目的:我们进行了一项基于人群的队列研究,以调查儿童和青少年原发性腮腺恶性肿瘤(MPT)的临床特征和生存率。
方法:监测,流行病学,和最终结果(SEER)数据库用于识别2000年至2018年间诊断为MPT的所有儿科和青少年患者.根据一些参数,使用Kaplane-Meier估计产生存活曲线.使用对数秩检验比较存活曲线。使用多变量Cox比例风险模型检查了每种成分对总生存期(OS)的影响。
结果:有352名儿童和青少年MPT患者。诊断时,年龄从1.0到19岁,中位数为15年。粘液表皮样癌(MC)(46.5%)是最常见的组织学亚型,其次是腺泡细胞癌(ACC)(36.4%)和其他(17.1%),如腺样囊性癌和鳞状细胞癌。所有患者的总生存率为98.8%,95.6%,1年期为94.6%,3年和5年,分别。Cox比例风险回归结果显示,肿瘤分级,SEER阶段,放射治疗,和治疗方案是总生存期的显著独立预测因子.
结论:在儿科和青少年MPT中,肿瘤分级,SEER阶段,辅助辐射,发现治疗方案是生存的重要独立预测因子。需要更多的研究来验证辅助辐射的作用。
OBJECTIVE: We performed a population-based cohort study to investigate the clinical characteristics and survival rates of primary malignant parotid tumors (MPT) in children and adolescents.
METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify all pediatric and adolescent patients with MPT who were diagnosed between 2000 and 2018. Based on a number of parameters, survival curves were produced using Kaplane-Meier estimates. The log-rank test was used to compare survival curves. The influence of each component on overall survival (OS) was examined using a multivariate Cox proportional hazards model.
RESULTS: There were 352 identified pediatric and adolescent patients with MPT. At diagnosis, the age ranged from 1.0 to 19 years, with a median of 15 years. Mucoepidermoid carcinoma (MC) (46.5 %) was the most common histological subtype, followed by acinar cell carcinoma (ACC) (36.4 %) and others (17.1 %) such as adenoid cystic carcinoma and squamous cell carcinoma. All patients had overall survival rates of 98.8 %, 95.6 %, and 94.6 % at 1-year, 3-year and 5-year, respectively. The results of the Cox proportional hazard regression showed that tumor grade, SEER stage, radiotherapy, and treatment regimens were significant independent predictors of overall survival.
CONCLUSIONS: In pediatric and adolescent MPT, tumor grade, SEER stage, adjuvant radiation, and treatment regimens were found to be important independent predictors of survival. More research is required to validate the role of adjuvant radiation.