FAIR

FAIR
  • 文章类型: Journal Article
    脂质组学研究的迅速增加导致了社区内部的合作努力,以建立生产的标准和标准,记录,和传播数据。创建一个易于使用的动态检查表,将有关脂质组学实验的关键信息浓缩为通用术语,将增强该领域的一致性,可比性,和可重复性。这里,我们描述了已建立的脂质组学最低报告清单的结构和原理,以提高脂质组学研究的透明度.
    The rapid increase in lipidomic studies has led to a collaborative effort within the community to establish standards and criteria for producing, documenting, and disseminating data. Creating a dynamic easy-to-use checklist that condenses key information about lipidomic experiments into common terminology will enhance the field\'s consistency, comparability, and repeatability. Here, we describe the structure and rationale of the established Lipidomics Minimal Reporting Checklist to increase transparency in lipidomics research.
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  • 文章类型: Journal Article
    第三方惩罚发生在人际交往中以维持社会规范,并且受到互动个体特征的强烈影响。在社会交往中,高度是首先观察到的引人注目的身体外观特征,身高劣势可能严重影响男性的行为和心理健康。在这里,我们通过时频分析和脑电图超扫描探讨了身高劣势对第三方惩罚的影响.两名参与者在身高比较后被随机指定为接受者和第三方,并指示完成第三方惩罚任务。与第三方的身高高于收件人的身高相比,当第三方的身高较低时,惩罚率和转移金额明显较高。只有对于非常不公平的报价,当第三方的高度较低时,θ功率明显较大。当第三方的身高较低时,接受者和第三方之间的脑间同步明显更强。与公平和中等不公平的报价相比,对于非常不公平的报价,大脑间的同步性最强。我们的发现表明,身高劣势引起的愤怒和声誉关注促进了第三方惩罚和大脑间的同步。本研究丰富了研究视角,拓展了拿破仑情结理论的应用。
    Third-party punishment occurs in interpersonal interactions to sustain social norms, and is strongly influenced by the characteristics of the interacting individuals. During social interactions, height is the striking physical appearance features first observed, height disadvantage may critically influence men\'s behavior and mental health. Herein, we explored the influence of height disadvantage on third-party punishment through time-frequency analysis and electroencephalography hyperscanning. Two participants were randomly designated as the recipient and third party after height comparison and instructed to complete third-party punishment task. Compared with when the third party\'s height is higher than the recipient\'s height, when the third party\'s height is lower, the punishment rate and transfer amount were significantly higher. Only for highly unfair offers, the theta power was significantly greater when the third party\'s height was lower. The inter-brain synchronization between the recipient and the third party was significantly stronger when the third party\'s height was lower. Compared with the fair and medium unfair offers, the inter-brain synchronization was strongest for highly unfair offers. Our findings indicate that the height disadvantage-induced anger and reputation concern promote third-party punishment and inter-brain synchronization. This study enriches research perspective and expands the application of the theory of Napoleon complex.
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  • 文章类型: Journal Article
    基因的标准化命名法,基因产物,同工型对于防止歧义和实现科学数据的清晰交流至关重要,促进有效的生物存储和数据共享。标准化基因型命名法,它描述了特定菌株中存在的与野生型参考菌株不同的等位基因,对于最大化研究影响并确保将基因型与表型联系起来的结果是可察觉的,可访问,互操作,可重用(FAIR)。在本出版物中,我们扩展了裂变酵母进化枝基因命名指南,以支持PomBase的策展工作(www.pombase.org),裂殖酵母模型生物数据库。此更新介绍了非编码RNA基因的命名指南,遵循人类基因组组织基因命名委员会的规定。此外,我们对最初于1987年发布的等位基因和基因型命名指南进行了重大更新,以标准化裂变酵母遗传工具箱所实现的各种遗传修饰范围。这些更新的指南反映了许多裂变酵母研究人员之间的社区共识。采用这些规则将提高基因和基因型命名法的一致性,并促进机器可读性和自动化实体识别裂变酵母基因和等位基因在出版物或数据集。总之,我们更新的指南为裂变酵母研究界提供了宝贵的资源,促进一致性,清晰度,遗传数据共享和解释中的公平。
    Standardized nomenclature for genes, gene products, and isoforms is crucial to prevent ambiguity and enable clear communication of scientific data, facilitating efficient biocuration and data sharing. Standardized genotype nomenclature, which describes alleles present in a specific strain that differ from those in the wild-type reference strain, is equally essential to maximize research impact and ensure that results linking genotypes to phenotypes are Findable, Accessible, Interoperable, and Reusable (FAIR). In this publication, we extend the fission yeast clade gene nomenclature guidelines to support the curation efforts at PomBase (www.pombase.org), the Schizosaccharomyces pombe Model Organism Database. This update introduces nomenclature guidelines for noncoding RNA genes, following those set forth by the Human Genome Organisation Gene Nomenclature Committee. Additionally, we provide a significant update to the allele and genotype nomenclature guidelines originally published in 1987, to standardize the diverse range of genetic modifications enabled by the fission yeast genetic toolbox. These updated guidelines reflect a community consensus between numerous fission yeast researchers. Adoption of these rules will improve consistency in gene and genotype nomenclature, and facilitate machine-readability and automated entity recognition of fission yeast genes and alleles in publications or datasets. In conclusion, our updated guidelines provide a valuable resource for the fission yeast research community, promoting consistency, clarity, and FAIRness in genetic data sharing and interpretation.
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  • 文章类型: Journal Article
    音乐能否影响道德判断在音乐美学和音乐哲学中存在争议。审美自主性指出,音乐因其歌词或特定的语境而具有道德教育功能。解决分歧的关键是选择没有歌词或特定上下文的绝对音乐作为引出材料。在这项研究中,招募了84名参与者,并随机分为三组,以在听完不同的刺激后完成最后通牒游戏(UG):绝对音乐,白噪声,也没有声音.行为结果表明,在音乐组中,参与者对不公平报价的接受度明显较低。此外,与其他不公平条件相比,音乐组的参与者拒绝不公平提议的反应时间更短。然而,ERP比较显示内侧额叶负(MFN)振幅无显著差异,这反映了公平水平,在接受或拒绝适度不公平的提议的音乐组和无声音组之间。大脑网络分析显示,音乐小组的参与者表现出更强的奖励电路激活,包括腹侧纹状体,在拒绝不公平报价的决策过程中,尤其是在做出决定之前,与无声音组相比。这些结果表明,绝对音乐可以影响公平的决策。音乐激活的奖励替代地补偿了参与者因在不公平的报价中选择自我利益而获得的奖励,参与者不再需要在自利和公平规范之间做出选择,因此参与者由于不公平报价所引起的负面情绪而拒绝了不公平报价。
    Whether music can influence moral judgment is controversial in the aesthetics and philosophy of music. Aesthetic Autonomy pointed out that music had a morally educational function because of its lyrics or a particular context. The key to resolving the divergence is to select absolute music without lyrics or specific context as the eliciting material. In this study, 84 participants were recruited and randomly divided into three groups to complete the Ultimatum Game (UG) after listening to different stimuli: absolute music, white noise, and no sound. Behavioral results indicated that the participants\' acceptance of unfair offers was significantly lower in the music group. Also, participants in the music group have a shorter reaction time for rejecting an unfair offer than other unfair conditions. However, ERP comparison showed no significant difference in medial frontal negativity (MFN) amplitude, which reflects fairness levels, between the music group and the no sound group for either accepting or rejecting the moderately unfair offer. Brain network analyses revealed that participants in the music group showed stronger activation of rewarding circuits, including the ventral striatum, during the decision-making process of rejecting unfair offers, before the decision especially, compared to the no sound group. These results suggest that absolute music can influence fair decision-making. The reward activated by music compensates participants vicariously for the reward they receive for choosing self-interest in an unfair offer, participants no longer have to choose between self-interest and fairness norms, so the participants reject the unfair offer due to the negative emotions induced by the unfair offer.
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  • 文章类型: Journal Article
    通过数字化实现一个健康(OH)的运营是部署数字技术(包括人工智能(AI),大数据和相关的数字技术),使我们有能力应对日益增长的气候紧急情况和对人类的相关威胁,动植物健康。关于一个数字健康(ODH)的概念,本文考虑了数字功能如何通过新的更深入的见解来帮助克服OH的“操作刹车”,更好的预测,和更有针对性或更精确的预防策略和公共卫生对策。然而,数据格局是支离破碎的,对某些类型数据的访问作为个人越来越受到限制,社区和国家寻求对从他们那里获取的数据进行更大的控制。本文建议建立一个以公平和公平为中心的全球ODH框架,以促进OH所有关键知识领域的数据共享,并为人类-动物-生态系统界面的挑战设计数据驱动的解决方案。它首先考虑与以下方面有关的数据格局:(1)人类和人口健康;(2)病原体;(3)动植物健康;(4)生态系统和生物多样性。然后考虑了先进基因测序技术应用的复杂性,重点关注当前关于数字(基因)测序信息(DSI)等某些类型的数据是否应保持公开和免费获取的辩论。拟议的ODH框架必须以至少三种不同的方式增强《生物多样性公约》(CBD)名古屋议定书目前规定的现有获取和惠益分享(ABS)框架。首先,ODH框架应适用于所有遗传资源和数据,包括DSI,无论是来自人类还是非人类。第二,应该执行公平原则,注重公平和公平的利益分享。第三,ODH框架应采用多边方法进行数据共享(例如通过联邦数据系统)和ABS。通过将OH操作为ODH,我们更有可能保护和恢复自然栖息地,确保所有生物的健康和福祉,从而实现《生物多样性公约》下的《2020年后全球生物多样性框架》中规定的目标。
    The operationalization of One Health (OH) through digitalization is a means to deploy digital technologies (including Artificial Intelligence (AI), big data and related digital technologies) to better capacitate us to deal with growing climate exigency and related threats to human, animal and plant health. With reference to the concept of One Digital Health (ODH), this paper considers how digital capabilities can help to overcome \'operational brakes\' in OH through new and deeper insights, better predictions, and more targeted or precise preventive strategies and public health countermeasures. However, the data landscape is fragmented and access to certain types of data is increasingly restrictive as individuals, communities and countries seek to assert greater control over data taken from them. This paper proposes for a dedicated global ODH framework-centered on fairness and equity-to be established to promote data-sharing across all the key knowledge domains of OH and to devise data-driven solutions to challenges in the human-animal-ecosystems interface. It first considers the data landscape in relation to: (1) Human and population health; (2) Pathogens; (3) Animal and plant health; and (4) Ecosystems and biodiversity. The complexification from the application of advance genetic sequencing technology is then considered, with focus on current debates over whether certain types of data like digital (genetic) sequencing information (DSI) should remain openly and freely accessible. The proposed ODH framework must augment the existing access and benefit sharing (ABS) framework currently prescribed under the Nagoya Protocol to the Convention on Biological Diversity (CBD) in at least three different ways. First, the ODH framework should apply to all genetic resources and data, including DSI, whether from humans or non-humans. Second, the FAIRER principles should be implemented, with focus on fair and equitable benefit-sharing. Third, the ODH framework should adopt multilateral approaches to data sharing (such as through federated data systems) and to ABS. By operationalizing OH as ODH, we are more likely to be able to protect and restore natural habitats, secure the health and well-being of all living things, and thereby realize the goals set out in the post-2020 Global Biodiversity Framework under the CBD.
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  • 文章类型: Journal Article
    不像其他生物,人类发展了与遗传无关的陌生人合作的能力,并倾向于遵守社会规范。然而,人类在各种情况下都偏离了社会规范。本研究使用修改后的最后通牒博弈来探讨人类为何偏离社会规范以及如何促进其亲社会行为。在研究1中,参与者被要求想象与匿名对应人一起完成一项任务并获得一定金额的资金(例如,¥10)。计算机随机分配资金以有利于参与者(例如,9:1或8:2)。参与者应决定是接受还是拒绝这种自利的划分。在无风险条件下,如果参与者拒绝自我利益分割,就会发生绝对公平的资金重新分配(例如,5:5或6:4)。相比之下,在风险条件下,其他受益的货币重新划分(例如,1:9或2:8)如果参与者拒绝自我受益的划分,将发生。结果涉及40名大学生,表现出主要的病情影响。在风险条件下接受自我利益划分的频率高于在非风险条件下接受自我利益划分的频率。因此,遵守社会规范的基础是保护物质资源。在研究2中,我们使用经济或道德奖励来补偿遵守规范后的经济损失。涉及28名大学生的结果显示了显着的补偿效果。奖励,包括道德赞美,有效地减少了自私的选择。这些发现通过强调内部,基于公平的物质和道德需求之间的平衡,以及道德赞美在促进亲社会行为中的作用。
    Unlike other creatures, humans developed the ability to cooperate with genetically unrelated strangers and a tendency to comply with social norms. However, humans deviate from social norms in various situations. This study used the modified ultimatum game to explore why humans deviate from social norms and how their prosocial behavior can be promoted. In Study 1, participants were asked to imagine working with an anonymous counterpart to complete a task and obtain a certain amount of money (e.g., ¥10). The computer divided the money randomly in favor of the participant (e.g., 9:1 or 8:2). Participants should decide whether to accept or reject such a self-benefiting division. In the non-risk condition, an absolutely fair redivision of money would take place if participants reject self-benefiting division (e.g., 5:5 or 6:4). By contrast, in the risk condition, other-benefiting redivision of money (e.g., 1:9 or 2:8) would take place if participants rejected the self-benefiting division. Results involving 40 college students showed the main effect of condition. The frequency of accepting self-benefiting division in the risk condition was higher than that in the non-risk condition. As such, compliance with social norms is based on the preservation of material resources. In Study 2, we used economic or moral rewards to compensate for economic loss following compliance with the norm. Results involving 28 college students revealed a significant effect of compensation. The rewards, including moral praise, effectively decreased selfish choices. These findings extend previous studies on social norm compliance by emphasizing the importance of internal, fairness-based balance between material and moral needs, as well as the role of moral praise in promoting prosocial behavior.
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