■本研究采用文献计量和视觉分析来阐明自闭症谱系障碍(ASD)生物标志物的全球研究趋势,确定关键的研究重点,并讨论了不同生物标志物模式的潜在整合,以进行精确的ASD评估。
■使用WebofScienceCoreCollection数据库中的数据进行了全面的文献计量分析,直到2022年12月31日。可视化工具,包括R,VOSviewer,CiteSpace,和gcluto,被用来检查协作网络,共同引文模式,和国家之间的关键词关联,机构,作者,期刊,文件,和关键词。
■ASD生物标志物研究出现于2004年,到2022年12月31日积累了4348个文档的语料库。美国,拥有1574份出版物和213的H指数,成为最多产和最具影响力的国家。加州大学,戴维斯,以346份出版物和69的H指数做出了重大贡献,使其成为领先的机构。关于期刊,自闭症和发育障碍杂志,自闭症研究,在总共1140种学术期刊中,PLOSONE是ASD生物标志物相关文章的前三名出版商。共引和关键词分析揭示了遗传学的研究热点,成像,氧化应激,神经炎症,肠道菌群,和眼动追踪。新兴主题包括“DNA甲基化,\"\"眼动追踪,代谢组学,“和”静息状态功能磁共振成像。\"
■ASD生物标志物研究领域正在动态发展。未来的努力应该优先考虑个人分层,方法标准化,生物标志物模式的和谐整合,和纵向研究,以提高ASD诊断和治疗的准确性。
UNASSIGNED: This study employs bibliometric and visual analysis to elucidate global research trends in Autism Spectrum Disorder (ASD) biomarkers, identify critical research focal points, and discuss the potential integration of diverse biomarker modalities for precise ASD assessment.
UNASSIGNED: A comprehensive bibliometric analysis was conducted using data from the Web of Science Core Collection database until December 31, 2022. Visualization tools, including R, VOSviewer, CiteSpace, and gCLUTO, were utilized to examine collaborative networks, co-citation patterns, and keyword associations among countries, institutions, authors, journals, documents, and keywords.
UNASSIGNED: ASD biomarker research emerged in 2004, accumulating a corpus of 4348 documents by December 31, 2022. The United States, with 1574 publications and an H-index of 213, emerged as the most prolific and influential country. The University of California, Davis, contributed significantly with 346 publications and an H-index of 69, making it the leading institution. Concerning journals, the Journal of Autism and Developmental Disorders, Autism Research, and PLOS ONE were the top three publishers of ASD biomarker-related articles among a total of 1140 academic journals. Co-citation and keyword analyses revealed research hotspots in genetics, imaging, oxidative stress, neuroinflammation, gut microbiota, and eye tracking. Emerging topics included \"DNA methylation,\" \"eye tracking,\" \"metabolomics,\" and \"resting-state fMRI.\"
UNASSIGNED: The field of ASD biomarker research is dynamically evolving. Future endeavors should prioritize individual stratification, methodological standardization, the harmonious integration of biomarker modalities, and longitudinal studies to advance the precision of ASD diagnosis and treatment.