■骨骼肌功能障碍是导致慢性阻塞性肺疾病(COPD)患者运动受限的重要因素。尽管经常建议进行运动训练以提高患者的治疗效果,关于其确切影响的辩论仍在继续。
■这项研究的目的是评估耐力运动的有效性,力量训练和心肺健身联合运动(包括最大摄氧量,最大分钟通气量,和6分钟步行测试),下肢力量(通过腿部按压测量),COPD患者的生活质量(使用COPD评估测试)。通过对随机对照试验(RCT)进行系统评价和荟萃分析,我们的目标是为COPD患者提供量身定制的训练方法和强度建议,以改善他们的生活质量.
■荟萃分析包括10项运动康复计划的随机对照试验(RCT),涉及从电子数据库中检索的180名COPD患者(PubMed,科克伦图书馆,和Embase)。两名审稿人独立评估了主题相关性,试验质量,并提取数据进行荟萃分析。
■荟萃分析显示,与预测试相比,在不同的运动干预下,代表运动耐力的主要结果升高,例如最大摄氧量(VO2max(ml/kg/min))[SMD=0.40,95%CI(0.15,0.64)]和6分钟步行试验(6MWT)[MD=33.90,95%CI(25.25,42.55)],代表力量的主要结果也增加了,例如压腿(1RM)[MD=24.59,95%CI(16.08,33.11)],而次要结果如COPD评估测试(CAT)等生命评估恢复[MD=2.51,95%CI(2.01,3.00)],所有差异均具有统计学意义(p<0.05)。然而,最大分钟通气量(VEmax(L))[MD=0.91,95CI(3.61,5.43)]与试验后数据相比无统计学意义(p>0.05)。灵敏度测试数据稳定,结果可靠。我们对来自不同类型运动干预的数据进行分组,发现不同类型的运动会影响实验结果。
■运动干预对COPD患者的治疗具有积极作用,显著提高功能能力,有氧能力,和运动耐力,但要根据患者的病情进行个体化开发,以达到最佳的治疗效果。
UNASSIGNED: Skeletal muscle dysfunction is a significant factor contributing to exercise limitation in patients with chronic obstructive pulmonary disease (COPD). Although exercise training is often recommended to enhance patient outcomes, there continues to be ongoing debate regarding its exact effects.
UNASSIGNED: The aim of this study is to evaluate the effectiveness of endurance exercise, strength training and combined exercise on cardiorespiratory fitness (including maximal oxygen uptake, maximal minute ventilation, and the 6-minute walk test), strength of lower limbs (measured by leg press), and quality of life (using the COPD Assessment Test) in patients with COPD. By conducting a systematic review and meta-analysis of randomized controlled trials (RCTs), our objective is to provide tailored training methods and intensity recommendations for patients with COPD in order to improve their quality of life.
UNASSIGNED: The meta-analysis included 10 randomized controlled trials (RCTs) of exercise rehabilitation programs involving 180 patients with COPD that were retrieved from electronic databases (PubMed, Cochrane Library, and Embase). Two reviewers independently assessed the topical relevance, trial quality, and extracted data for the meta-analysis.
UNASSIGNED: Meta-analysis showed that primary outcomes representing exercise endurance were elevated under different exercise interventions compared to pre-test, such as maximal oxygen uptake (VO2max (ml/kg/min)) [SMD = 0.40, 95% CI (0.15, 0.64)] and the 6-min walk test (6MWT) [MD = 33.90, 95% CI (25.25, 42.55)], and primary outcomes representing strength also increased, such as leg press (1RM) [MD = 24.59, 95% CI (16.08, 33.11)], while secondary outcomes such as assessments of life such as the COPD Assessment Test (CAT) recovered [MD = 2.51, 95% CI (2.01, 3.00)], with all differences being statistically significant (p < 0.05). However, Maximum minute ventilation (VEmax (L)) [MD = 0.91, 95%CI (3.61, 5.43)] was not statistically significant (p > 0.05) when compared with the post-test data. The sensitivity test data were stable, and the results were reliable. We subgrouped the data from different types of exercise interventions and found that different types of exercise affected the experimental results.
UNASSIGNED: Exercise interventions have a positive effect on the treatment of patients with COPD, significantly improving functional capacity, aerobic capacity, and exercise tolerance, but they should be individualized and developed according to the patient\'s condition to achieve the best therapeutic effect.