背景:阻塞性睡眠呼吸暂停(OSA)与眼部疾病发展的关系尚不清楚。本系统综述和荟萃分析试图总结和分析文献中OSA与眼部疾病之间的关联。
方法:PubMed,EMBASE,谷歌学者,网络科学,和Scopus数据库从1901年至2022年7月根据系统评价和荟萃分析(PRISMA)的首选报告进行搜索。我们的主要结果评估了OSA与发展眼睑松弛综合征(FES)的几率之间的关联,青光眼,非动脉炎性前部缺血性视神经病变(NAION),视网膜静脉阻塞(RVO),圆锥角膜(KC),特发性颅内高压(IIH),年龄相关性黄斑变性(AMD),和中心性浆液性脉络膜视网膜病变(CSR),通过95%置信区间计算的比值比。
结果:纳入49项研究进行系统评价和荟萃分析。NAION的合并OR估计值最高[3.98(95%CI2.38,6.66)],其次是FES[3.68(95%CI2.18,6.20)],RVO[2.71(95%CI1.83,4.00)],企业社会责任[2.28(95%CI0.65,7.97)],KC[1.87(95%CI1.16,2.99)],青光眼[1.49(95%CI1.16,1.91)],IIH[1.29(95%CI0.33,5.01)],和AMD[0.92[95%CI0.24,3.58]除IIH和AMD外,所有观察到的关联均显著(p<0.001)。
结论:OSA与NAION显著相关,FES,RVO,CSR,KC,和青光眼。临床医生应该被告知这些关联,以便尽早认识到,诊断,眼部疾病的治疗可以在高危人群中解决,早期转诊眼科服务是为了防止视力障碍。同样,眼科医生对患有上述任何疾病的患者应考虑筛查和转诊患者以评估可能的OSA.
BACKGROUND: The association of obstructive sleep apnea (OSA) with development of eye diseases is unclear. This current systematic
review and meta-analysis attempts to summarize and analyze associations between OSA and ocular disorders in the literature.
METHODS: PubMed, EMBASE, Google Scholar, Web Of Science, and Scopus databases were searched from 1901 to July 2022 in accordance with the Preferred Reporting in Systematic
Review & Meta-Analysis (PRISMA). Our primary outcome assessed the association between OSA and the odds of developing floppy eyelid syndrome (FES), glaucoma, non-arteritic anterior ischemic optic neuropathy (NAION), retinal vein occlusion (RVO), keratoconus (KC), idiopathic intracranial hypertension (IIH), age-related macular degeneration (AMD), and central serous chorioretinopathy (CSR) through odds ratio calculated at the 95% confidence interval.
RESULTS: Forty-nine studies were included for systematic
review and meta-analysis. The pooled OR estimate was highest for NAION [3.98 (95% CI 2.38, 6.66)], followed by FES [3.68 (95% CI 2.18, 6.20)], RVO [2.71(95% CI 1.83, 4.00)], CSR [2.28 (95% CI 0.65, 7.97)], KC [1.87 (95% CI 1.16, 2.99)], glaucoma [1.49 (95% CI 1.16, 1.91)], IIH [1.29 (95% CI 0.33, 5.01)], and AMD [0.92 [95% CI 0.24, 3.58] All observed associations were significant (p < 0.001) aside from IIH and AMD.
CONCLUSIONS: OSA is significantly associated with NAION, FES, RVO, CSR, KC, and glaucoma. Clinicians should be informed of these associations so early recognition, diagnosis, and treatment of eye disorders can be addressed in at-risk groups, and early referral to ophthalmic services is made to prevent vision disturbances. Similarly, ophthalmologists seeing patients with any of these conditions should consider screening and referring patients for assessment of possible OSA.