大脑-肠道轴将肠道微生物群(GM)生态失调与自闭症谱系障碍(ASD)的发展或恶化紧密相连。然而,ASD中准确的GM成分和益生菌的有效性尚不清楚.为了解决这个问题,我们对PubMed,PsycINFO,WebofScience,Scopus,和MEDLINE,涉及1,256名ASD儿童和1042名神经典型儿童,到2024年2月。使用Revman5.3,我们分析了8个门和64个属的相对丰度。虽然患有ASD的个体在包括门方面没有表现出显著差异,它们表现出水平升高的副杆菌属,厌氧症,粪杆菌,梭菌属,Dorea,相颈杆菌,衣原体,副杆菌属,和Collinsella以及减少的Barnesiella百分比,Odoribacter,Paraprevotella,Blautia,Turicibacter,落叶螺旋体,假单胞菌,Parasutterilla,嗜血杆菌,和双歧杆菌.值得注意的是,粪杆菌的差异,梭菌属,Dorea,相颈杆菌,副杆菌属,Odoribacter,甚至在系统排除个体研究后,双歧杆菌仍然存在。因此,ASD患者的GM表现出不平衡,有可能增加或减少有益和有害的细菌。因此,针对ASD细节的个性化益生菌干预措施势在必行,而不是一刀切的方法。
The brain-gut axis intricately links gut microbiota (GM) dysbiosis to the development or worsening of autism spectrum disorder (ASD). However, the precise GM composition in ASD and the effectiveness of probiotics are unclear. To address this, we performed a thorough meta-analysis of 28 studies spanning PubMed, PsycINFO, Web of Science, Scopus, and MEDLINE, involving 1,256 children with ASD and 1042 neurotypical children, up to February 2024. Using Revman 5.3, we analyzed the relative abundance of 8 phyla and 64 genera. While individuals with ASD did not exhibit significant differences in included phyla, they exhibited elevated levels of Parabacteroides, Anaerostipes, Faecalibacterium, Clostridium, Dorea, Phascolarctobacterium, Lachnoclostridium, Catenibacterium, and Collinsella along with reduced percentages of Barnesiella, Odoribacter, Paraprevotella, Blautia, Turicibacter, Lachnospira, Pseudomonas, Parasutterella, Haemophilus, and Bifidobacterium. Notably, discrepancies in Faecalibacterium, Clostridium, Dorea, Phascolarctobacterium, Catenibacterium, Odoribacter, and Bifidobacterium persisted even upon systematic exclusion of individual studies. Consequently, the GM of individuals with ASD demonstrates an imbalance, with potential increases or decreases in both beneficial and harmful bacteria. Therefore, personalized probiotic interventions tailored to ASD specifics are imperative, rather than a one-size-fits-all approach.