Abstract：
OBJECTIVE: Dual-frequency high-intensity focused ultrasound (HIFU) thermal ablation is an exceptionally promising technique for treating tumors due to its precision and effectiveness. However, there are still a few studies on improving the accuracy and efficiency of HIFU in superficial ablation applications. This study proposes a method utilizing dual frequency switching ultrasound (DFSU) to enhance the efficiency and precision of superficial treatments.
METHODS: A dual-frequency HIFU transducer operating at 4.5 MHz and 13.7 MHz was designed, and a dual-frequency impedance matching network was designed to optimize electro-acoustic conversion efficiency. Phantom and ex vivo tests were conducted to measure and compare thermal lesion areas and temperature rises caused by single-frequency ultrasound (SFU) and DFSU.
RESULTS: In both phantom and ex vivo tests, the utilization of DFSU resulted in larger lesion areas compared to SFU. Moreover, DFSU provided improved control and versatility, enabling precise and efficient ablation.
CONCLUSIONS: DFSU exhibits the ability to generate larger ablation areas in superficial tissue compared to SFU, and DFSU allows flexible control over the ablation area and temperature rise rate. The acoustic power deposition of HIFU can be optimized to achieve precise ablation.
METHODS: A dual-frequency HIFU transducer operating at 4.5 MHz and 13.7 MHz was designed, and a dual-frequency impedance matching network was designed to optimize electro-acoustic conversion efficiency. Phantom and ex vivo tests were conducted to measure and compare thermal lesion areas and temperature rises caused by single-frequency ultrasound (SFU) and DFSU.
RESULTS: In both phantom and ex vivo tests, the utilization of DFSU resulted in larger lesion areas compared to SFU. Moreover, DFSU provided improved control and versatility, enabling precise and efficient ablation.
CONCLUSIONS: DFSU exhibits the ability to generate larger ablation areas in superficial tissue compared to SFU, and DFSU allows flexible control over the ablation area and temperature rise rate. The acoustic power deposition of HIFU can be optimized to achieve precise ablation.
摘要：
目的：双频高强度聚焦超声（HIFU）热消融由于其精确性和有效性而成为一种非常有前途的治疗肿瘤的技术。然而,在表面消融应用中，仍有一些研究提高HIFU的准确性和效率。本研究提出了一种利用双频开关超声（DFSU）来提高表面治疗的效率和精度的方法。
方法：设计了一种工作在4.5MHz和13.7MHz的双频HIFU换能器，并设计了双频阻抗匹配网络以优化电声转换效率。进行了体模和离体测试，以测量和比较单频超声（SFU）和DFSU引起的热损伤面积和温度升高。
结果：在体模和离体测试中，与SFU相比，DFSU的使用导致更大的病变面积。此外，DFSU提供了改进的控制和多功能性，实现精确和有效的消融。
结论：与SFU相比，DFSU具有在浅表组织中产生更大消融区域的能力，和DFSU允许对消融面积和温度上升速率的灵活控制。可以优化HIFU的声功率沉积以实现精确消融。
方法：设计了一种工作在4.5MHz和13.7MHz的双频HIFU换能器，并设计了双频阻抗匹配网络以优化电声转换效率。进行了体模和离体测试，以测量和比较单频超声（SFU）和DFSU引起的热损伤面积和温度升高。
结果：在体模和离体测试中，与SFU相比，DFSU的使用导致更大的病变面积。此外，DFSU提供了改进的控制和多功能性，实现精确和有效的消融。
结论：与SFU相比，DFSU具有在浅表组织中产生更大消融区域的能力，和DFSU允许对消融面积和温度上升速率的灵活控制。可以优化HIFU的声功率沉积以实现精确消融。
