背景:观察有或没有下眼睑眼睑的儿童患者睑板腺的形态和功能变化。
方法:在这项前瞻性观察研究中,55例患者的55只眼(24例男性,31名女性;平均年龄±SD,9.82±2.59岁;范围6-14岁)和60只对照组的60只眼睛(32名男性,28名女性;平均年龄±SD,包括10.57±2.75年;范围6-14年)。进行了以下测试:通过裂隙灯检查眼睑边缘异常,非侵入性角膜造影破裂时间的测量(NIKBUT),通过非接触式睑板腺造影评估睑板腺缺失的分级(睑板腺造影评分),睑板腺的形态学变化(变薄,扩张和失真),Schirmer1测试的泪液产量,睑脂质量和睑板腺表达能力的分级。
结果:睑板腺的形态学改变在上眼睑组(56.36%)比对照组(28.33%)更为常见(p=0.002)。上眼组的皮脂质量比对照组差(p=0.009),和NIKBUT在上眼组明显短于对照组(p=0.012)。Schirmer1检验没有显著差异,睑板腺的可表达性,两组之间的眼睑边缘异常评分或总评分。上眼睑睑板腺的形态变化(38.18%)比下眼睑(20%)更常见(p=0.036)。并且上眼睑的肌造影评分高于下眼睑(p=0.001)。
结论:儿童下睑睑上睑板腺有形态学和功能改变。虽然倒置的睫毛位于下眼睑,睑板腺的形态变化在上眼睑更为常见。
BACKGROUND: To observe morphologic and functional changes in meibomian glands in pediatric patients with and without lower eyelid epiblepharon.
METHODS: In this prospective observation study, 55 eyes of 55 patients( 24 males, 31 females; mean age ± SD,9.82 ± 2.59 years; range 6-14 years) and 60 eyes of 60 controls ( 32 males, 28 females; mean age ± SD,10.57 ± 2.75 years; range 6-14 years) were included. The following tests were performed: eyelid margin abnormality by slit-lamp examination, measurement of noninvasive keratographic break-up time (NIKBUT), grading of absence of meibomian gland (meibography score) assessed with noncontact meibography, morphologic changes of meibomian glands (thinning, dilatation and distortion), tear production by the Schirmer 1 test, and grading of meibum quality and meibomian gland expressibility.
RESULTS: The morphologic changes in meibomian glands were more common in the epiblepharon group (56.36%) than in the control group (28.33%) (p = 0.002). The meibum quality was worse in the epiblepharon group than in the control group (p = 0.009), and the NIKBUT was significantly shorter in the epiblepharon group than in the control group (p = 0.012). There was no significant difference in the Schirmer 1 test, meibomian gland expressibility, eyelid margin abnormality score or total meibography score between the two groups. Morphologic changes in the meibomian glands in the upper eyelids (38.18%) were more common than those in the lower eyelids (20%) (p = 0.036) in the epiblepharon group, and the meibography score was higher in the upper eyelids than in the lower eyelids (p = 0.001).
CONCLUSIONS: There are morphological and functional changes in meibomian glands in pediatric patients with lower eyelid epiblepharon. Although the inverted eyelashes were located in the lower eyelid, morphological changes in the meibomian glands were more common in the upper eyelid.