■二十二碳六烯酸(DHA)在婴儿大脑的生长和功能发育中起着至关重要的作用。然而,在随机对照试验中,额外补充DHA对婴儿神经发育的影响仍存在争议.在这篇系统综述和荟萃分析中,我们旨在研究产前和产后补充DHA对神经发育的影响。
■我们系统地搜索了MEDLINE,EMBASE,和Cochrane图书馆电子数据库使用预定义的策略,直到2024年2月8日。我们提取了与神经系统相关的相关研究特征和结果。两名独立审稿人对纳入的研究进行了批判性评估,以评估其有效性和偏倚风险。
■共有21项研究符合我们的纳入标准,一项研究在质量评估后被删除,荟萃分析包括9项随机对照试验.meta分析结果显示,DHA补充组与安慰剂组比较差异无统计学意义,根据智力发展指数[MDI;平均差异(MD),0.41;95%置信区间(CI),-0.91至1.73;p=0.55]。然而,DHA组的精神运动发育指数(PDI)明显高于安慰剂组(MD,1.47;95%CI,0.23至2.72;p=0.02)。基于人群的亚组分析显示,对于两种MDI的婴儿,DHA补充剂均优于安慰剂(语言评分转换;MD,2.05;95%CI,-0.16至4.26;p=0.07)和PDI(MD,1.94;95%CI,0.23至3.65;p=0.03)。其他亚组分析表明两组之间没有统计学差异。无法定量总结的其余评估进行了叙述性评估。
■根据BSID评估,婴儿补充DHA可能具有潜在的神经发育益处。由于荟萃分析包含的高质量文章很少,并且有一定的局限性,需要更多相关文章来解决婴儿单独补充DHA的需求,孕妇,和哺乳期的母亲。
■https://www.crd.约克。AC.uk/prospro/display_record.php?ID=CRD42022348100,标识符:CRD42022348100。
UNASSIGNED: Docosahexaenoic acid (
DHA) plays a crucial role in the growth and functional development of the infant brain. However, the impact of additional
DHA supplementation on neurodevelopment in infants remains controversial in randomized controlled trials. In this systematic review and meta-analysis, we aimed to investigate the effects of prenatal and postnatal
DHA supplementation on neurodevelopment.
UNASSIGNED: We systematically searched the MEDLINE, EMBASE, and Cochrane Library electronic databases using a predefined strategy until 8 February 2024. We extracted relevant study characteristics and outcomes related to the nervous system. Two independent reviewers critically evaluated the included studies to assess their validity and risk of bias.
UNASSIGNED: A total of 21 studies met our inclusion criteria, one study was removed after quality assessment, and the meta-analysis included 9 randomized controlled trials. The meta-analysis results indicated that there was no statistically significant difference between the
DHA supplementation group and the placebo group, as assessed by the Mental Development Index [MDI; mean difference (MD), 0.41; 95% confidence interval (CI), -0.91 to 1.73; p = 0.55]. However, the
DHA group had a significantly higher Psychomotor Development Index (PDI) than the placebo group (MD, 1.47; 95% CI, 0.23 to 2.72; p = 0.02). Subgroup analyses based on populations showed that DHA supplementation was superior to placebo for infants in both MDI (language score conversion; MD, 2.05; 95% CI, -0.16 to 4.26; p = 0.07) and PDI (MD, 1.94; 95% CI, 0.23 to 3.65; p = 0.03). Other subgroup analyses indicated no statistical differences between the two groups. The remaining assessments that could not be summarized quantitatively underwent a narrative evaluation.
UNASSIGNED: Based on the BSID assessments, DHA supplementation in infants may have potential neurodevelopmental benefits. Because the meta-analysis included few high-quality articles and had some limitations, more relevant articles are needed to address the need for separate DHA supplementation in infants, pregnant women, and lactating mothers.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022348100, identifier: CRD42022348100.