FAIR

FAIR
  • 文章类型: Journal Article
    Open science (OS) awareness and skills are increasingly becoming an essential part of everyday scientific work as e.g., many journals require authors to share data. However, following an OS workflow can seem challenging at first. Thus, instructions by journals and other guidelines are important. But how comprehensive are they in the field of ecology and evolutionary biology (Ecol Evol)? To find this out, we reviewed 20 published OS guideline articles aimed for ecologists or evolutionary biologists, together with the data policies of 17 Ecol Evol journals to chart the current landscape of OS guidelines in the field, find potential gaps, identify field-specific barriers for OS and discuss solutions to overcome these challenges. We found that many of the guideline articles covered similar topics, despite being written for a narrow field or specific target audience. Likewise, many of the guideline articles mentioned similar obstacles that could hinder or postpone a transition to open data sharing. Thus, there could be a need for a more widely known, general OS guideline for Ecol Evol. Following the same guideline could also enhance the uniformity of the OS practices carried on in the field. However, some topics, like long-term experiments and physical samples, were mentioned surprisingly seldom, although they are typical issues in Ecol Evol. Of the journals, 15 out of 17 expected or at least encouraged data sharing either for all articles or under specific conditions, e.g. for registered reports and 10 of those required data sharing at the submission phase. The coverage of journal data policies varied greatly between journals, from practically non-existing to very extensive. As journals can contribute greatly by leading the way and making open data useful, we recommend that the publishers and journals would invest in clear and comprehensive data policies and instructions for authors.
    Avoimen tieteen ymmärrys ja taitojen hallinta on yhä tärkeämpi osa tutkijan arkea, sillä esimerkiksi monet tieteelliset lehdet odottavat aineiston avointa jakamista. Avoimen tieteen työtapojen noudattaminen voi kuitenkin tuntua alkuun haastavalta, minkä vuoksi esimerkiksi tieteellisten lehtien ja muiden tahojen laatimat ohjeet ovat tärkeitä. Mutta kuinka kattavia ne ovat ekologian ja evoluutiobiologian alalla? Kävimme läpi 20 julkaistua ekologeille tai evoluutiobiologeille suunnattua avoimen tieteen ohjeistusta sekä 17 ekologian ja evoluutiobiologian tieteellisen lehden datakäytännöt, tarkoituksenamme kartoittaa alojen avoimen tieteen ohjeiden nykytilaa, löytää mahdollisia puutteita, tunnistaa alakohtaisia esteitä avoimen tieteen käytäntöjen toteutumiselle sekä keskustella ratkaisuista, joilla nämä haasteet voitaisiin ratkaista. Havaitsimme, että monet ohjeistukset käsittelivät samankaltaisia aiheita, vaikka ne oli tarkoitettu kapealle erityisalalle tai suunnattu hyvin rajoitetulle kohderyhmälle. Samoin monissa ohjeistuksissa mainittiin samankaltaisia aineistojen avoimen jakamisen hidastamista tai estämistä aiheuttavia haasteita. Toiset aiheet, kuten pitkäaikaiskokeet ja fyysiset näytteet, sen sijaan mainittiin yllättävän harvoin, vaikka niissä on tyypillisiä ekologian ja evoluutiobiologian alojen haasteita. Tieteellisistä lehdistä 15:ssä 17:sta vaadittiin tai vähintään kannustettiin jakamaan aineisto avoimesti joko kaikkien artikkelien osalta tai tietyin edellytyksin, esim. rekisteröityjen tutkimusraporttien osalta. Lisäksi 10 näistä lehdistä edellytti aineiston avointa jakamista jo submittointivaiheessa. Tieteellisten lehtien aineisto‐ohjeiden kattavuus vaihteli suuresti lehtien välillä, käytännössä olemattomasta hyvin laajaan. Koska tieteellisillä lehdillä on suuri vaikutusvalta avoimen tieteen käytäntöjen edistämiseen, suosittelemme kustantajia ja lehtiä panostamaan selkeisiin ja kattaviin aineistolinjauksiin ja ohjeistuksiin.
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  • 文章类型: Journal Article
    增强适应性免疫受体库测序(AIRR-seq)数据分析的可重复性和可理解性对于科学进步至关重要。本研究提供了可重现的AIRR-seq数据分析指南,以及带有全面文档的现成管道集合。为此,使用ViaFoundry实现了十个常见的管道,管道管理和自动化的用户友好的界面。这伴随着版本化的容器,文档和归档功能。强调了预处理分析步骤的自动化以及根据特定研究需求修改管道参数的能力。AIRR-seq数据分析对不同的参数和设置高度敏感;使用此处提供的指南,证明了重现以前发表的结果的能力。这项工作促进了透明度,再现性,以及在AIRR-SEQ数据分析方面的合作,作为处理和记录其他研究领域生物信息学管道的模型。
    Enhancing the reproducibility and comprehension of adaptive immune receptor repertoire sequencing (AIRR-seq) data analysis is critical for scientific progress. This study presents guidelines for reproducible AIRR-seq data analysis, and a collection of ready-to-use pipelines with comprehensive documentation. To this end, ten common pipelines were implemented using ViaFoundry, a user-friendly interface for pipeline management and automation. This is accompanied by versioned containers, documentation and archiving capabilities. The automation of pre-processing analysis steps and the ability to modify pipeline parameters according to specific research needs are emphasized. AIRR-seq data analysis is highly sensitive to varying parameters and setups; using the guidelines presented here, the ability to reproduce previously published results is demonstrated. This work promotes transparency, reproducibility, and collaboration in AIRR-seq data analysis, serving as a model for handling and documenting bioinformatics pipelines in other research domains.
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  • 文章类型: Journal Article
    基因的标准化命名法,基因产物,同工型对于防止歧义和实现科学数据的清晰交流至关重要,促进有效的生物存储和数据共享。标准化基因型命名法,它描述了特定菌株中存在的与野生型参考菌株不同的等位基因,对于最大化研究影响并确保将基因型与表型联系起来的结果是可察觉的,可访问,互操作,可重用(FAIR)。在本出版物中,我们扩展了裂变酵母进化枝基因命名指南,以支持PomBase的策展工作(www.pombase.org),裂殖酵母模型生物数据库。此更新介绍了非编码RNA基因的命名指南,遵循人类基因组组织基因命名委员会的规定。此外,我们对最初于1987年发布的等位基因和基因型命名指南进行了重大更新,以标准化裂变酵母遗传工具箱所实现的各种遗传修饰范围。这些更新的指南反映了许多裂变酵母研究人员之间的社区共识。采用这些规则将提高基因和基因型命名法的一致性,并促进机器可读性和自动化实体识别裂变酵母基因和等位基因在出版物或数据集。总之,我们更新的指南为裂变酵母研究界提供了宝贵的资源,促进一致性,清晰度,遗传数据共享和解释中的公平。
    Standardized nomenclature for genes, gene products, and isoforms is crucial to prevent ambiguity and enable clear communication of scientific data, facilitating efficient biocuration and data sharing. Standardized genotype nomenclature, which describes alleles present in a specific strain that differ from those in the wild-type reference strain, is equally essential to maximize research impact and ensure that results linking genotypes to phenotypes are Findable, Accessible, Interoperable, and Reusable (FAIR). In this publication, we extend the fission yeast clade gene nomenclature guidelines to support the curation efforts at PomBase (www.pombase.org), the Schizosaccharomyces pombe Model Organism Database. This update introduces nomenclature guidelines for noncoding RNA genes, following those set forth by the Human Genome Organisation Gene Nomenclature Committee. Additionally, we provide a significant update to the allele and genotype nomenclature guidelines originally published in 1987, to standardize the diverse range of genetic modifications enabled by the fission yeast genetic toolbox. These updated guidelines reflect a community consensus between numerous fission yeast researchers. Adoption of these rules will improve consistency in gene and genotype nomenclature, and facilitate machine-readability and automated entity recognition of fission yeast genes and alleles in publications or datasets. In conclusion, our updated guidelines provide a valuable resource for the fission yeast research community, promoting consistency, clarity, and FAIRness in genetic data sharing and interpretation.
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  • 文章类型: Journal Article
    2016年,发表了《减肥手术后康复增强指南》(G16),并在2022年发布了更新(G22)。建议的分级,评估,发展,和评估(等级),强调两个指南的证据水平(LoE),已执行。还对方法进行了概述,考虑以下问题:如何改进研究,未来可以用数据做什么,以及如何进行更多的合作?这两个指南都没有解释LoE结论是如何得出关于偏见风险的。也有可能形成一个全球联盟,处理减肥研究,它可以作为所有相关数据的存储库。确保这些数据是公平的(可查找性,可访问性,互操作性,可重用性)合规,并使用此数据制定未来的指南将使临床医生和患者受益。
    In 2016, the Enhanced Recovery After Bariatric Surgery guidelines (G16) was published, and in 2022, an update to it was released (G22). Grading of recommendations, assessment, development, and evaluations (GRADE), emphasizing the level of evidence (LoE) of both the guidelines, was performed. An overview of methodology was also performed, considering the following questions: how can research be improved, what can be done in the future using data, and how to collaborate more? Both guidelines did not explain how the LoE conclusions were derived regarding the risk of bias. There is also potential for forming a global consortium that deals with bariatric research, which can serve as a repository for all relevant data. Ensuring that this data is FAIR (findability, accessibility, interoperability, reusability) compliant and using this data to formulate future guidelines will benefit clinicians and patients alike.
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  • 文章类型: Journal Article
    竞争前数据共享可以为制药行业提供显著的好处,通过更明智的测试策略和通过汇集数据获得的知识,减少新药上市所需的时间和成本。如果共享了足够的数据并可以进行共同分析,那么它还可以提供减少动物使用和改善毒理学影响的计算机预测的潜力。通过应用公平指导原则,可以进一步增强数据共享的好处。减少策展花费的时间,转换和聚合数据集,并允许更多时间进行数据挖掘和分析。我们希望通过描述作为通过综合知识管理(eTRANSAFE)项目增强横向安全性评估的一部分的经验教训,来促进其他组织和计划的数据共享。创新药物倡议(IMI)合作伙伴关系,旨在将公开可用的数据源与制药组织捐赠的专有临床前和临床数据进行整合。描述了促进信任和克服数据共享的非技术障碍的方法,例如法律和IPR(知识产权),包括制药组织通常期望得到满足的安全要求。我们同意制药合作伙伴之间就决定标准达成的共识,这些标准将被纳入内部审批程序,以决定是否可以共享数据。我们还报告了在特定数据字段上达成的共识,这些数据将被排除在敏感的临床前安全性和药理学数据的共享之外,否则将无法共享。
    Pre-competitive data sharing can offer the pharmaceutical industry significant benefits in terms of reducing the time and costs involved in getting a new drug to market through more informed testing strategies and knowledge gained by pooling data. If sufficient data is shared and can be co-analyzed, then it can also offer the potential for reduced animal usage and improvements in the in silico prediction of toxicological effects. Data sharing benefits can be further enhanced by applying the FAIR Guiding Principles, reducing time spent curating, transforming and aggregating datasets and allowing more time for data mining and analysis. We hope to facilitate data sharing by other organizations and initiatives by describing lessons learned as part of the Enhancing TRANslational SAFEty Assessment through Integrative Knowledge Management (eTRANSAFE) project, an Innovative Medicines Initiative (IMI) partnership which aims to integrate publicly available data sources with proprietary preclinical and clinical data donated by pharmaceutical organizations. Methods to foster trust and overcome non-technical barriers to data sharing such as legal and IPR (intellectual property rights) are described, including the security requirements that pharmaceutical organizations generally expect to be met. We share the consensus achieved among pharmaceutical partners on decision criteria to be included in internal clearance pro­cedures used to decide if data can be shared. We also report on the consensus achieved on specific data fields to be excluded from sharing for sensitive preclinical safety and pharmacology data that could otherwise not be shared.
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  • 文章类型: Evaluation Study
    This project aimed to develop and propose a standardised reporting guideline for kidney disease research and clinical data reporting, in order to improve kidney disease data quality and integrity, and combat challenges associated with the management and challenges of \'Big Data\'.
    A list of recommendations was proposed for the reporting guideline based on the systematic review and consolidation of previously published data collection and reporting standards, including PhenX measures and Minimal Information about a Proteomics Experiment (MIAPE). Thereafter, these recommendations were reviewed by domain-specialists using an online survey, developed in Research Electronic Data Capture (REDCap). Following interpretation and consolidation of the survey results, the recommendations were mapped to existing ontologies using Zooma, Ontology Lookup Service and the Bioportal search engine. Additionally, an associated eXtensible Markup Language schema was created for the REDCap implementation to increase user friendliness and adoption.
    The online survey was completed by 53 respondents; the majority of respondents were dual clinician-researchers (57%), based in Australia (35%), Africa (33%) and North America (22%). Data elements within the reporting standard were identified as participant-level, study-level and experiment-level information, further subdivided into essential or optional information.
    The reporting guideline is readily employable for kidney disease research projects, and also adaptable for clinical utility. The adoption of the reporting guideline in kidney disease research can increase data quality and the value for long-term preservation, ensuring researchers gain the maximum benefit from their collected and generated data.
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