未经授权:肿瘤微环境在癌症进展中起着重要作用。血小板是肿瘤环境的组成部分之一,在癌症生存和进展中起作用。
UNASSIGNED:本研究考虑了96例口腔鳞状细胞癌(SCC)病例和96例年龄/性别匹配的健康对照。关于血小板计数的数据,血小板分布宽度(PDW),平均血小板体积(MPV),血小板-大细胞比值(P-LCR),Plateletcrit(PCT),血小板/中性粒细胞比率(PNR),血小板/淋巴细胞比率(PLR),和血小板/单核细胞比率(PNR)从自动血液分析仪记录和临床病理数据从病理科。这些数据在病例和对照组之间进行了比较,也与肿瘤大小进行了比较,肿瘤分级,淋巴结状态,和肿瘤淋巴结转移(TNM)分期。
未经证实:血小板计数的平均值±标准偏差,PDW,MPV,P-LCR,PCT,PNR,病例的PLR和PMR分别为315.03±98.26、10.94±1.66、9.91±0.77、23.52±5.64、0.31±0.086、62.55±31.51、149.34±61.32和498.67±194.91。对照组分别为287.88±74.11、10.84±1.18、9.89±0.72、23.45±4.55、0.29±0.061、60.27±21.02、138.71±49.28和497.64±172.28。血小板计数手段之间的关联,PDW,P-LCR,病例和对照组之间的PCT差异有统计学意义(P分别为0.020、0.006、0.030和0.000)。在血小板计数的平均值之间没有发现统计学上的显著关联,PDW,MPV,P-LCR,PCT,PNR,PLR,和PMR与肿瘤大小的关系,淋巴结状态,和肿瘤等级。PCT/PMR与TNMI期和II期之间的相关性具有统计学意义(分别为P=0.029和0.016)。
未经证实:血小板计数,形态学,口服SCC功能改变。血小板活化在口腔癌中起重要作用。PCT和PMR可作为经济有效的炎症标志物用于预测口服SCC的进展。
UNASSIGNED: Tumor microenvironment plays an important role in cancer progression. Platelets are one of the components of the tumor environment shown to have a role in cancer survival and progression.
UNASSIGNED: Ninety-six cases of squamous cell carcinoma (SCC) cases of the oral cavity and 96 age/sex-matched healthy controls were considered for the study. Data regarding platelet count, platelet distribution width (PDW), mean platelet volume (MPV), Platelet-Large Cell Ratio (P-LCR), Plateletcrit (PCT), platelet/neutrophil ratio (PNR), platelet/lymphocyte ratio (PLR), and Platelet/Monocyte Ratio (PNR) from automated hematology analyzer records and clinicopathological data from the Department of Pathology were captured. These data were compared between cases and controls and also with tumor size, tumor grade, lymph node status, and tumour node metastasis (TNM) stage of cases.
UNASSIGNED: Mean ± standard deviation for platelet count, PDW, MPV, P-LCR, PCT, PNR, PLR and PMR among cases were 315.03 ± 98.26, 10.94 ± 1.66, 9.91 ± 0.77, 23.52 ± 5.64, 0.31 ± 0.086, 62.55 ± 31.51, 149.34 ± 61.32, and 498.67 ± 194.91, respectively, and among controls were 287.88 ± 74.11, 10.84 ± 1.18, 9.89 ± 0.72, 23.45 ± 4.55, 0.29 ± 0.061, 60.27 ± 21.02, 138.71 ± 49.28, and 497.64 ± 172.28, respectively. The association between means of platelet count, PDW, P-LCR, and PCT among cases and controls were statistically significant (P = 0.020, 0.006, 0.030, and 0.000, respectively). No statistically significant association was found between means of platelet count, PDW, MPV, P-LCR, PCT, PNR, PLR, and PMR versus tumor size, lymph node status, and tumor grades. The association between the means of PCT/PMR and TNM Stages I and II were statistically significant (P = 0.029 and 0.016, respectively).
UNASSIGNED: Platelet count, morphology, and functions are altered in oral SCC. Platelet activation plays an important role in oral cancer. PCT and PMR can be used to predict the progress of oral SCC as a cost-effective inflammatory marker.