■本研究旨在探讨高强度聚焦超声(HIFU)治疗阴道上皮内瘤变(VaIN)的安全性和有效性。
■对临床,病态,以及2018年1月至2022年12月在中南大学湘雅三医院接受VaINHIFU治疗的43例患者的随访数据。讨论了HIFU治疗VaIN的初步疗效和安全性。
■对36例患者进行了分析,平均年龄50.09±12.06岁,包括24例VaINI患者和12例VaINII患者。5例有子宫切除术史(4例因宫颈病变,1由于子宫肌瘤),2例宫颈上皮内病变(CIN)锥切术。36例患者均并发人乳头瘤病毒(HPV)感染,3例患者也有I-IICIN级并接受宫颈HIFU治疗。所有患者均顺利完成HIFU治疗,平均治疗时间5.99±1.25min,处理功率为3.5W,平均总治疗剂量为1118.99±316.20J。仅经历轻微疼痛,VAS评分为3。术后有轻微的灼烧感,在大约10-20分钟内解决。经过6次随访,33例患者(91.66%)治愈,1例患者(2.77%)表现出持续性,2例患者(5.55%)出现进展,和27名患者(75%)的HPV检测阴性。在12个月的随访中,结果与6个月的结果一致。术中及随访期间无并发症发生。
■HIFU是VaIN的安全有效治疗方法。然而,这项研究的样本量很小,相对较短的随访期,缺乏对照组,需要进一步调查。
UNASSIGNED: This study aimed to investigate the safety and efficacy of High-Intensity Focused Ultrasound (HIFU) treatment for vaginal intraepithelial neoplasia(VaIN).
UNASSIGNED: Retrospective analysis was conducted on clinical, pathological, and follow-up data of 43 patients who underwent HIFU treatment for VaIN at Xiangya Third Hospital of Central South University between January 2018 and December 2022. The preliminary efficacy and safety of HIFU in treating VaIN were discussed.
UNASSIGNED: The 36 patients were analyzed, and the average age was 50.09 ± 12.06 years, including 24 patients with VaIN I and 12 patients with VaIN II. Five cases had a history of hysterectomy (4 due to cervical lesions, 1 due to hysteromyoma), and 2 cases had conization of cervical intraepithelial lesions (CIN). All 36 cases were complicated by human papillomavirus (HPV) infection, with 3 cases also having grade I-II CIN and undergoing cervical HIFU treatment. All patients successfully completed the HIFU treatment, with an average treatment time of 5.99 ± 1.25 min, treatment power of 3.5 W, and average total treatment dose of 1118.99 ± 316.20 J. Patients tolerated the treatment well, experiencing only slight pain with VAS score of 3. There was a mild postoperative burning sensation, which resolved within approximately 10-20 min. After 6 follow-up visits, 33 patients (91.66%) achieved cure, 1 patient (2.77%) showed persistence, 2 patients (5.55%) exhibited progression, and 27 patients (75%) tested negative for HPV. At 12 months of follow-up, the results were consistent with those of 6 months. No complications occurred during the procedure and the follow-up period.
UNASSIGNED: HIFU is a safe and effective treatment for VaIN. However, this study had a small sample size, a relatively short follow-up period, and lacked a control group, requiring further investigation.