背景:原发性前列腺滑膜肉瘤是一种极其罕见的间叶性恶性软组织肿瘤,具有独特的形态学特征。滑膜肉瘤常发生于年轻人四肢的关节旁组织,但很少发生在前列腺。因为它非常罕见,临床上易误诊为良性前列腺增生或前列腺癌。尚未报道一例前列腺同步腺泡腺癌。在这篇文章中,我们报道了一例原发性前列腺滑膜肉瘤伴腺泡腺癌的独特病例。
方法:一名58岁男性患者在体检中发现前列腺肿块。前列腺超声检查显示前列腺体积增加5.2×3.3×3.3cm,混合回声块可以在前列腺的左侧看到,尺寸约为4.9×4.3厘米,左精囊压缩。
方法:前列腺滑膜肉瘤(双相型)合并前列腺腺泡腺癌(Gleason3+3)。
方法:患者接受前列腺癌根治术,其次是辅助化疗和放疗。
结果:经过2个月的随访,在写这篇文章的时候,患者接受辅助化疗和放疗的综合治疗计划,为期2个月,未发现复发或转移。
结论:原发性前列腺滑膜肉瘤(双相型)合并前列腺腺泡腺癌是一种非常独特且罕见的病例,有效的治疗指南尚不明确,给临床治疗带来新的挑战。充分利用病理和影像学检查,早期诊断和根治性手术结合多学科治疗似乎仍然是一种积极的方法。
BACKGROUND: Primary synovial sarcoma of the prostate is an extremely rare mesenchymal malignant soft tissue tumor with unique morphological features. Synovial sarcoma often occurs in the pararticular tissues of limbs in young people, but rarely occurs in prostate. Because it is very rare, it is easily misdiagnosed as benign prostatic hyperplasia or prostate cancer clinically. A
case of synchronous acinar adenocarcinoma of the prostate has not been reported. In this article, we report a unique
case of primary prostatic synovial sarcoma with acinar adenocarcinoma.
METHODS: A 58-year-old male patient was found to have a prostate mass during physical examination. Prostate ultrasound examination showed an increase in prostate volume of 5.2 × 3.3 × 3.3 cm, mixed echo mass can be seen on the left side of the prostate, with a size of approximately 4.9 × 4.3 cm, left seminal vesicle compressed.
METHODS: Prostatic synovial sarcoma (biphasic type) combined with prostatic acinar adenocarcinoma (Gleason 3 + 3).
METHODS: The patient received radical prostatectomy, followed by adjuvant chemotherapy and radiotherapy.
RESULTS: After 2 months of follow-up, at the time of writing this article, the patient received a comprehensive treatment plan of adjuvant chemotherapy and radiotherapy for 2 months, and no recurrence or metastasis was found.
CONCLUSIONS: Primary prostatic synovial sarcoma (biphasic type) combined with prostatic acinar adenocarcinoma is a very unique and rare
case, and effective treatment guidelines are not yet clear, posing new challenges to clinical treatment. Making full use of pathological and imaging examinations, early diagnosis and radical surgery combined with multidisciplinary treatment seem to be still a positive method.