背景：在临床实践中，实验室检查结果对诊断和治疗具有重要意义。不同参数的参考间隔有助于医疗保健专业人员解释结果。关于印度参考区间的研究很少。这项前瞻性研究是为了确定血小板计数（PLT）和PLT指数的参考间隔；平均PLT体积（MPV），PLT分布宽度(PDW),和PLT大细胞比率(P-LCR)。这些值可以作为常规全血细胞计数（CBC）的一部分获得，并且在某些疾病中具有诊断和预后意义。PLT计数是选择重复血小板分离捐赠的供体的重要标准。
方法：这项研究招募了1600名首次健康的血小板分离志愿者。CBC完成了，PLT值，MPV,PDW,并注意到P-LCR，并对结果进行了分析。根据临床和实验室标准研究所指南，使用第2.5和97.5百分位数估计了95％的参考分布。供体不良反应,如果有的话，还研究了单供体PLT（SDP）的质量参数。
结果：PLT的参考范围值，MPV,PDW,P-LCR为137,825-355,175/μl，8.1-13.9/fl,9.1-22.5/fl,和11.7%-52.9%，分别,并与印度发表的其他研究进行了很好的比较。观察到，研究中获得的PLT计数参考值低于印度大多数实验室目前使用的参考值（150,000-450,000/μl）。
结论：根据我们的结果，我们认为，对于我国而言，重复血小板分离捐献的PLT计数截止值可能需要向下修改，这也将减轻单采捐献者的稀缺性。
BACKGROUND: In clinical practice, laboratory results are of great importance for the diagnosis and treatment. Reference intervals of different parameters aid health-care professionals in the interpretation of results. There are very few studies on reference intervals from India. This prospective study was conducted to determine the reference intervals for platelet count (PLT) and PLT indices; mean PLT volume (MPV), PLT distribution width (PDW), and PLT large cell ratio (P-LCR). These values can be obtained as a part of a routine complete blood count (CBC) and have diagnostic and prognostic significance in certain diseases. PLT count is an important criterion for the selection of donors for repeat plateletpheresis donation.
METHODS: Sixteen hundred and thirty-four first-time healthy volunteer plateletpheresis donors were enrolled for the study. CBC was done, values of PLT, MPV, PDW, and P-LCR were noted, and the results were analyzed. The 95% of the reference distribution was estimated using the 2.5th and 97.5th percentiles following Clinical and Laboratory Standards Institute
guidelines. Adverse donor reactions, if any and quality parameters of single donor PLTs (SDP) were also studied.
RESULTS: Reference range values of PLT, MPV, PDW, and P-LCR were 137,825-355,175/μl, 8.1-13.9/fl, 9.1-22.5/fl, and 11.7%-52.9%, respectively, and compared well with other published studies from India. It was observed that reference values of PLT count obtained in the study were lower than reference values that are currently used in most laboratories (150,000-450,000/μl) in India.
CONCLUSIONS: Based on our results, we are of the opinion that the PLT count cutoffs for repeat plateletpheresis donation may need to be revised downwards for our country which would also mitigate the scarcity of apheresis donors.
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