背景:妊娠相关病理并发症(PPCs)增加产后出血(PPH)的风险,血小板活化和破坏是PPC的预期结果。本研究旨在比较非妊娠(NP)育龄妇女的血小板指数,健康孕妇(HP),和有PPC的女性,并研究这些指标在PPH预测中的应用。
方法:这项回顾性临床研究包括260名NP育龄妇女和119名孕妇。在119名怀孕的病人中,69人患有HP,50人患有PPC。Further,50例患者给予PPH。我们比较了血小板计数(PC),平均血小板体积(MPV),血小板分布宽度(PDW),plateletcrits(Pcts),MPV比率(PC/MPV和Pct/MPV),α角(角度),使用SysmexXN10血液分析仪和TEG5000止血分析仪系统,分别。
结果:除了PDW,NP的血小板参数存在显著差异,HP,和PPC患者(P<0.05)。组间比较结果显示,NP患者与HP和PPC患者在年龄方面存在显著差异,MA,PC,Pct,Pct/MPV(P<0.0125)。Further,HP和PPC患者在Pct方面存在显着差异,MPV,PC/MPV,Pct/MPV(P<0.0125)。此外,单因素分析表明,在PPC患者中,低MPV值与PPH强相关[比值比(OR)=0.012,P=0.003;OR=0.331,P=0.047].
结论:患有PPC的女性PC明显降低,Pct,PC/MPV和Pct/MPV值,但显著高于MA和MPV值。PPHs与PPC和低MPV值密切相关。及时准确的诊断和评估MPV值可能有助于预测PPH。
BACKGROUND: Pregnancy-related pathological complications (PPCs) increase the risk of postpartum hemorrhage (PPH), Platelet activation and destruction are expected outcomes of PPCs. This study sought to compare the platelet indices of non-pregnant (NP) child-bearing aged women, healthy pregnant (HP) women, and women with PPCs, and investigate the use of these indices in PPH prediction.
METHODS: This retrospective clinical study included 260 NP child-bearing aged women and 119 pregnant women. Of the 119 pregnant patients, 69 had HPs and 50 suffered from PPCs. Further, 50 patients delivered with PPH. We compared the platelet counts (PCs), mean platelet volumes (MPVs), platelet distribution widths (PDWs), plateletcrits (Pcts), MPV ratios (PC/MPV and Pct/MPV), alpha angles (angles), and maximum amplitudes (MAs) of the patients using Sysmex XN10 hematology analyzer and TEG 5000 Hemostasis analyzer system, respectively.
RESULTS: With the exception of PDW, there were significant differences in the platelet parameters of the NP, HP, and PPC patients (P<0.05). The intergroup comparison results showed that the NP patients differed significantly from the HP and PPC patients in terms of age, MA, PC, Pct, and Pct/MPV (P<0.0125). Further, the HP and PPC patients differed significantly in terms of Pct, MPV, PC/MPV, and Pct/MPV (P<0.0125). Additionally, the univariate analysis showed that in the PPC patients, low MPV values were strongly related to PPH [odds ratio (OR) =0.012, P=0.003; OR =0.331, P=0.047].
CONCLUSIONS: Women with PPCs had significantly lower PC, Pct, PC/MPV and Pct/MPV values, but significantly higher MA and MPV values. PPHs were strongly related to PPC and low MPV values. A timely accurate diagnosis and evaluating MPV values may be useful in the prediction of PPH.