healthy pregnant (HP) women, and women with PPCs, and investigate the use of these indices in PPH prediction.
    METHODS: This retrospective clinical study included 260 NP child-bearing aged women and 119 pregnant women. Of the 119 pregnant patients, 69 had HPs and 50 suffered from PPCs. Further, 50 patients delivered with PPH. We compared the platelet counts (PCs), mean platelet volumes (MPVs), platelet distribution widths (PDWs), plateletcrits (Pcts), MPV ratios (PC/MPV and Pct/MPV), alpha angles (angles), and maximum amplitudes (MAs) of the patients using Sysmex XN10 hematology analyzer and TEG 5000 Hemostasis analyzer system, respectively.
    RESULTS: With the exception of PDW, there were significant differences in the platelet parameters of the NP, HP, and PPC patients (P<0.05). The intergroup comparison results showed that the NP patients differed significantly from the HP and PPC patients in terms of age, MA, PC, Pct, and Pct/MPV (P<0.0125). Further, the HP and PPC patients differed significantly in terms of Pct, MPV, PC/MPV, and Pct/MPV (P<0.0125). Additionally, the univariate analysis showed that in the PPC patients, low MPV values were strongly related to PPH [odds ratio (OR) =0.012, P=0.003; OR =0.331, P=0.047].
    CONCLUSIONS: Women with PPCs had significantly lower PC, Pct, PC/MPV and Pct/MPV values, but significantly higher MA and MPV values. PPHs were strongly related to PPC and low MPV values. A timely accurate diagnosis and evaluating MPV values may be useful in the prediction of PPH.
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  • 文章类型: Journal Article
    背景:已经评估了血小板指数在各种感染性疾病中的诊断价值,但未在感染性骨不连中进行评估。这项研究的目的是评估开放复位和内固定后血小板指数对诊断感染性骨不连的有用性。
    方法:这项回顾性研究是在2016年1月至2021年12月接受原发性骨折不愈合翻修手术的患者中进行的。共有297例患者被纳入研究:96例感染性骨不连(A组)和201例无菌骨不连(B组)。采用受试者工作特征(ROC)曲线分析评价各指标的诊断价值。曲线下面积(AUC),灵敏度,特异性,并计算和比较阳性和阴性预测值。
    结果:两组人口统计学特征具有可比性。白细胞(WBC)计数,C反应蛋白(CRP),红细胞沉降率(ESR),血浆纤维蛋白原,血浆D-二聚体,血小板计数(PC),Plateletcrit,血小板计数与平均血小板体积的比值(PC/MPV)明显较高,MPV和血小板分布宽度(PDW)显著降低,A组优于B组(P<0.05)。ROC分析显示PC/MPV和血浆纤维蛋白原比其他凝血指标具有更好的诊断价值(AUC分别为0.801和0.807)。ESR的组合,血浆纤维蛋白原,PC/MPV对感染性骨不连的诊断具有良好的敏感性和特异性。PC/MPV在凝血相关合并症患者亚组中的诊断价值优于ESR和血浆纤维蛋白原。
    结论:血浆纤维蛋白原和PC/MPV比值可能是感染性骨不连早期诊断的有用参数。
    BACKGROUND: The diagnostic value of platelet indices has been evaluated in various infectious diseases but not in infected nonunion. The purpose of this study was to assess the usefulness of platelet indices for diagnosis of infected nonunion after open reduction and internal fixation.
    METHODS: This retrospective study was performed in patients who underwent primary fracture nonunion revision surgeries from January 2016 to December 2021. A total of 297 patients were included in the study: 96 with infected nonunion (group A) and 201 with aseptic nonunion (group B). Receiver operator characteristic (ROC) curve analysis was performed to evaluate diagnostic value of each index. Area under the curve (AUC), sensitivity, specificity, and positive and negative predictive values were calculated and compared.
    RESULTS: Demographic characteristics were comparable between the two groups. White blood cell (WBC) count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), plasma fibrinogen, plasma D-dimer, platelet count (PC), plateletcrit, and ratio of platelet count to mean platelet volume (PC/MPV) were significantly higher, and MPV and platelet distribution width (PDW) significantly lower, in group A than in group B (P < 0.05). ROC analysis showed PC/MPV and plasma fibrinogen to have better diagnostic value than the other coagulation indicators (AUC of 0.801 and 0.807, respectively). The combination of ESR, plasma fibrinogen, and PC/MPV had good sensitivity and specificity for diagnosis of infected nonunion. PC/MPV had better diagnostic value than ESR and plasma fibrinogen in the subgroup of patients with coagulation-related comorbidities.
    CONCLUSIONS: Plasma fibrinogen and PC/MPV ratio might be useful parameters for early diagnosis of infected nonunion.
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  • 文章类型: Journal Article
    目的:揭示梅毒患者血小板指标的作用。
    方法:本回顾性队列研究共纳入2061例梅毒患者和528例健康对照。血小板计数(PLT)数据,平均血小板体积(MPV),血小板分布宽度(PDW),收集梅毒活动指标。分析血小板指标与疾病活动的相关性。
    结果:2061例患者中共425例(20.6%)为原发性和继发性梅毒,433(21.0%)潜伏,463(22.5%)血清,350(17.0%)无症状神经梅毒,有症状的神经梅毒390例(18.9%)。与健康对照组相比,原发性和继发性梅毒组的PLT显着增加;然而,梅毒各阶段MPV和PDW均显著降低。抗螺旋体治疗后,血小板指数的这些变化被逆转。进一步的相关性分析显示,PLT与梅毒活性指标[快速血浆反应素(RPR)滴度呈正相关,脑脊液白细胞(CSF-WBC),CSF-蛋白,和CSF-VDRL(性病研究实验室)]和炎症标志物[WBC,C反应蛋白(CRP),和红细胞沉降率(ESR)]。相反,PDW与所有这些参数呈负相关。MPV与RPR呈反比关系,ESR,CRP。
    结论:血小板指数与梅毒活动相关。
    OBJECTIVE: To uncover the role of the platelet indices in patients with syphilis.
    METHODS: A total of 2061 patients with syphilis and 528 healthy controls were enrolled in this retrospective cohort study. The data of platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and indicators of syphilis activities were collected. The correlations between the platelet indices and disease activities were analyzed.
    RESULTS: A total of 425 (20.6%) of the 2061 patients were of primary and secondary syphilis, 433 (21.0%) latent, 463 (22.5%) serofast, 350 (17.0%) asymptomatic neurosyphilis, and 390 (18.9%) symptomatic neurosyphilis. Compared with the healthy controls, PLT was significantly increased in the primary and secondary syphilis group; whereas, MPV and PDW were significantly decreased in all stages of syphilis. These changes of platelet indices were reversed after anti-treponemal therapy. Further correlation analysis showed that PLT was positively associated with the syphilis activity indicators [rapid plasma reagin (RPR) titer, cerebrospinal fluid white blood cell (CSF-WBC), CSF-protein, and CSF-VDRL (venereal disease research laboratory)] and inflammatory markers [WBC, C-reaction protein (CRP), and erythrocyte sedimentation rate (ESR)]. Conversely, PDW was negatively correlated with all of these parameters. MPV had an inverse relationship with RPR, ESR, and CRP.
    CONCLUSIONS: Platelet indices are associated with syphilis activities.
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  • 文章类型: Journal Article
    BACKGROUND: The aim of the study was to investigate the baseline characters that influence 3-month clinical outcomes in patients with acute ischemic stroke (AIS) after thrombolytic therapy.
    METHODS: We consecutively enrolled 241 AIS patients who are treated with thrombolytic therapy with recombinant tissue plasminogen activator. Baseline characters were measured on admission including the National Institutes of Health Stroke Scale (NIHSS), Trial of Org 10172 in Acute Stroke Treatment (TOAST), risk factors, platelet indices, and lipid parameters. The subjects were divided into good or poor functional outcomes based on modified Rankin Scale at 3 months. The multivariate logistic regression was performed to explore the association between baseline factors and outcomes. Pearson correlation was used to investigate whether linear associations existed between platelet indices in different outcomes.
    RESULTS: Multivariate logistic regression analysis showed that the NIHSS, TOAST classification, diabetes, mean platelet volume (MPV) are important factors for predicting clinical outcomes after 3 months in AIS patients. We found a correlation between elevated MPV and worse outcome at 3 months, particularly in large-artery atherosclerosis stroke patients. MPV and platelet count are negative correlated (r = -0.375, p = 0.000). MPV and platelet-to-lymphocyte ratio (PLR) (r = 0.83, p = 0.000), MPV and platelet distribution width (PDW) (r = 0.820, p = 0.000) both have highly positive linear correlations in patients with good outcome.
    CONCLUSIONS: Overall, lower NIHSS and MPV levels on admission were predictors of good functional outcomes in patients with AIS after undergoing thrombolytic therapy. The correlations between MPV, PDW, and PLR may be helpful to evaluate prognosis in stroke patients and deserve further exploration.
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  • 文章类型: Journal Article
    OBJECTIVE: Platelet activation is a possible pathogenic process contributing to thromboembolism in antiphospholipid syndrome (APS), and platelet distribution width (PDW) is associated with platelet activation. The objective of this study was to evaluate the association between platelet indices and thrombotic events in patients with primary APS.
    METHODS: This single-center cross-sectional study included 207 consecutive patients with APS treated at our institution between 2010 and 2019. Results of blood tests were recorded retrospectively from medical records.
    RESULTS: Of the included patients, 135 (65.2%) were female and 72 (34.8%) were male. They were classified into thrombotic (n = 150) or non-thrombotic (n = 57) groups. PDW, mean platelet volume, and large platelet ratio were significantly higher in the thrombotic group. In univariate logistic analysis, PDW was significantly associated with an increased odds of thrombosis [odds ratio (OR) 1.554, 95% confidence interval (CI) 1.289-1.873, p<0.001]. In multivariate logistic analysis, PDW and positive lupus anticoagulant (LA) were risk factors for thrombosis. Receiver operating characteristic analysis showed that PDW, combined with a positive LA, was a reliable indicator of thrombosis, with an area under the curve of 0.796 (95% CI 0.728-0.864). The optimal cutoff value for PDW was 12.4 fl, with a sensitivity of 72.0% and specificity of 77.2%. Multivariate logistic regression of PDW tertiles showed that the odds of thrombosis increased abruptly in the highest tertile.
    CONCLUSIONS: This study confirmed the association between PDW and thrombotic events in APS patients, supporting the theory that platelet activation is a crucial mechanism of thrombosis in APS. Key Points • This study is the first to discuss the correlation between PDW and thromboses in patients with APS. • This study provides evidence of the important role of platelet activation in the pathogenesis of APS.
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  • 文章类型: Journal Article
    目的:糖尿病被认为是血小板反应性增强的“血栓前状态”。在最常见的慢性并发症-糖尿病周围神经病变(DPN)的患者中发现了血小板聚集异常。目的探讨中国2型糖尿病患者血小板指标与神经传导功能及DPN存在的潜在关联。
    方法:本研究共纳入了211名2型糖尿病住院患者和55名健康个体,对其进行了神经传导研究。根据美国糖尿病协会的建议诊断DPN。回顾性收集临床资料。
    结果:发生神经病变的糖尿病患者的血小板计数(PLT)和血小板计数(PCT)水平低于健康对照组(P<0.05)。低PLT和PCT水平与总振幅/速度Z评分降低的统计学显著关联,在神经传导研究中发现了F波最小潜伏期的延长。此外,经过多变量调整后,Logistic回归分析显示,2型糖尿病患者PLT水平较低(比值比2.268,95%置信区间1.072-4.797;P<0.05;PLT<226vsPLT≥226)和PCT(比值比2.050,95%置信区间1.001-4.201;P<0.05;PCT<0.222vsPCT≥0.222)是DPN存在的危险因素。
    结论:较低的PLT和PCT水平与2型糖尿病患者周围神经传导功能较差和存在神经病变密切相关,这表明PLT和PCT可能是显示DPN的潜在生物标志物。
    OBJECTIVE: Diabetes has been considered as a \'pro-thrombotic state\' with enhanced platelet reactivity. Abnormality in platelet aggregation has been found in patients with its most common chronic complication - diabetic peripheral neuropathy (DPN). The purpose of this study was to investigate the potential association of platelet indices with nerve conduction function and the presence of DPN in Chinese patients with type 2 diabetes mellitus.
    METHODS: This study involved a total of 211 inpatients with type 2 diabetes mellitus and 55 healthy individuals for whom nerve conduction studies were carried out. DPN was diagnosed according to the American Diabetes Association recommendation. Clinical data were retrospectively collected.
    RESULTS: Patients with diabetes in whom neuropathy developed had lower levels of platelet count (PLT) and plateletcrit (PCT) than healthy controls (P < 0.05). Statistically significant associations of low PLT and PCT levels with the reduction of summed amplitude/velocity Z-score, and the prolongation of F-wave minimum latency in nerve conduction studies were found. Furthermore, after multivariate adjustment, logistic regression analysis showed that low levels of PLT (odds ratio 2.268, 95% confidence interval 1.072-4.797; P < 0.05; PLT <226 vs PLT ≥226) and PCT (odds ratio 2.050, 95% confidence interval 1.001-4.201; P < 0.05; PCT <0.222 vs PCT ≥0.222) in type 2 diabetes mellitus patients were risk factors for the presence of DPN.
    CONCLUSIONS: Lower PLT and PCT levels are closely associated with poorer peripheral nerve conduction functions and the presence of neuropathy in patients with type 2 diabetes mellitus, which suggests that PLT and PCT might be potential biomarkers for showing DPN.
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