S-omeprazole and R-rabeprazole are important proton pump inhibitors (PPIs) used for treating peptic disorders. They can be biosynthesized from the corresponding sulfide catalyzed by Baeyer-Villiger monooxygenases (BVMOs). During the development of BVMOs for target sulfoxide preparation, stereoselectivity and overoxidation degree are important factors considered most. In the present study, LnPAMO-Mu15 designed previously and TtPAMO from Thermothelomyces thermophilus showed high (S)- and (R)-configuration stereoselectivity respectively towards thioethers. TtPAMO was found to be capable of oxidating omeprazole sulfide (OPS) and rabeprazole sulfide (RPS) into R-omeprazole and R-rabeprazole respectively. However, the overoxidation issue existed and limited the application of TtPAMO in the biosynthesis of sulfoxides. The structural mechanisms for adverse stereoselectivity between LnPAMO-Mu15 and TtPAMO towards OPS and the overoxidation of OPS by TtPAMO were revealed, based on which, TtPAMO was rationally designed focused on the flexibility of loops near catalytic sites. The variant TtPAMO-S482Y was screened out with lowest overoxidation degree towards OPS and RPS due to the decreased flexibility of catalytic center than TtPAMO. The success in this study not only proved the rationality of the overoxidation mechanism proposed in this study but also provided hints for the development of BVMOs towards thioether substrate for corresponding sulfoxide preparation.

This study has been successfully developed the Sodium alginate/Bamboo fiber /Gelatin（SA/BF/Gel）composite conductive hydrogel with adhesive and self-healing properties. Through in-depth research, the influence of Gel content on the tensile, adhesive, self-healing properties, and conductivity of the SA/BF/Gel composite conductive hydrogel was discussed. The sensing performance and sensing mechanism of the material were also investigated, along with a preliminary exploration of its potential applications. An attempt was made to apply the SA/BF/Gel composite conductive hydrogel to 3D printing technology, establishing a connection between the rheological properties of the hydrogel and its printing structure. The addition of Gel significantly improved the flexibility of the hydrogel, with a conductivity of up to 3.12 S/m at a Gel content of 1.5 %. When employed as a sensor, the material exhibited high sensitivity (GF = 2.21) and excellent cyclic stability, rendering it suitable for a wide range of applications in real-time monitoring of bending movements of fingers and wrists, as well as dynamic contact and variations in contact forces on the hydrogel surface. The SA/BF/Gel composite conductive hydrogel has the potential to be utilized in a multitude of applications, including the development of smart wearable devices, the monitoring of individual human beings, and the integration of human beings and machines. Furthermore, the research findings associated with this hydrogel will provide a strong foundation for the advancement of materials science and the integration of smart technologies.

Anti-icing/deicing coatings with low energy consumption and superior flexibility could better fit application requirements in practical engineering. In this paper, an active-passive-integrated anti-icing/deicing coating based on carbon nanomaterials is prepared, which not only possesses various functions of electrothermal conversion, photothermal conversion, and superhydrophobicity but also shows a large deformability to accommodate curved surfaces. The coating consists of a sandwich-structured bottom part and top layer, the former of which includes a core conductive layer made of densely mixed carbon nanotubes (CNTs) and graphene and two polydimethylsiloxane (PDMS) wrapping layers, while the latter is a polymeric composite filled with TiN and SiO2 nanoparticles. Experimental studies show that, when the present coating works under an electric field alone, a 90% conversion of electric energy to thermal energy can be realized, only a 2 V voltage is enough to unfreeze the surface at minus 20 degrees within 400 s, and a slightly larger voltage of 2.5 V leads to a significant temperature increase of more than 100 °C within 200 s. Such required voltages are significantly smaller than their counterparts in existing electrothermal-based methods to achieve the same heating effects, which could be further diminished with the auxiliary action of sunlight illumination. A fast and complete deicing/defrosting can be consequently achieved with a small energy input. Furthermore, the water repellency function, electric property, and electrothermal conversion performance of the coating remain almost unchanged after either a large bending deformation or many bending cycles, thus ensuring an outstanding anti-icing/deicing effect on both flat and curved surfaces. All of the results demonstrate apparent advantages of the present coating including high efficiency, low energy consumption, all-weather adaptability, and excellent flexibility, which should be of great practical value for the freeze protection of differently shaped industrial equipment.

Prodrug nanoassemblies combine the advantages of prodrug strategies and nanotechnology have been widely utilized for delivering antitumor drugs. These prodrugs typically comprise active drug modules, response modules, and modification modules. Among them, the modification modules play a critical factor in improving the self-assembly ability of the parent drug. However, the impact of the specific structure of the modification modules on prodrug self-assembly remains elusive. In this study, two gemcitabine (GEM) prodrugs are developed using 2-octyl-1-dodecanol (OD) as flexible modification modules and cholesterol (CLS) as rigid modification modules. Interestingly, the differences in the chemical structure of modification modules significantly affect the assembly performance, drug release, cytotoxicity, tumor accumulation, and antitumor efficacy of prodrug nanoassemblies. It is noteworthy that the prodrug nanoassemblies constructed with flexible modifying chains (OD) exhibit improved stability, faster drug release, and enhanced antitumor effects. Our findings elucidate the significant impact of modification modules on the construction of prodrug nanoassemblies.

Graphite, with abundant resources and low cost, is regarded as a promising anode material for potassium-ion batteries (PIBs). However, because of the large size of potassium ions, the intercalation/deintercalation of potassium between the interlayers of graphite results in its huge volume expansion, leading to poor cycling stability and rate performance. Herein, a self-propagating reduction strategy is adopted to fabricate a flexible, self-supporting 3D porous graphite@reduced graphene oxide (3D-G@rGO) composite film for PIBs. The 3D porous network can not only effectively mitigate the volume expansion in graphite but also provide numerous active sites for potassium storage as well as allow for electrolyte penetration and rapid ion migration. Therefore, compared to the pristine graphite anode, the flexible 3D-G@rGO film electrode exhibits greatly improved K-storage performance with a reversible capacity of 452.8 mAh g-1 at 0.1 C and a capacity retention rate of 80.4% after 100 cycles. It also presents excellent rate capability with a high specific capacity of 139.1 and 94.2 mAh g-1 maintained at 2 and 5 C, respectively. The proposed self-propagating reduction strategy to construct a three-dimensional self-supporting structure is a viable route to improve the structural stability and potassium storage performance of graphite anodes.

This study first draws inspiration from the dual biomimetic design of plant cell walls and honeycomb structures, drawing on their structural characteristics to design a flexible shell structure that can achieve significant deformation and withstand large loads. Based on the staggered bonding of this flexible shell structure, we propose a new design scheme for a large-load pneumatic soft arm and establish a mathematical model for its flexibility and load capacity. The extension and bending deformation of this new type of soft arm come from the geometric variability of flexible shell structures, which can be controlled through two switches, namely, deflation and inflation, to achieve extension or bending actions. The experimental results show that under a driving pressure within the range of 150 kpa, the maximum elongation of the soft arm reaches 23.17 cm, the maximum bending angle is 94.2 degrees, and the maximum load is 2.83 N. This type of soft arm designed based on dual bionic inspiration can have both a high load capacity and flexibility. The research results provide new ideas and methods for the development of high-load soft arms, which are expected to expand from laboratories to multiple fields.

Flexible piezoresistive sensors are in high demand in areas such as wearable devices, electronic skin, and human-machine interfaces due to their advantageous features, including low power consumption, excellent bending stability, broad testing pressure range, and simple manufacturing technology. With the advancement of intelligent technology, higher requirements for the sensitivity, accuracy, response time, measurement range, and weather resistance of piezoresistive sensors are emerging. Due to the designability of polymer porous materials and conductive phases, and with more multivariate combinations, it is possible to achieve higher sensitivity and lower detection limits, which are more promising than traditional flexible sensor materials. Based on this, this work reviews recent advancements in research on flexible pressure sensors utilizing polymer porous materials. Furthermore, this review examines sensor performance optimization and development from the perspectives of three-dimensional porous flexible substrate regulation, sensing material selection and composite technology, and substrate and sensing material structure design.

UNASSIGNED: Falls are the leading cause of accidental death among older persons, with postmenopausal women facing a greater hazard of falling due to osteoporosis. This study aimed to examine the effects of Taijiquan practice on balance control and functional fitness in at-risk females.
UNASSIGNED: Chinese women who self-reported a tendency to fall and had a baseline one-leg stand test time (4.1 s in the Taijiquan group) below the national average for their age group (60-64 years: 10.9 s, 65-69 years: 9.9 s) were assigned to either a control group (n = 26, mean age = 63.9 years) or a Taijiquan group (n = 24, mean age = 63.9 years). The Taijiquan group participated in a 12-week supervised intervention, while the control group maintained their daily activities. The average duration of each exercise session was 52 min. Static balance and functional fitness were assessed at the beginning and end of the intervention.
UNASSIGNED: After 12 weeks, the Taijiquan group significantly outperformed the control group in terms of balance, flexibility, and muscular fitness (all p < 0.05). Participants in the Taijiquan group improved their one-leg stand by 61.0% (+2.5 s, Hedge\'s g = 0.85), arm curl by 8.3% (+1.7 repetitions, g = 0.53), handgrip strength by 8.3% (+1.9 kg, g = 0.65), and sit-and-reach by 163.2% (+6.2 cm, g = 1.17).
UNASSIGNED: The improvement in balance, coupled with other functional fitness benefits, suggests that Taijiquan could serve as a useful exercise for older women with an elevated risk of falling.

Flexibility of nanomaterials is challenging but worthy to tune for biomedical applications. Biocompatible silica nanomaterials are under extensive exploration but are rarely observed to exhibit flexibility despite the polymeric nature. Herein, a facile one-step route is reported to ultrathin flexible silica nanosheets (NSs), whose low thickness and high diameter-to-thickness ratio enables folding. Thickness and diameter can be readily tuned to enable controlled flexibility. Mechanism study reveals that beyond the commonly used surfactant, the \"uncommon\" one bearing two hydrophobic tails play a guiding role in producing sheeted/layered/shelled structures, while addition of ethanol appropriately relieved the strong interfacial tension of the assembled surfactants, which will otherwise produce large curled sheeted structures. With these ultrathin NSs, it is further shown that the cellular preference for particle shape and rigidity is highly dependent on surface chemistry of nanoparticles: under high particle-cell affinity, NSs, and especially the flexible ones will be preferred by mammalian cells for internalization or attachment, while this preference is basically invalid when the affinity is low. Therefore, properties of the ultrathin silica NSs can be effectively expanded and empowered by surface chemistry to realize improved bio-sensing or drug delivery.

With low density, high porosity, and outstanding physicochemical stability, ceramic nanowire aerogels and sponges exhibit various interesting properties. Herein, an ultrathin silica nanowire aerogel (SiO2 NWs-A) was achieved via a facile chemical vapor deposition route. In addition to good mechanical and thermal performances, properties resulting from active water-aerogel interactions are revealed, i.e., outstanding transparency, strong capillary effect, enhanced compressive strength (a reversible strain of ∼62%), switchable wettability and robust shape retention ability when filled with water. The physical mechanism related to these interesting properties is demonstrated basically according to its unique features (distinctly reduced nanowire diameter, enriched nanoscopic gap channels, and reinforced network). To demonstrate the superiority, an advantageous solar vapor generation system (hydrophilic NWs-A/reduced graphene oxide (rGO)/ hydrophobic NWs-A) was obtained by integrating these favorable characteristics, giving rise to remarkably promoted vapor evaporation rate and energy efficiency compared to the rGO hydrophobic NWs-A device. These results contribute to the structural design and functional exploration of nanowire aerogels.