背景:原发性气管腺泡细胞癌(ACC)是一种非常罕见的恶性肿瘤,在理解其临床行为和优化管理方面构成挑战。传统上,手术切除是主要的治疗方式,但是我们提出了一个令人信服的气管ACC用气管内介入治疗的案例,具有挑战性的传统方法。
方法:一名53岁女性出现呼吸急促,咳嗽,还有咯血.增强计算机断层扫描显示阻塞性气管病变,导致她转介进一步评估。
方法:微观评估,免疫组织化学,和临床评估证实原发性气管ACC,一种极其罕见的疾病,临床见解有限。
方法:我们利用硬支气管镜进行气管内介入,成功切除肿瘤,恢复气管通畅。术后,患者未接受放疗或化疗.
结果:患者完全康复,24个月的随访检查表明没有复发或转移性疾病。切除部位仅保留了最小的疤痕组织。
结论:该病例证明了气管内干预作为原发性气管ACC的治疗方法的潜力,减少侵入和保持气管功能。合作研究工作和广泛的病例报告对于提高我们对这种罕见恶性肿瘤的理解和优化治疗策略以改善患者预后至关重要。
BACKGROUND: Primary tracheal acinic cell carcinoma (ACC) is an exceptionally rare malignancy, posing challenges in understanding its clinical behavior and optimal management. Surgical resection has traditionally been the primary treatment modality, but we present a compelling case of tracheal ACC managed with endotracheal intervention, challenging conventional approaches.
METHODS: A 53-year-old woman presented with shortness of breath, cough, and hemoptysis. Enhanced computed tomography revealed an obstructive tracheal lesion, leading to her referral for further assessment.
METHODS: Microscopic evaluation, immunohistochemistry, and clinical assessments confirmed primary tracheal ACC, an exceedingly rare condition with limited clinical insights.
METHODS: We utilized rigid bronchoscopy to perform endotracheal intervention, successfully resecting the tumor and restoring tracheal patency. Postoperatively, the patient received no radiotherapy or chemotherapy.
RESULTS: The patient achieved complete recovery, with 24-month follow-up examinations indicating no recurrence or metastatic disease. Only minimal scar tissue remained at the resection site.
CONCLUSIONS: This case demonstrates the potential of endotracheal intervention as a curative approach for primary tracheal ACC, minimizing invasiveness and preserving tracheal function. Collaborative research efforts and extensive case reporting are crucial for advancing our understanding of this rare malignancy and optimizing treatment strategies for improved patient outcomes.